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TYRX Presents Early Clinical Results from AIGISRX(TM) Antibacterial Envelope Retrospective Registry
Date:5/14/2009

Corticosteroid use 30 7.6 22 8.7 Temporary pacing wire 8 2 3 1.18 > 2 leads in place 163 41.5 105 41.3 Device Revsion 278 70.7 187 73.6 Early reintervention 9 2.3 9 3.5

Dr. Dan Lerner continued, "Of the 3 generator pocket infections reported to date, 2 occurred in patients who had prior explants for infection within the past 6 months. Importantly, these early data indicate AIGIS does not interfere with CRMD implant success. The AIGIS Retrospective Registry continues with the expectation that, with the enrollment of 3 additional clinical sites, TYRX will collect data on over 500 AIGIS patients, representing more than 15% of the 3,000 AIGIS implanted to-date. The company plans to continue the AIGIS Retrospective Registry follow-up period will provide clinicians greater insight into the clinical utility of AIGIS."

"We are delighted these data indicate clinicians are using AIGIS in the full spectrum of CRMD implant procedures. In particular, it is gratifying to see that AIGIS is being used in patients who are at very high risk for CRMD infection," added Bill Edelman, CEO of TYRX, Inc. "In addition to the AIGIS Retrospective Registry, we have begun the process of recruiting approximately 20 clinical sites for the AIGIS Prospective Registry, which will follow AIGIS patients for 12 months and compare the incidence of infection to published historical and case-matched controls of cardiac rhythm management device (CRMD) recipients. TYRX is committed to better understanding how the AIGIS envelope can help the greatest number of patients."

Additional information regarding TYRX, Inc.'s Retrospective and Prospective Registries, and associated clinical results, can be found at

SOURCE TYRX, Inc.
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