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Syndax and Eddingpharm Enter into a License Agreement Giving Eddingpharm Rights to Commercialize Entinostat in China and Other Asian Countries
Date:9/4/2013

and we believe this partnership with Syndax has the potential to help a large number of cancer patients across our Asian markets."

Arlene M. Morris, Syndax's chief executive officer added, "We view this agreement as the start of an important collaborative effort between our two companies. The agreement to a joint development committee, trial participation and sharing of data represents Eddingpharm's important commitment to that effort. The result will be a cooperative effort that has the potential to impact many patients in China suffering with advanced, treatment-resistant cancers."

About Entinostat

Entinostat, Syndax's lead product candidate, has been studied in more than 800 cancer patients where objective tumor responses have been observed in both solid and hematologic malignancies. Entinostat's established safety and efficacy profile as both a single agent and in combination with a number of commercially available targeted therapies differentiates it from other histone deacetylase inhibitors(HDACi). Having demonstrated promising clinical results in breast and lung cancer, entinostat is moving toward pivotal clinical testing. It is an oral, novel inhibitor of class I histone deacetylases, key enzymes that alter the structure of chromatin to control gene expression. This aberrant gene expression can result in reversible, epigenetically-based drug tolerance. Designed to selectively target the HDAC isoforms most relevant to the biology of tumors, entinostat can normalize dysregulated gene expression in cancer cells, thereby restoring sensitivity to targeted therapy. Entinostat is the first HDACi with positive results in a randomized Phase 2 study in breast cancer and is the only HDACi in late-stage development for this indication.

About Eddingpharm

Founded in 2001, Eddingpharm is a leading specialty pharmaceutical compan
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SOURCE Syndax Pharmaceuticals Inc.
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