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Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
Date:5/29/2012

ultiple subsets of interest demonstrated a consistent benefit in the exemestane and entinostat (EE) group versus exemestane and placebo (EP);
  • Sensitivity analysis of baseline characteristics potentially impacting OS did not identify any factors that influenced the effect of EE on OS;
  • Examination of treatments received during follow-up after discontinuation of EE and EP demonstrated balance between treatment group for patients receiving chemotherapy (48% EE: 44% EP), hormone therapy (37% EE: 35% EP), bisphosphonates (2% EE; 0% EP), radiation (6% EE; 5%EP), and surgery (0% EE: 2% EP);
  • Compared to EP, OS was longer in EE group for patients whose first subsequent treatment was a hormone therapy (EE median not reached vs EP median 20.5 months; HR 0.65 [95% CI 0.26, 1.58]) or chemotherapy (EE median 26.9 months vs EP median 17.6 months; HR 0.51 [95% CI 0.25, 1.04])
  • "The metastatic breast cancer community needs new treatment options that can improve survival," said Joanna Horobin, MD, president of Syndax.  "We are hopeful that the positive data we have seen so far in the randomized, phase 2 clinical trial will be confirmed in the phase 3 study.  If positive, entinostat would be the first epigenetic therapy to benefit patients with solid tumors, representing not only an important new treatment option for women with ER positive MBC but a significant commercial opportunity for Syndax."

    In addition to the breast cancer data, an abstract highlighting the immunomodulatory effects of entinostat entitled, "Phase I/II study of high-dose interleukin 2, aldesleukin, in combination with the histone deacetylase inhibitor entinostat in patients with metastatic renal cell carcinoma" will be presented in a poster session on Sunday, June 3 from 8:00 AM to 12:00 PM CT. 

    Breast Cancer and Hormone Therapy

    Approximately 230,000 new cases of invasive breast cancer are diagnosed in women annually in the Unite
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    SOURCE Syndax Pharmaceuticals, Inc.
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    All rights reserved

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