Navigation Links
Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
Date:5/29/2012

d States and there are approximately 150,000 women living with metastatic breast cancer (MBC).  Over 70 percent of women with breast cancer have estrogen receptor-positive (ER+) breast cancer.  The most effective cancer treatments target the underlying biology and in breast cancer the most common oncogenic driver is estrogen receptor signaling.  Blocking estrogen activity with aromatase inhibitors represents an effective treatment for most ER+ MBC patients, however acquired drug resistance to aromatase inhibitors leads to disease progression, ultimately requiring less effective, more toxic chemotherapies. Delaying resistance and disease progression represents a significant unmet need that could prolong survival while decreasing health care costs associated with chemotherapy and hospitalization.

About Entinostat

Syndax's lead product entinostat is a novel, oral small molecule inhibitor of class I histone deacetylases, key enzymes that alter the structure of chromatin to control gene expression. Entinostat is differentiated from other members of the class through its unique selectivity profile, pharmacokinetic properties and safety profile. Entinostat has been studied in more than 700 cancer patients where objective tumor responses have been observed in both solid and hematologic malignancies. Preclinical studies have demonstrated that entinostat can overcome resistance to a wide variety of targeted therapies including hormone therapy, receptor tyrosine kinase inhibitors, and chemotherapy.

Additional phase 2 studies with entinostat have demonstrated promising results in combination with the EGFR-TKI erlotinib (ENCORE 401) in non-small cell lung cancer (NSCLC), in combination with the DNA methyltransferase inhibitor azacitidine in NSCLC and as a single agent in Hodgkin's  lymphoma (ENGAGE 501).  Res
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Syndax Pharmaceuticals Entinostat Shows Clinical Promise in Patients with Advanced Hormone Refractory Breast Cancer
2. Syndax Pharmaceuticals to Present at Sachs Biotech in Europe Investor Forum
3. Syndax Pharmaceuticals Announces Issuance of UK Patent for Entinostat
4. Syndax Pharmaceuticals Entinostat Plus Erlotinib Improves Survival in Select NSCLC Patients
5. Syndax Pharmaceuticals Entinostat in Combination Shows Activity in Breast Cancer
6. Syndax Pharmaceuticals to Present at Biotech Showcase 2011
7. Syndax Announces Publication of Entinostat NSCLC Data in Cancer Research
8. Syndax Announces Start of NCI Sponsored Phase 2 Study of Entinostat in Combination in Triple Negative Breast Cancer
9. Syndax Pharmaceuticals Announces Entinostat Data at 102nd Annual American Association for Cancer Research Meeting
10. Syndax Pharmaceuticals Announces Issuance of US Patent for Entinostat
11. Syndax Pharmaceuticals Elects Arlene Morris to Board of Directors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... 2015 According to a new market research ... Universal, Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage Type (Disposable, ... by MarketsandMarkets, the Medical Lifting Sling Market is poised to reach ... at a CAGR of 11.4 % from 2015 to 2020. ... rket data T ables and 65 ...
(Date:8/27/2015)...  Now that Intuitive Surgical, Inc.® has announced that ... hospitals with robotic surgery programs need to think about ... where they stand with robotic surgery. Are they performing ... adopted best practices for safety? Should they plan to ... ECRI Institute, which has nearly 50 years, experience ...
(Date:8/27/2015)... Ala. , Aug. 27, 2015 /PRNewswire/ ... Outpatient Pharmacy Provider (IOPP™) is expanding its ... of a medication-focused transition of care program ... named "RxCare Management," provides hospitals with technology ... hospital performance measures that have been mandated ...
Breaking Medicine Technology:Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 2ECRI Institute's New Robotic Surgery Service Helps Hospitals Brace for Change 3Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2
... June 9, 2011 /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. ... "Company"), a developer, manufacturer and distributor of botanical products, ... it will host a conference call at 9:00 a.m. ... financial results for the second quarter of fiscal year ...
... 9, 2011 Reportlinker.com announces that a new ... South and Central America Dental ... http://www.reportlinker.com/p0548448/South-and-Central-America-Dental-Devices-Market-Outlook-to-2017.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Dental_Equipment South and Central ... Summary GlobalData,s new ...
