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TWi Biotechnology Receives Patent Allowance for Its Lead Drug Candidate AC-201 in the United States
Date:9/10/2013

TAIPEI, Sept. 10, 2013 /PRNewswire/ -- TWi Biotechnology, Inc., today announced that it has received an official notification of patent allowance for AC-201, TWi Biotechnology's lead drug candidate, from the United States Patent & Trademark Office. The granted patent, US patent number 8,536,152, covers AC-201's use as a combination therapy with other existing blood glucose lowering therapy agents to treat Type II diabetes. The patent is part of TWi Biotechnology's broad intellectual property portfolio for AC-201.

"We are very pleased with the issuance of this patent in United States for AC-201. This is the third patent TWi Biotechnology has received this year for our diabetes franchise," said Dr. Calvin C. Chen, President of TWi Biotechnology. "This new issuance provides TWi Biotechnology the intellectual property protection needed for AC-201 to address an unmet medical need for an effective treatment for chronic type II diabetes. Currently, the first line treatment for blood glucose therapy is metformin or sulfonylurea monotherapy. However, monotherapy with metformin or sulfonylurea still has limited benefit. Many patients fail to achieve the treatment goal after going through an extended treatment period. Our AC-201, in combination with existing blood glucose lowering therapy agents including metformin, has demonstrated its efficacy of reducing HbA1c levels in type 2 diabetic patients in two phase II clinical trials. TWi Biotechnology had presented the results of a 259-patient multinational phase IIb study in the American Diabetes Association 73rd Scientific Sections in Chicago, USA."

About AC-201

AC-201 is a first-in-class, orally available small molecule which has shown the ability to inhibit the production and activity of the cytokine IL-1Beta and to down-regulate the IL-1Beta receptors. Inhi
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SOURCE TWi Pharmaceuticals, Inc.
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