Navigation Links
Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
Date:5/29/2012

WALTHAM, Mass., May 29, 2012 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a late-stage oncology company, announced today that updated results from ENCORE 301, a randomized, placebo-controlled phase 2 study of exemestane with and without entinostat in estrogen receptor positive metastatic breast cancer demonstrated improvement in overall survival for patients treated with exemestane plus entinostat. At median follow up of 25 months, treatment with the combination resulted in an 8.3 months improvement in overall survival (an exploratory endpoint) corresponding to a 41% reduction in the risk of dying (p = 0.04). Updated safety and efficacy results from the trial will be presented in a poster session at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, IL on Saturday, June 2, 2012.   

Previously reported results indicated the study met the designated primary endpoint of progression-free survival (PFS) (4.28 versus 2.27 months, respectively; hazard ratio (HR = 0.73; p=0.06).  Additionally, in the subset of patients assessed for the pharmacodynamic marker of protein lysine acetylation in peripheral blood cells, acetylation in entinostat-treated patients was associated with prolonged progression-free survival to over six months across all peripheral mononuclear cell types analyzed.                 

"Entinostat combined with exemestane extends the lives of post-menopausal women with estrogen-receptor positive MBC as compared to those women that received exemestane combined with placebo and ongoing analyses of the data has not identified any contributing factors beyond the potential contribution of entinostat to account for the extended
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Syndax Pharmaceuticals Entinostat Shows Clinical Promise in Patients with Advanced Hormone Refractory Breast Cancer
2. Syndax Pharmaceuticals to Present at Sachs Biotech in Europe Investor Forum
3. Syndax Pharmaceuticals Announces Issuance of UK Patent for Entinostat
4. Syndax Pharmaceuticals Entinostat Plus Erlotinib Improves Survival in Select NSCLC Patients
5. Syndax Pharmaceuticals Entinostat in Combination Shows Activity in Breast Cancer
6. Syndax Pharmaceuticals to Present at Biotech Showcase 2011
7. Syndax Announces Publication of Entinostat NSCLC Data in Cancer Research
8. Syndax Announces Start of NCI Sponsored Phase 2 Study of Entinostat in Combination in Triple Negative Breast Cancer
9. Syndax Pharmaceuticals Announces Entinostat Data at 102nd Annual American Association for Cancer Research Meeting
10. Syndax Pharmaceuticals Announces Issuance of US Patent for Entinostat
11. Syndax Pharmaceuticals Elects Arlene Morris to Board of Directors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Sept. 30, 2014  Allakos Inc. announced today ... investment from current investors to fund development of ... completed following achievement of a key, pre-specified milestone ... represents an extension of the company,s Series A ... With this additional financing, Allakos has raised a ...
(Date:9/29/2014)... and DUBLIN , Sept. 29, 2014 ... "Company"), a biotechnology company pioneering the manufacturing both US ... therapies for cancer, HIV/AIDS, opportunistic infections and autoimmune diseases ... from CEO Noreen Griffin The letter follows: ... or "TNIB") received a number of calls from shareholders ...
(Date:9/29/2014)... EU5 Capsule Endoscopy Systems Market Outlook to ... report, "EU5 Capsule Endoscopy Systems Market Outlook to 2020", ... Systems market. The report provides value, in millions of ... US dollars) within market segments - Capsule Endoscopes, Capsule ... The report also provides company shares and distribution shares ...
Breaking Medicine Technology:Allakos Inc. Raises Additional $10 Million to Expand its Portfolio and Fund Development of an Additional Antibody for Allergic and Inflammatory Diseases 2Allakos Inc. Raises Additional $10 Million to Expand its Portfolio and Fund Development of an Additional Antibody for Allergic and Inflammatory Diseases 3Allakos Inc. Raises Additional $10 Million to Expand its Portfolio and Fund Development of an Additional Antibody for Allergic and Inflammatory Diseases 4TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 2TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 3TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 4TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 5TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 6TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 7TNI BioTech, Inc. Corporation's CEO Issues Letter to Shareholders Discussing Cytocom Dividend 8EU5 Capsule Endoscopy Systems Market Outlook to 2020 2EU5 Capsule Endoscopy Systems Market Outlook to 2020 3
... VIEJO, Calif., May 14, 2012  Bausch + Lomb, ... Barr Global President of the company,s Surgical business.  ... full suite of ophthalmic surgical products, intraocular lenses ... names as enVista™ Crystalens®, Stellaris® ...
... N.Y., May 14, 2012   Pharmaceutical manufacturers and ... requiring reporting on drug product samples distribution using XML, ... To help the pharmaceutical industry cope with the ... for ongoing Standard SPL filings, Data Conversion Laboratory (DCL) ...