Cached Medicine Technology:China Botanic Schedules Conference Call to Discuss FY 2011 Second Quarter Results 2Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 2Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 3Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 4Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 5Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 6Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 7Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 8Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 9Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 10Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 11Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 12Reportlinker Adds South and Central America Dental Devices Market Outlook to 2017 13
(Date:8/28/2015)... , ... August 28, 2015 ... ... Inc.’s (AIS) Medicare-Medicaid Dual Eligibles Database have added comprehensive information on two ... demonstration approved for a December 2015 launch; and Idaho’s partnership to revamp ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... organization, is pleased to welcome TJS Insurance Group as its newest Partner Firm. ... clients guides them and keeps them focused on their goals. Within the past ...
(Date:8/28/2015)... ... August 28, 2015 , ... Popular review ... millionaire dating sites . According to the listings, MillionaireMatch.com bags ... this category. , A spokesperson of Top5MillionaireDatingSites.com said, “This website has ...
(Date:8/28/2015)... Calgary, AB (PRWEB) , ... August 28, 2015 , ... ... disease. The Heart Fit Clinic is now selling External Counterpulsation (EECP or ECP) machines ... The Heart Fit Clinic has been in business since 2007 helping people prevent and ...
(Date:8/28/2015)... ... August 28, 2015 , ... The Plaintiffs Steering Committee ... 2545, Testosterone Replacement Therapy Products Liability Litigation, are in the midst of ongoing ... the PSC may receive for corporate employees involved in the production or marketing ...
Breaking Medicine News(10 mins):Health News:AIS Duals Database: August Update Finds Two New Duals Programs in Rhode Island and Idaho 2Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 2Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 3Health News:Top5MillionaireDatingSites.com Publishes Its First List of Reviews of the Best Millionaire Dating Sites 2Health News:Buy New External Counterpulsation (EECP or ECP) With Heart Fit Clinic 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 3Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 4
... ... renowned author, clinician and educator announces the signing of a joint marketing agreement with ... , ... June 18, 2010 -- The Dawson Academy ( www.thedawsonacademy.com ), founded by ...
... ... used as a barometer for hiring this fall, we are about to see a significant pickup ... (PRWEB) June ... to be a leading indicator for future hiring activity. “It only makes sense, says RD Whitney, ...
... ... a sponsor of the annual fundraising MS Luncheons held in Wisconsin which help support families ... Quincy Bioscience recently launched MS HOPE Trials which will investigate how its patented calcium-binding technology ... ...
... ... Present the Life Ball 2010 Fashion Show , ... (PRWEB) June 17, 2010 -- Life Ball 2010 will be held in ... Vienna City Hall Square, as well as thousands of people around the world. The fashion ...
... death rates in sub-Saharan Africa has led to a burgeoning ... elderly, or older adults living alone without the benefit of ... The researchers used existing data to develop the first ... any adult support, as a result of the AIDS epidemic, ...
... to thyroid experts , THURSDAY, June 17 (HealthDay News) ... worry that some may obtain too little iodine. , ... in the U.S. and worldwide. Iodine, essential for the ... several members of the American Thyroid Association wrote in ...
Cached Medicine News:Health News:The Dawson Academy Announces the Signing of a Joint Marketing Agreement with Ads Next™ 2Health News:The Dawson Academy Announces the Signing of a Joint Marketing Agreement with Ads Next™ 3Health News:Onrec Predicts Significant Recruiting Activity this Fall 2Health News:Onrec Predicts Significant Recruiting Activity this Fall 3Health News:Onrec Predicts Significant Recruiting Activity this Fall 4Health News:Quincy Bioscience Sponsors Multiple Sclerosis (MS) Scholarship Program 2Health News:Life Ball: Designers Joining Together in the Fight Against AIDS 2Health News:Life Ball: Designers Joining Together in the Fight Against AIDS 3Health News:Life Ball: Designers Joining Together in the Fight Against AIDS 4Health News:Life Ball: Designers Joining Together in the Fight Against AIDS 5Health News:Orphaned elderly serious casualty of African AIDS epidemic, Stanford study finds 2Health News:Orphaned elderly serious casualty of African AIDS epidemic, Stanford study finds 3Health News:Iodine Levels a Worry as Salt Use Declines 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: