Navigation Links
TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet
Date:8/31/2008

Landmark ARB trial investigated Micardis(R) (telmisartan) against placebo in reducing the composite endpoint of cardiovascular death, myocardial infarction, stroke and hospitalization for congestive heart failure in ACE inhibitor intolerant high-risk patients receiving current standard of care

RIDGEFIELD, Conn., Aug. 31 /PRNewswire/ -- The primary results of the TRANSCEND(TM)* trial demonstrated that treatment with MICARDIS(R) (telmisartan) 80mg in patients receiving current standard of care resulted in an 8% reduction in the composite endpoint of cardiovascular death, myocardial infarction, stroke and hospitalization for congestive heart failure. This reduction was not statistically significant (p=0.216; HR 0.92) compared to patients receiving placebo in addition to current standard of care.(1) Results of the main secondary endpoint of TRANSCEND as pre-specified in the statistical plan demonstrated that telmisartan significantly reduced the risk of cardiovascular death, myocardial infarction and stroke in high-risk cardiovascular patients by 13% compared with those patients already receiving current standard of care (p=0.048).(1) This risk reduction was achieved despite a high proportion of patients receiving proven therapies such as statins, anti-platelet agents or beta blockers. The main secondary endpoint of TRANSCEND mirrors the primary endpoint of the landmark HOPE trial.(2) A post-hoc analysis to adjust for multiplicity and overlap with primary endpoint showed a p-value of 0.068.(1) The results were presented today at the annual meeting of the European Society of Cardiology in Munich, Germany and published online in The Lancet.

In high-risk patients who cannot tolerate an angiotensin-converting enzyme (ACE) inhibitor, the TRANSCEND trial was designed to investigate potential cardiovascular risk reduction benefits using the second-generation angiotensin II receptor blocker (ARB) telmisartan. Telmisartan was compared to placebo on top of
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
2. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
3. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
6. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... Jan. 15, 2014 As health officials across the Midwest ... Meijer pharmacies in Michigan will offer ... patients, enabling Meijer pharmacists to administer tests and, in some ... a physician participating in the study. The ...
(Date:1/15/2014)... Corporation (the "Company") (NASDAQ: CLSN ) today ... to purchase an aggregate of approximately $15 million of ... offering, led by a dedicated health care fund. ... these investors pursuant to which the Company agreed to ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... 2011 Omeros Corporation (NASDAQ: OMER ) ... in the Company,s Phase 3 clinical program evaluating OMS302 ... proprietary PharmacoSurgery™ products, is added to standard irrigation solution ... maintain intraoperative mydriasis (pupil dilation) and reduce postoperative pain ...
... YORK, Oct. 11, 2011 Reportlinker.com announces ... available in its catalogue: ... 2016 http://www.reportlinker.com/p0336530/Asia-Pacific-Orthopedic-Devices-Market-Outlook-to-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic ... Outlook to 2016 Summary ...
Cached Medicine Technology:Omeros Announces First Patients Treated in Phase 3 Clinical Program Evaluating OMS302 2Omeros Announces First Patients Treated in Phase 3 Clinical Program Evaluating OMS302 3Asia-Pacific Orthopedic Devices Market Outlook to 2016 2Asia-Pacific Orthopedic Devices Market Outlook to 2016 3Asia-Pacific Orthopedic Devices Market Outlook to 2016 4Asia-Pacific Orthopedic Devices Market Outlook to 2016 5Asia-Pacific Orthopedic Devices Market Outlook to 2016 6Asia-Pacific Orthopedic Devices Market Outlook to 2016 7Asia-Pacific Orthopedic Devices Market Outlook to 2016 8Asia-Pacific Orthopedic Devices Market Outlook to 2016 9Asia-Pacific Orthopedic Devices Market Outlook to 2016 10Asia-Pacific Orthopedic Devices Market Outlook to 2016 11Asia-Pacific Orthopedic Devices Market Outlook to 2016 12Asia-Pacific Orthopedic Devices Market Outlook to 2016 13Asia-Pacific Orthopedic Devices Market Outlook to 2016 14Asia-Pacific Orthopedic Devices Market Outlook to 2016 15Asia-Pacific Orthopedic Devices Market Outlook to 2016 16Asia-Pacific Orthopedic Devices Market Outlook to 2016 17Asia-Pacific Orthopedic Devices Market Outlook to 2016 18Asia-Pacific Orthopedic Devices Market Outlook to 2016 19
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier ... of 2014 Quinceanera dresses . The company’s new ... look fashionable without paying a large amount of money. ... 57% off. , The company’s online shop has become ... special occasion outfits. In addition to exquisite Quinceanera dresses, ...
(Date:7/11/2014)... The American Association of Poison Control Centers ... commending Senator Bill Nelson (D-FL) for his introduction of ... July 10, 2014. Along with fellow Senate co-sponsors, this ... to enact rules requiring safer, child-resistant packaging for any ... co-sponsors of the bill include: Sen. Richard Blumenthal (D-CT), ...
(Date:7/11/2014)... Down reports that tickets to the Argentina vs. Germany ... between Brazil and Netherlands are in high demand. ... 12th at Estadio Nacional de Brasilia Mane Garrincha Brasila, Federal ... July 13th at Estadio Jornalista Mario Filho - Estadio do ... Cup are guaranteed to be authentic and are covered by ...
(Date:7/11/2014)... 11, 2014 Butler Mobility has recently updated ... Platform Lifts . Previously the two standard colors were ... beautiful earth tone colors as standard colors at no additional ... the home but will enhance the beauty of the stairway. ... home color scheme or individual décor. , The new selection ...
(Date:7/11/2014)... (HealthDay News) -- People with the lowest incomes may have ... disease (PAD), a new study suggests. People with PAD ... limbs, most often the legs. The condition causes leg pain ... throughout the body. People with PAD have a higher risk ... nearly 6,800 people with PAD who took part in the ...
Breaking Medicine News(10 mins):Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2Health News:Poor More Prone to Leg Circulation Trouble 2
... HealthDay Reporter , THURSDAY, Feb. 24 (HealthDay News) -- A ... of the organ a day after birth, scientists report. ... that ways can be found to help the human heart ... heart for regeneration, but they,re somehow permanently switched off," said ...
... New findings by a University of Maryland-led team of ... for a human anti-malarial antibody or a scorpion ... environmentally friendly tool for combating malaria, at a time ... is declining. In a study published in the ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, Feb. ... decades ago, they are still pervasive in the United States ... a new study suggests. In fact, PCBs may account ... after IVF, the researchers said. "These findings may help ...
... redesign of the nation,s donor-liver distribution network developed by ... more people each year receiving the transplants they need. ... Management Science that donor livers currently are doled ... regard for geography and demographics, an arrangement that prevents ...
... State University has secured a $7.9 million award ... through increasing the African nation,s agricultural productivity, creating ... grant, funded by the U.S. Agency for International ... of Florida. The initiative employs trilateral cooperation, which ...
... California A new research study from Loma Linda ... may help contribute to heart health and disease prevention; ... of The Journal of Nutrition . ... as tocopherols, plus numerous phenolic substances, many of them ...
Cached Medicine News:Health News:Scientists Say Newborn Mice Can Regrow Damaged Hearts 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 3Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 4Health News:PCBs Might Be Linked to Failed IVF Attempts 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 3Health News:$7.9 million grant to improve food security, nutrition in Mozambique 2Health News:Antioxidants in pecans may contribute to heart health and disease prevention 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: