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Systematic Review Finds Intranasal Midazolam Comparable To Intravenous Or Rectal Administration Of Diazepam For Treatment Of Acute Seizure Emergencies In Pediatric Patients
Date:11/1/2013

MAPLE GROVE, Minn., Nov. 1, 2013 /PRNewswire/ -- A new systematic review found that when compared with intravenous or rectally administered diazepam, intranasal midazolam was equally effective and demonstrated comparable safety for the treatment of acute seizure emergencies in pediatric patients.  Findings from the systematic review were presented at the 42nd Annual Child Neurology Society meeting in Austin, Texas, October 30 – November 2, 2013.  The systematic review was supported by Upsher-Smith Laboratories, Inc. (Upsher-Smith).

Benzodiazepines are considered effective rescue therapies for seizure emergencies, and although rectal diazepam gel is approved by the U.S. Food and Drug Administration (FDA), some children may prefer an alternative form of administration.  The systematic review of published literature suggests that intranasal midazolam may offer a convenient and socially acceptable alternative for children.

"Seizure emergencies, such as repetitive seizures or seizure clusters, typically require immediate action by a caregiver and often involve administering a rescue treatment," said Jack Pellock, M.D., study author, Chairman, Division of Child Neurology, Virginia Commonwealth University.  "Unfortunately, rescue treatment options for seizure clusters are very limited - the only FDA approved option is rectal diazepam, and this treatment may not be desirable for all age groups.  Currently, there are other products in development, such as intranasal midazolam, which may address this unmet need for a non-invasive rescue therapy."

The systematic review included the published results of randomized, prospective, active-comparator controlled, efficacy studies of intranasal midazolam studies in the treatment of acute seizure
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SOURCE Upsher-Smith
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