Tacere Therapeutics Enters Collaboration and License Agreement With Pfizer To Develop and Commercialize RNAi Hepati...(for TT-033. In addition Tacere will be e...),Health

Date:1/7/2008

for TT-033. In addition, Tacere will be eligible to receive milestone payments through successful achievement of development, approval, and commercialization milestones resulting in total potential payments to Tacere of over $145 million. Upon commercialization of TT-033 Tacere would be entitled to receive royalties on net sales by Pfizer.

About TT-033

TT-033 is a novel therapeutic product containing three separate RNAi elements targeted against the Hepatitis C virus itself and entrapped in an AAV protein coat. AAV delivery methods have demonstrated clinical safety, and preclinical studies with TT-033 have shown the ability to penetrate hepatocytes (the site of HCV replication) at high levels following a single intravenous administration. In preclinical animal studies, this "cocktail in one drug" monotherapy targeted and cleaved the Hepatitis C virus itself at three different sites simultaneously without toxicity.

About Tacere Therapeutics, Inc.

Tacere is an innovative biotechnology company focused on developing therapeutics to treat serious infectious diseases using its proprietary knowledge in the development of RNAi therapeutics. Tacere is located in San Jose, California, USA and obtained its founding capital from Hokkaido Venture Capital of Sapporo, Japan. Its lead therapeutic compound is TT-033, an RNAi drug for the treatment of Hepatitis C. For additional information, please visit http://www.tacerebio.com.

CONTACTS:

TACERE THERAPEUTICS, INC.

Mike Catelani

Chairman, President & CFO

+1 408 839-1818

info@tacerebio.com

MEDIA CONTACT:

Gregory Tiberend

Richard Lewis Communications, Inc.

+1 212 827-0020 or 917 406-1880

gtiberend@rlcinc.com

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SOURCE Tacere Therapeutics, Inc. Copyright©2008 PR Newswire. All rights reserved

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