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TOPICA Names Mark W. Davis Vice President of Clinical Development
Date:2/18/2010

to joining TOPICA, he served in project leadership roles and as head of Clinical Operations at Onyx Pharmaceuticals developing oncology products.  Prior to Onyx, he was Senior Director of Clinical Operations at Connetics Corporation, where he successfully led clinical programs for three dermatologic product approvals in the United States.  Mr. Davis also spent more than 12 years in clinical development at Amgen.  Mr. Davis earned his M.S. in biomedical engineering from the University of Utah and his B.S. in biomedical engineering from the University of California, San Diego.

About Luliconazole

Luliconazole is one of the most potent and broad-spectrum topical antifungal agents. TOPICA is developing luliconazole for onychomycosis, which affects approximately 35 million people in the U.S. Currently approved therapies for onychomycosis are either ineffective or are complicated by the potential of liver toxicity and require hepatic monitoring.  In numerous rigorous preclinical models of onychomycosis, luliconazole has demonstrated rapid penetration and therapeutically effectively levels in the nail bed.  This preclinical profile suggests luliconazole has the potential to be the first highly effective and safe topical therapy for onychomycosis.  The potential annual U.S. market for onychomycosis treatment is estimated at approximately $3 billion.

TOPICA is also developing luliconazole for the treatment of tinea pedis, the most common fungal infection of the skin, affecting about one in every 10 people.  In the U.S. more than 22 million prescriptions are written annually for tinea infections.  Currently approved products for the topical treatment of tinea pedis are only modestly effective, have a high reoccurrence rate and require a month of therapy.  In 2009, TOPI
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SOURCE TOPICA Pharmaceuticals
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