Navigation Links
Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes
Date:11/5/2007

MONTVALE, N.J., Nov. 5 /PRNewswire-FirstCall/ -- Synvista Therapeutics, Inc. (Amex: SYI) announced results of a series of preclinical studies designed to explain the mechanism underlying dysfunctional high density lipoprotein (HDL), that creates a defect in reverse cholesterol transport in patients with Diabetes Mellitus (DM). The studies reveal that a common blood protein, Haptoglobin, binds to the core of HDL and that a defective Haptoglobin variant (Hp2-2), found in 40% of the population, may induce dysfunctionality in HDL. Further, the studies report that exposure to Vitamin E can restore HDL functionality and the process of reverse cholesterol transport. The study is being presented today at the American Heart Association's (AHA) Scientific Sessions 2007 in Orlando, Florida.

"We are very pleased with the outcome of these studies, as we believe they provide scientific rationale for our current development platform, including our work developing a diagnostic test for Haptoglobin type, to determine cardiovascular risk and a therapeutic product to decrease HDL oxidation and restore reverse cholesterol transport function," said Noah Berkowitz, M.D., Ph.D., President and Chief Executive Officer of Synvista. "This study further demonstrates that the Hp2-2 phenotype, a risk factor for cardiovascular events in patients with diabetes, may function by interfering with the function of HDL and promoting inflammatory atherosclerosis."

The experiments of Rabea Asleh, M.D., of the Rappaport Faculty of Medicine and Research Institute, at the Technion, Haifa, Israel, who is today's recipient of the AHA's Council on Nutrition, Physical Activity and Metabolism's 2007 New Investigator Award, provided a mechanistic explanat
'/>"/>

