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Syndax Pharmaceuticals Signs Agreement with Ventana Medical Systems, Inc. to Develop Companion Diagnostic Test for Entinostat
Date:1/5/2012

WALTHAM, Mass. and TUCSON, Ariz., Jan. 5, 2012 /PRNewswire/ -- Syndax Pharmaceuticals, Inc. and Ventana Medical Systems, Inc. announced that the companies have entered into an agreement to develop a companion diagnostic assay to select patients with non-small cell lung cancer (NSCLC) for treatment with erlotinib and Syndax's proprietary lead molecule entinostat. 

"Syndax is pleased to partner with Ventana, a world leader and innovator of tissue-based diagnostic solutions for patients worldwide, as we advance the development of entinostat in NSCLC," said Joanna Horobin, MD, president and chief executive officer of Syndax.  "In ENCORE 401, a randomized, phase 2 study comparing erlotinib plus entinostat to erlotinib plus placebo, the subset of patients with tumors expressing high levels of the protein E-cadherin experienced a more favorable overall survival and we therefore intend to select this patient population in the confirmatory study planned to start in the second half of the year." 

Data from ENCORE 401 presented most recently at the 2011 World Conference on Lung Cancer indicated that a subset of advanced non-small cell lung cancer patients expressing high levels of the protein e-cadherin in their tumors derived a 4-month survival advantage with the combination treatment versus erlotinib plus placebo (HR 0.35 [95% CI:0.13-0.92] p=0.03).

In 2010, Ventana developed and launched an in vitro diagnostic kit for use on VENTANA platforms to measure levels of E-cadherin in epithelial tissues.  Ventana plans to validate the assay in its own in-house CAP/ CLIA certified laboratory and may then serve as the central laboratory for the upcoming Syndax clinical trial.

"We are very pleased to be the companion diagnostic partner of choice for Syndax to collaborate on this important project," said Ventana President, Mara G. Aspinall. "The plan to develop a companion diagnostic for ent
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SOURCE Syndax Pharmaceuticals, Inc.
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