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T1D Exchange Awarded $2.8M Grant by JDRF to Study Metformin and Type 1 Diabetes
Date:11/1/2013

BOSTON, Nov. 1, 2013 /PRNewswire/ -- T1D Exchange, the first program of the new nonprofit organization Unitio, has received a $2.8 million research grant from JDRF to study the use of metformin—a drug used as first-line treatment for type 2 diabetes—in combination with standard insulin therapy in overweight adolescents with type 1 diabetes.

The study will include a minimum of 136 adolescents with type 1 diabetes who are overweight and have failed to achieve optimal blood sugar control with insulin alone. Study participants will continue insulin therapy and will be randomly assigned to receive either metformin or a placebo. Blood sugar control and side effects of the treatment will be assessed over a 6-month period.  In a concurrent study involving a subset of the participants, testing will be done to assess whether metformin improves insulin sensitivity.

"We are very excited to partner with JDRF in this important study to better understand the benefits and risks of the use of metformin in overweight adolescents with type 1 diabetes and evidence of insulin resistance," said Dana Ball, executive director and co-founder of T1D Exchange. "JDRF and T1D Exchange share the goal of improving the lives of people with type 1 diabetes, and we look forward to future collaborative opportunities."

The efficacy of metformin, a drug that is used to control the amount of glucose in the blood of those with type 2 diabetes, is largely unknown for those with type 1 diabetes.

"For more than 90 years, insulin has been the primary therapy for people with type 1 diabetes; but the fact remains that despite vigilant management, glycemic control is a huge challenge for many with the disease," said Sanjoy Dutta, Ph.D., senior director of treat therapies at JDRF. "Previous studies have built a body of evidence showing the potential of certain adjunct therapi
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SOURCE T1D Exchange
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