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Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions
Date:3/31/2008

Results of Mouse Model of Diabetes with Haptoglobin 2-2 Genotype Show Modification of HDL Structure and Defective Reverse Cholesterol Transport

MONTVALE, N.J., March 31 /PRNewswire-FirstCall/ -- Synvista Therapeutics, Inc. (Amex: SYI) announces data from a study of diabetic mice with the Haptoglobin 2-2 genotype that show impairment in the clearance of the Haptoglobin (Hp)-Hemoglobin (Hb) complex may result in a modification of high-density lipoprotein (HDL) structure and defective reverse cholesterol transport. These findings, which were presented today at the 57th Annual Scientific Sessions of the American College of Cardiology in Chicago, suggest the value of Haptoglobin testing in people with diabetes in order to ensure more successful treatment in the prevention of cardiovascular events (such as heart attack and stroke).

"These data from a validated animal model support our belief that Haptoglobin testing may help physicians tailor optimal therapy for patients with diabetes who may be at risk for cardiovascular events. The transport of cholesterol out of atherosclerotic plaque may be an important mechanism of stroke and heart attack prevention. Characterizing the functional impairment of HDL may help us understand how to intervene in Hp2-2 diabetic patients," said Noah Berkowitz, M.D., Ph.D., President and Chief Executive Officer of Synvista Therapeutics, which is developing a diagnostic product to identify Haptoglobin types. "As with previous studies of diabetic patients exhibiting markedly elevated cardiovascular risk, we believe that these findings support the notion of testing for Haptoglobin and treating the appropriate diabetic patients (Hp2-2) with vitamin E."

In the study, researchers assessed clearance of
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SOURCE Synvista Therapeutics, Inc.
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