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TOZAL(R) Nutritional Supplement Improves Vision in Common Form of Macular Degeneration
Date:9/10/2008

eye tests. Participants were instructed to take TOZAL three times a day and to maintain a log, which was checked by researchers on each visit. The primary objective of the study was to measure change in visual acuity, while a secondary objective was to find improved macular function as measured by these tests.

"We saw significant improvements in visual acuity, but did not see demonstrated improvements in function," said Dr. Cangemi. "This is likely due to the short duration of the study."

The study's Institutional Review Board determined that all patients must receive the standard of care, so no true placebo arm was permitted. Instead, Dr. Cangemi used a widely accepted placebo protocol and constructed comparisons with placebo data from the "MIRA-1" study, which followed the same inclusion and exclusion criteria as TOZAL. All patients in the MIRA study -- including those in the placebo arm -- received AREDS supplements.

Patients in the TOZAL study were initially divided into two groups: those receiving TOZAL plus electrical microcurrent stimulation (MCS) and those receiving TOZAL and sham MCS. MCS was abandoned early in the study. Reported results are based on the arm of the study in which 37 patients received TOZAL and sham MCS.

TOZAL was developed by Edward L. Paul, O.D., Ph.D., an optometrist and nutritionist who is an authority on nutrition and vision loss. Dr. Paul has licensed the TOZAL formulation to AmeriSciences, a leading developer of science-based nutritional supplements that is based in Houston. He serves on the AmeriSciences Scientific Advisory Board.

Dr. Cangemi received funding for the study and manuscript preparation from Atlantic Medical, Inc., a company that holds patent rights to TOZAL.


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SOURCE Atlantic Medical, Inc.
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