Cached Medicine Technology:Bausch + Lomb Names John Barr Global President Surgical 2Bausch + Lomb Names John Barr Global President Surgical 3Coping With New FDA Mandates For Drug Sample Distribution 2
(Date:9/30/2014)... 2014 Julie Kuriakose, MD; ... , will discuss how restaurants can become more allergy-friendly ... dietary restrictions at the 2014 Allergy Eats Food ... October 21 in New York City. , “I’m extremely ... to such an engaged industry audience. As food allergies ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 In ... well as better data capture and management functions ... ClinCapture electronic data capture (EDC) system. ClinCapture offers ... ability to easily manage clinical trial data and ... cement Synergy’s position as the leading clinical research ...
(Date:9/30/2014)... From October 12-15, MMS, Inc. (Medical ... SHSMD Connections Annual Conference in San Diego, California. ... Development (SHSMD) is proud to host the event of ... and strategic planning professionals in San Diego this fall: ... conference is a four-day event designed to equip ...
(Date:9/30/2014)... Bibliomotion is proud to announce the release of ... Social Age by Frank Guglielmo and Sudhanshu ... authors apply their leadership coaching experience to introduce Social Leadership ... and behaviors that leaders must adopt in order to thrive ... read a review of The Social Leader in Dialogue Reviews. ...
(Date:9/30/2014)... JACKSON, Tenn. (PRWEB) September 30, 2014 ... Oct. 4, from 10 a.m. to 2 p.m. at ... Pinson). Woodmen of the World sponsors this family-oriented festival, ... free, and the festival will feature a car show, ... climbing wall, hayride and children’s games. Also, Lightning McQueen ...
Breaking Medicine News(10 mins):Health News:Hudson Allergy’s Dr. Julie Kuriakose to Speak at Prestigious Food Allergy Conference in New York City 2Health News:Hudson Allergy’s Dr. Julie Kuriakose to Speak at Prestigious Food Allergy Conference in New York City 3Health News:Synergy Research Group Opts for Clinovo 2Health News:Synergy Research Group Opts for Clinovo 3Health News:MMS, Inc. (Medical Marketing Service) to Attend the 2014 SHSMD Connections Annual Conference in October 2Health News:The Social Leader: new Bibliomotion book redefines leadership for the Social Age 2Health News:The Social Leader: new Bibliomotion book redefines leadership for the Social Age 3Health News:The Social Leader: new Bibliomotion book redefines leadership for the Social Age 4Health News:The Social Leader: new Bibliomotion book redefines leadership for the Social Age 5Health News:The Social Leader: new Bibliomotion book redefines leadership for the Social Age 6
... coverage and other problems persist, analysis shows, , WEDNESDAY, July ... access to prescription drug coverage has ballooned since Medicare,s Part ... new analysis finds, yet seniors, ability to pay for needed ... rising drug plan costs. , "Based on nearly four years ...
... in the regulation of cell death has been identified ... led them to recommend caution when drugs called IAP ... liver conditions. , A team led by Professor Andreas ... has found that XIAP (X-chromosome-linked inhibitor of apoptosis protein) ...
... , Presidential Health Advisor , s Writings Support ... DALLAS, July 22 On the cusp of President Obama,s news conference tonight, ... care reform plan may result in denying care to a significant number of ... Administration does not consider doctors the best judges of the type of health ...
... WEDNESDAY, July 22 (HealthDay News) -- One part of the ... when deadly plaque builds up, but two other sections don,t, ... Wake Forest University Baptist Medical Center have found. , ... and left carotid arteries expands by 11 percent, on average, ...
... , , LANTANA, Fla., July ... (IHPA), announced today the launching of the , ... Get the Number , campaign is an ... for when buying storm and hurricane protection," Johnston said. "Consumers ...
... , , OAK BROOK, ... gastroenterologists, gastroenterology nurses and gastroenterology fellows, announces enhanced site content ... , , NAAP describes the ... of a physician, or by a physician or nurse other ...
Cached Medicine News:Health News:Medicare Drug Plan Still Needs Work 2Health News:Medicare Drug Plan Still Needs Work 3Health News:Critical link in cell death pathway revealed 2Health News:NCPA: White House Has Ideas on How to Ration Health Care 2Health News:Carotid Artery Sections React Differently to Plaque 2Health News:IHPA Launches Consumer Awareness Campaign for Hurricane Protection 2Health News:IHPA Launches Consumer Awareness Campaign for Hurricane Protection 3Health News:SedationFacts.org Presents Content on Policies and Conditions Regarding Alternative Methods for the Administration of Propofol 2Health News:SedationFacts.org Presents Content on Policies and Conditions Regarding Alternative Methods for the Administration of Propofol 3Health News:SedationFacts.org Presents Content on Policies and Conditions Regarding Alternative Methods for the Administration of Propofol 4