Navigation Links
TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men
Date:8/3/2009

PHOENIX, Aug. 3 /PRNewswire-USNewswire/ -- The Phoenix-based Kronos Longevity Research Institute (KLRI) has published two new publications on hormone therapies and their effects on reducing the risks of cardiovascular disease in older adults.

Cardiovascular disease caused by atherosclerosis, or the build-up of plaques along the arterial wall, is the greatest single killer of American women--40% of total deaths--and the rate of mortality is nearly as high for men. Atherosclerosis can lead to the blockage of arteries that commonly support the heart, brain, kidneys and extremities, and cause blood clots, heart attacks and stroke.

Published in the American Society for Reproductive Medicine's Menopausal Medicine, KLRI publications findings were twofold that there are certain benefits to menopausal hormone therapy (HT) in newly postmenopausal women, but that there are risks and a potential loss of benefit to estrogen therapy in women who have been postmenopausal for several years and may have pre-existing atherosclerosis.

"This research continues to underscore the theory that estrogen may be cardio-protective if administered close to menopause," said Dr. S. Mitchell Harman, M.D., Ph.D., KLRI's Director and President.

The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial compared conjugated equine estrogen (CEE) with three different CEE-progestin combinations and placebo in 875 healthy, postmenopausal women, aged 45 to 64. KLRI has found that other trial results used by the FDA, American Heart Association and other groups began menopausal HT use much later than in usual clinical practice--beginning trials on women of a median age of 63, as opposed to 51 (the average age of menopause in the United States). Younger women saw benefits from menopausal HT; older women saw the opposite.

KLRI research project, The Kronos Early Estrogen Prevention Study (KEEPS), will more fully address the issue of the benefits of menopausal HT in women close to the menopausal transition. Results from this study are not expected for several more years.

Another KLRI study, appearing in the Journal of Clinical Endocrinology and Metabolism and led by Marc Blackman of the Washington DC VA Medical Center, tests the effects of growth hormone (GH) therapy, both combined with sex steroids and alone, in healthy, ambulatory men and women over 65 years of age for a period of six months. The study found that GH caused insulin resistance (the body's inability to respond to and use the insulin it produces) to increase, yet it had a beneficial effect on lipids (molecules in the blood that include cholesterol and triglycerides).

"It's extremely unusual to analyze the effect of both growth hormone and sex steroids," said Harman.

This research is particularly interesting because the effects of GH therapy have not been studied extensively. The body naturally secretes growth hormones to fuel growth through childhood and maintain tissues and organs. Their use as an anti-aging therapy stems from the natural decrease of growth hormones secreted by the body as we reach middle age--replacing them with artificial GH, in theory, would slow the aging process. However, there is little evidence to suggest that it is effective.

Very few studies have tested the combined effects of GH and sex-steroids on glucose tolerance, elevated cholesterol and insulin sensitivity--changes in older adults that occur as a result of aging and that contribute to increased risk for cardiovascular disease. GH has been found to decrease total body and regional fat mass in older men, while sex-steroids have been reported to have positive effects on lipid (fat) concentrations in the body.

About Kronos Longevity Research Institute

Kronos Longevity Research Institute (KLRI) is a not-for-profit, 501(c)(3) organization that conducts state-of-the-art clinical translational research on the prevention of age-related diseases and the extension of healthier human life. KLRI tests new strategies to detect and prevent chronic diseases associated with aging and investigates the effects of innovative interventions to slow the aging process and improve health outcomes for older persons. In addition, KLRI helps the medical and lay communities understand important aging issues. KLRI research findings support a healthier quality of life and a robust lifestyle in our senior years. For more information, visit www.kronosinstitute.org.


'/>"/>
SOURCE Kronos Longevity Research Institute
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
2. Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP
3. Emisphere Technologies Announces the Launch of a Human Clinical Trial For Oral Parathyroid Hormone (PTH)
4. Poniard Announces Positive First-Line Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in Patients with Metastatic Hormone Refractory Prostate Cancer
5. Data Presented at AACR Annual Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Tumor Growth By Up to 95% and Halts Metastasis in a Model of Hormone-Refractory Prostate Cancer
6. Nastech Reacquires Teriparatide (Parathyroid Hormone; PTH1-34) Nasal Spray from Procter & Gamble
7. Medivations MDV3100 Demonstrates Substantial PSA Reductions in First Patient Groups Treated in Phase 1-2 Hormone Refractory Prostate Cancer Trial
8. Obesity-Related Hormone is Higher in Children with Down Syndrome
9. Study Results Show That Minimally Invasive Therapy is Successful for Over Two-Thirds of Stroke Patients Treated Outside the Standard Eight-Hour Window
10. Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy
11. First Skin Cancer Patients Treated With Electronic Brachytherapy (eBx) At University of Wisconsin Riverview Cancer Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... SAN DIEGO , Dec. 7, 2016   ... today announced that it has completed enrollment in the ... IP receptor agonist targeting the prostacyclin pathway for the ... approximately 60 patients at sites globally. "This ... and is evidence of our strategic focus on our ...
(Date:12/7/2016)... Dec. 7, 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) has ... Homecare Federation, At-Home IV Infusion Professional, BioRx, MedPro Rx, and XAS ... services, visit diplomat.is/specialty-infusion .  ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ... "As we continue to build on the ...
(Date:12/7/2016)... Kan. , Dec. 7, 2016   Rx Savings ... West Virginia and its Public Employees Insurance Agency ... members access to their innovative healthcare software, ultimately saving money ... with PEIA and provide its members with access to our ... or a more effective, affordable therapy can be found," says ...
Breaking Medicine Technology:
(Date:12/7/2016)... ... 2016 , ... Levels of a protein in the blood associated with heart ... in the journal Radiology. , Heart disease and brain disease exact a major burden ... aging population. Damage to both organs often occurs at a subclinical stage, or before ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... ... high performance connectors, is now promoting to the US market its advanced highly ... ODU LAMTAC® and ODU TURNTAC®. These advanced technologies are ideal for a ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... planning services to families and business owners in the greater Dallas metropolitan area, ... the Dallas Fallen Officer Foundation. , Established in 2009 by active police professionals ...
(Date:12/7/2016)... ... 07, 2016 , ... A. Kevin Spann Insurance, a New York-based firm offering ... is launching a charity drive to raise funds that will benefit the Marine Corps ... marines and Navy FMF Corpsmen. Working closely with the MCL, the A. Kevin Spann ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... that its fully redesigned website, which launched October 17, 2016, features comprehensive information ... design and easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology ...
Breaking Medicine News(10 mins):