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Synvista Therapeutics Announces Initiation of Phase 2 Study With Alagebrium for Chronic Heart Failure
Date:11/12/2007

nical development in this indication."

"Initiating the BENEFICIAL study is an important milestone in the development of alagebrium as a treatment for CHF," said Noah Berkowitz, M.D., Ph.D., President and Chief Executive Officer of Synvista Therapeutics. "This study will involve 9 months of treatment and we hope to announce results in 2009."

Alagebrium has been studied in two human heart failure trials: the DIAMOND trial in patients with diastolic heart failure; and the PEDESTAL trial in patients with systolic heart failure. While both trials provided encouraging results, each had an open-label design and thus neither was able to draw definitive conclusions about the effectiveness of alagebrium in heart failure.

About Heart Failure

Heart failure is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. The primary manifestations of heart failure are dyspnea and fatigue, which may limit exercise tolerance, result in fluid retention, and lead to pulmonary congestion and peripheral edema. These abnormalities impair the functional capacity and quality of life of affected individuals.

Heart failure is a major and growing global public health problem. Approximately 5 million patients in the U.S. and about 10 million in Europe have heart failure, according to the American Heart Association. The number of heart failure deaths has increased steadily despite advances in treatment. Heart failure results in more than 1 million hospitalizations at a cost of more than $15 billion annually in the U.S. alone.

Most of the available treatments for heart failure are not aimed at the underlying pathophysiological processes that occur in the heart and blood vessels. In this respect, the Company believes that accumulation of AGEs might prove to be a promising, novel target for the treatment of heart failure. AGEs are proteins formed by oxidativ
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SOURCE Synvista Therapeutics, Inc.
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