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Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
Date:5/29/2012

d States and there are approximately 150,000 women living with metastatic breast cancer (MBC).  Over 70 percent of women with breast cancer have estrogen receptor-positive (ER+) breast cancer.  The most effective cancer treatments target the underlying biology and in breast cancer the most common oncogenic driver is estrogen receptor signaling.  Blocking estrogen activity with aromatase inhibitors represents an effective treatment for most ER+ MBC patients, however acquired drug resistance to aromatase inhibitors leads to disease progression, ultimately requiring less effective, more toxic chemotherapies. Delaying resistance and disease progression represents a significant unmet need that could prolong survival while decreasing health care costs associated with chemotherapy and hospitalization.

About Entinostat

Syndax's lead product entinostat is a novel, oral small molecule inhibitor of class I histone deacetylases, key enzymes that alter the structure of chromatin to control gene expression. Entinostat is differentiated from other members of the class through its unique selectivity profile, pharmacokinetic properties and safety profile. Entinostat has been studied in more than 700 cancer patients where objective tumor responses have been observed in both solid and hematologic malignancies. Preclinical studies have demonstrated that entinostat can overcome resistance to a wide variety of targeted therapies including hormone therapy, receptor tyrosine kinase inhibitors, and chemotherapy.

Additional phase 2 studies with entinostat have demonstrated promising results in combination with the EGFR-TKI erlotinib (ENCORE 401) in non-small cell lung cancer (NSCLC), in combination with the DNA methyltransferase inhibitor azacitidine in NSCLC and as a single agent in Hodgkin's  lymphoma (ENGAGE 501).  Res
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SOURCE Syndax Pharmaceuticals, Inc.
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