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Worldwide, breast cancer is by far the most frequent cancer affecting women, with over one million new cases each year; breast cancer is also the leading cause of female cancer-related deaths.(2) Approximately 20 to 85 percent of patients (depending on initial stage, tumor biology, and treatment strategy) diagnosed with early breast cancer will develop recurrent and/or metastatic disease.(3)

About BIG

The Breast International Group (BIG), based in Brussels, Belgium, is an international non-profit organization for academic breast cancer research groups from around the world. By encouraging interaction and cooperation between its members and related cancer networks, and by collaborating with, but working independently from, the pharmaceutical industry, BIG's mission is to facilitate the conduct of large and difficult breast cancer clinical trials and to reduce the wasteful duplication of efforts. Created by leading European opinion leaders in 1996, BIG now constitutes a network of 41 groups in Europe, Canada, Latin America, Australia/New Zealand and Asia. These research entities, which coordinate the BIG trials, are in turn tied to approximately 3,000 specialized hospitals and research centers round the world. In 2004, BIG founded a complementary network for translational research, which involves 40 partners in 22 countries and is partially supported by the European Commission; to optimize research collaboration globally, BIG has also forged strong ties with North American collaborative groups. Through these efforts BIG hopes ultimately to advance knowledge about breast cancer and better serve the women whose lives are affected by this disease.

About SOLTI

SOLTI is a non-for-profit organization under Spanish law, made up of a network of around 30 medical oncology departmen
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