SOURCE Synvista Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Synvista Therapeutics Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications
2. Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing
3. LigoCyte Pharmaceuticals Announces Collaboration With Biogen Idec to Develop Anti-CD103 Therapies
4. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
5. Quark Pharmaceuticals Signs Collaboration Agreement With University of Michigan for Development of Proprietary SiRNA Compounds for Noise-Induced Hearing Loss
6. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
7. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
8. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
9. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
10. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
11. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... -- Zipnosis, the first virtual care solution to empower health care ... branded virtual care service line, announced an agreement with ... currently in use. ... As health systems consider how ... of providing their own branded online care for common medical ...
(Date:7/28/2015)... , July 28, 2015 ANI Pharmaceuticals, ... Company plans to release its second quarter and year-to-date ... the opening of the U.S. financial markets. The earnings ... section of the Company,s website, www.anipharmaceuticals.com . ... Executive Officer, and Charlotte C. Arnold , Vice ...
(Date:7/28/2015)... Egalet Corporation (Nasdaq: EGLT ) ... on developing, manufacturing and marketing innovative pain treatments, ... offering of 6,666,667 shares of its common stock ... share. The gross proceeds to Egalet from this ... before deducting the underwriting discounts and commissions and ...
Breaking Medicine Technology:Zipnosis Announces Group Health to use Virtual Care Service Line 2Zipnosis Announces Group Health to use Virtual Care Service Line 3ANI Pharmaceuticals Schedules Conference Call for Second Quarter and Year-to-Date 2015 Financial Results 2Egalet Announces Pricing of Public Offering of Common Stock 2Egalet Announces Pricing of Public Offering of Common Stock 3Egalet Announces Pricing of Public Offering of Common Stock 4
... SAN JOSE, Calif., Nov. 15, 2010 SI-BONE, Inc. ... pioneering the use of a minimally invasive surgical (MIS) ... that it has received a CE mark for its ... assurance certification requirement recognized by members of the European ...
... Texas, Nov. 15, 2010 ULURU Inc. (NYSE Amex: ... ended September 30, 2010. For the third quarter of 2010, ... share, compared with a net loss of $1.5 million, or $0.02 per ... September 30, 2010, the Company reported a net loss of $4.7 million, ...
Cached Medicine Technology:iFuse Implant System™ Receives CE Mark 2iFuse Implant System™ Receives CE Mark 3ULURU Inc. Reports Third Quarter 2010 Financial Results 2ULURU Inc. Reports Third Quarter 2010 Financial Results 3ULURU Inc. Reports Third Quarter 2010 Financial Results 4ULURU Inc. Reports Third Quarter 2010 Financial Results 5
(Date:7/28/2015)... ... 28, 2015 , ... A new Taiwanese study suggests that ... in the general population. Surviving Mesothelioma has just posted an article detailing the ... Taiwan’s National Health Research Institutes and three Taiwanese universities evaluated the health records ...
(Date:7/28/2015)... ... , ... A new study published by HealthDay News on June 24, 2015, ... a possible new treatment option for people living with fibromyalgia – hyperbaric oxygen therapy ... five per week, patients experienced a significant decrease in pain, fatigue, and other symptoms ...
(Date:7/28/2015)... CO (PRWEB) , ... July 28, 2015 , ... There ... While most people think of highways, bridges and railroads, often overlooked is the over ... of our homes and buildings and into sewage treatment facilities. According to the ...
(Date:7/28/2015)... ... ... for the 5th Annual Step for Hope 5K Run/Walk on Saturday, September 12, ... Carol Stream. All are welcome. , Now in its 5th year, the Step for ... and families affected by a brain aneurysm. , “We look forward to you joining ...
(Date:7/28/2015)... ... July 28, 2015 , ... American ... RN to BSN cohorts for Geisinger Health System (GHS), one of the ... and associate degree prepared nurses with access to American Sentinel’s affordable, flexible and ...
Breaking Medicine News(10 mins):Health News:New Findings Suggest Mesothelioma is Not the Only Cancer Threat for Shipbreakers, According to Surviving Mesothelioma 2Health News:Recovery Specialists Discuss How Oxygen Therapy Can Ease Fibromyalgia 2Health News:Recovery Specialists Discuss How Oxygen Therapy Can Ease Fibromyalgia 3Health News:With an Infrastructure Spending Bill on the Horizon, RestorationEze Discusses the Impact an Aging Sewer System is Having on Homeowners 2Health News:With an Infrastructure Spending Bill on the Horizon, RestorationEze Discusses the Impact an Aging Sewer System is Having on Homeowners 3Health News:5th Annual Step for Hope 5K Run/Walk Event in Carol Stream, IL to Benefit Renowned Brain Aneurysm Foundation 2Health News:American Sentinel University Selected to Provide Online RN to BSN Cohorts to Geisinger Health System 2Health News:American Sentinel University Selected to Provide Online RN to BSN Cohorts to Geisinger Health System 3Health News:American Sentinel University Selected to Provide Online RN to BSN Cohorts to Geisinger Health System 4
... Ind., Aug. 27 Zimmer Holdings, Inc.,(NYSE ZMH; SWX: ... will be participating in the Thomas Weisel Partners Healthcare,Conference ... 8:35,a.m. Eastern Time., A live webcast of the ... http://investor.zimmer.com . The webcast will,be archived for ...
... insulin-resistant proteins, study says , , WEDNESDAY, Aug. 27 (HealthDay News) ... those in lean people, a new study shows. , ... group of researchers from the Temple University School of Medicine ... and six obese people. , They found significant differences in ...
... form of the eye disease , , WEDNESDAY, Aug. 27 ... China have identified the first gene directly associated with ... two forms of age-related macular degeneration that currently threatens ... , The discovery, based on work with both human ...
... Texas, Aug. 27 SBTI, a global management,consulting ... operating company,called SBTI Europe GmbH to be located ... services, SBTI is strengthening its position in Europe ... GmbH is a wholly owned subsidiary of Sigma ...
... normal aging process , , WEDNESDAY, Aug. 27 (HealthDay News) -- ... of dementia will nonetheless undergo an accelerated drop in key ... a new study reveals. , Verbal ability, spatial reasoning and ... which is not, the researchers stressed, a routine part of ...
... Services, LLC, WARP,Robotics, LLP, and Planet Earth Engineering, LLP ... South Carolina Corporation today,announced that the company has reached ... through the month of September., Patrick & Sharalyn ... a subsidiary of WARP Services, LLC are delighted at ...
Cached Medicine News:Health News:Gene Linked to 'Dry' Macular Degeneration 2Health News:Gene Linked to 'Dry' Macular Degeneration 3Health News:Sigma Breakthrough Technologies, Inc. (SBTI) Is Expanding Its Service Offering for Global Clients by Announcing the Public Listing of SBTI Europe GmbH 2Health News:Mental Skills Can Decline Years Before Dying 2Health News:Mental Skills Can Decline Years Before Dying 3Health News:Habitat for Humanity and WARP Robotics Team Up 2Health News:Habitat for Humanity and WARP Robotics Team Up 3
... care challenge., ,The S/5 Critical Care Monitor ... solution for the varying needs of critical care. ... of parameter module options, display and mounting options, ... optimize the bedside set-up to help meet your ...
... connectivity, ,The wireless functionality is an ... that makes it possible to connect S/5 ... S/5 Central Station via Wireless LAN technology., ... of providing continuous centralized surveillance within the ...
... day surgery and post anesthesia care in one ... is a high performance monitor designed for the ... and induction rooms. It offers the flexibility of ... advanced airway gas monitoring. When paired with the ...
Anesthetists Precordial Kit incudes one set of 4 chromed plated chest pieces, a reusable monoscope of your choice, and 20 precordial adhesive discs....
Medicine Products: