Navigation Links
TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men

PHOENIX, Aug. 3 /PRNewswire-USNewswire/ -- The Phoenix-based Kronos Longevity Research Institute (KLRI) has published two new publications on hormone therapies and their effects on reducing the risks of cardiovascular disease in older adults.

Cardiovascular disease caused by atherosclerosis, or the build-up of plaques along the arterial wall, is the greatest single killer of American women--40% of total deaths--and the rate of mortality is nearly as high for men. Atherosclerosis can lead to the blockage of arteries that commonly support the heart, brain, kidneys and extremities, and cause blood clots, heart attacks and stroke.

Published in the American Society for Reproductive Medicine's Menopausal Medicine, KLRI publications findings were twofold that there are certain benefits to menopausal hormone therapy (HT) in newly postmenopausal women, but that there are risks and a potential loss of benefit to estrogen therapy in women who have been postmenopausal for several years and may have pre-existing atherosclerosis.

"This research continues to underscore the theory that estrogen may be cardio-protective if administered close to menopause," said Dr. S. Mitchell Harman, M.D., Ph.D., KLRI's Director and President.

The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial compared conjugated equine estrogen (CEE) with three different CEE-progestin combinations and placebo in 875 healthy, postmenopausal women, aged 45 to 64. KLRI has found that other trial results used by the FDA, American Heart Association and other groups began menopausal HT use much later than in usual clinical practice--beginning trials on women of a median age of 63, as opposed to 51 (the average age of menopause in the United States). Younger women saw benefits from menopausal HT; older women saw the opposite.

KLRI research project, The Kronos Early Estrogen Prevention Study (KEEPS), will more fully address the issue of the benefits of menopausal HT in women close to the menopausal transition. Results from this study are not expected for several more years.

Another KLRI study, appearing in the Journal of Clinical Endocrinology and Metabolism and led by Marc Blackman of the Washington DC VA Medical Center, tests the effects of growth hormone (GH) therapy, both combined with sex steroids and alone, in healthy, ambulatory men and women over 65 years of age for a period of six months. The study found that GH caused insulin resistance (the body's inability to respond to and use the insulin it produces) to increase, yet it had a beneficial effect on lipids (molecules in the blood that include cholesterol and triglycerides).

"It's extremely unusual to analyze the effect of both growth hormone and sex steroids," said Harman.

This research is particularly interesting because the effects of GH therapy have not been studied extensively. The body naturally secretes growth hormones to fuel growth through childhood and maintain tissues and organs. Their use as an anti-aging therapy stems from the natural decrease of growth hormones secreted by the body as we reach middle age--replacing them with artificial GH, in theory, would slow the aging process. However, there is little evidence to suggest that it is effective.

Very few studies have tested the combined effects of GH and sex-steroids on glucose tolerance, elevated cholesterol and insulin sensitivity--changes in older adults that occur as a result of aging and that contribute to increased risk for cardiovascular disease. GH has been found to decrease total body and regional fat mass in older men, while sex-steroids have been reported to have positive effects on lipid (fat) concentrations in the body.

About Kronos Longevity Research Institute

Kronos Longevity Research Institute (KLRI) is a not-for-profit, 501(c)(3) organization that conducts state-of-the-art clinical translational research on the prevention of age-related diseases and the extension of healthier human life. KLRI tests new strategies to detect and prevent chronic diseases associated with aging and investigates the effects of innovative interventions to slow the aging process and improve health outcomes for older persons. In addition, KLRI helps the medical and lay communities understand important aging issues. KLRI research findings support a healthier quality of life and a robust lifestyle in our senior years. For more information, visit

SOURCE Kronos Longevity Research Institute
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
2. Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP
3. Emisphere Technologies Announces the Launch of a Human Clinical Trial For Oral Parathyroid Hormone (PTH)
4. Poniard Announces Positive First-Line Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in Patients with Metastatic Hormone Refractory Prostate Cancer
5. Data Presented at AACR Annual Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Tumor Growth By Up to 95% and Halts Metastasis in a Model of Hormone-Refractory Prostate Cancer
6. Nastech Reacquires Teriparatide (Parathyroid Hormone; PTH1-34) Nasal Spray from Procter & Gamble
7. Medivations MDV3100 Demonstrates Substantial PSA Reductions in First Patient Groups Treated in Phase 1-2 Hormone Refractory Prostate Cancer Trial
8. Obesity-Related Hormone is Higher in Children with Down Syndrome
9. Study Results Show That Minimally Invasive Therapy is Successful for Over Two-Thirds of Stroke Patients Treated Outside the Standard Eight-Hour Window
10. Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy
11. First Skin Cancer Patients Treated With Electronic Brachytherapy (eBx) At University of Wisconsin Riverview Cancer Center
Post Your Comments:
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
Breaking Medicine Technology:
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
Breaking Medicine News(10 mins):