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Synvista Therapeutics Announces First Dosing of SYI-2074 in Clinical Trial for Psoriasis
Date:12/15/2008

pathway that can be inhibited by SYI-2074.

About Psoriasis

Psoriasis is an immune-mediated chronic inflammatory disease usually characterized by red lesions or silvery white scales on the skin, which usually occur on the scalp, knees, elbows, the abdomen (around the navel) and the genitals. In about a quarter of the cases, psoriasis can lead to psoriatic arthritis, another inflammatory disease affecting the joints.

While the exact cause of the disease is unknown, it is believed that both genetic and hormonal factors play a role. It is also known that the TNF-alpha pathway plays a role in the progression of the disease. Other companies have successfully developed drugs that also interfere with TNF-alpha signaling, but these similar drugs are given as injections and are indicated for more severe forms of the disease. Synvista intends to differentiate SYI-2074 by developing a topical formulation of the drug for the treatment of mild-to-moderate psoriasis.

About Synvista Therapeutics

Synvista Therapeutics is a biopharmaceutical company developing diagnostics and drugs to diagnose, treat and prevent cardiovascular disease in people with diabetes. The Company has developed a clinical laboratory test that identifies diabetic patients with the Haptoglobin genotype Hp2-2. The genetic or protein form of this test can be used to identify diabetic patients at high risk for cardiovascular complications. These patients may benefit from a particular formulation of vitamin E. The Company is also developing a test kit to measure CML (carboxy-methyllysine), another potential cardiovascular risk marker.

Synvista Therapeutics is developing oral antioxidant drugs to treat the HDL dysfunction seen in Hp2-2 diabetes, a disease affecting almost 7 million patients in the United States. The Company is also developing alagebrium, a proposed breaker of advanced glyca
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SOURCE Synvista Therapeutics, Inc.
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2. Synvista Therapeutics Reports Results of Three Phase 2 Clinical Trials of SYI-2074 in Diabetic Patients with Cardiovascular Disease
3. Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions
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