TYKERB(R) (Lapatinib) to be Investigated in Landmark Early Breast Ca... (g disease andpneumonitis. Discontinue TY...)

TYKERB(R) (Lapatinib) to be Investigated in Landmark Early Breast Cancer Trial

Date:5/12/2008

g disease and pneumonitis. Discontinue TYKERB if patients experience severe pulmonary symptoms.

TYKERB prolongs the QT interval in some patients. Consider ECG and electrolyte monitoring.

Fetal harm can occur when administered to a pregnant woman. Women should be advised not to become pregnant when taking TYKERB.

The most common adverse events (>20 percent) during treatment with TYKERB plus capecitabine were diarrhea, vomiting, nausea, fatigue, palmar-plantar erythrodysethesia, and rash.

*Please see full prescribing information.

Cautionary statement regarding forward-looking statements

Under the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Factors that may affect GSK's operations are described under 'Risk Factors' in the 'Business Review' in the company's Annual Report on Form 20-F for 2007.

Notes to editors:

TYKERB(R) is a registered trademark of the GlaxoSmithKline group of companies.

TYVERB(R) is a registered trademark of the GlaxoSmithKline group of companies in Europe and is the proposed trade name in certain markets, pending regulatory approval.

US Media enquiries: Sarah Alspach +1 919 483 2839

Mary Anne Rhyne +1 919 483 2839

UK Media enquiries: Philip Thomson +44 20 8047 5502

Gwenan White +44 20 8047 5502

Alice Hunt +44 20 8047 5502

European Analyst/Investor

enquiries: David Mawdsley +44 20 8047 5564

Sally Ferguson +4
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