Navigation Links
Syndax Pharmaceuticals' Entinostat Shows Clinical Promise in Patients with Advanced Hormone Refractory Breast Cancer
Date:6/4/2010

WALTHAM, Mass., June 4 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, reported final results from the Phase 2, open-label ENCORE 303 trial in post-menopausal women with advanced, estrogen receptor (ER) positive breast cancer who were progressing on aromatase inhibitor (AI) therapy. Safety and efficacy results from the trial will be presented in a poster at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, IL tomorrow, Saturday, June 5, 2010.

"These findings are significant given that the patients enrolled were heavily hormonally pre-treated and relatively hormone resistant," said Joanna Horobin, president and chief executive officer of Syndax. "Resistance to AI therapy is multi-factorial and involves up-regulation of growth factor signaling pathways and down-regulation of estrogen receptor expression which may result from epigenetic modifications to the DNA and associated proteins. The disease stabilization achieved with the addition of entinostat supports our hypothesis that entinostat has the ability to normalize gene expression, thereby restoring sensitivity to targeted agents. We are optimistic that our ongoing ENCORE 301 study, a double-blind, randomized, placebo-controlled phase 2 study of entinostat in combination with the aromatase inhibitor exemestane, will provide further evidence supporting the clinical benefit and tolerability of entinostat in combination with aromatase inhibitors."

The primary endpoint of the study was Clinical Benefit Rate (CBR), defined as the proportion of patients who experience a complete or partial response or stable disease (SD) during the first six cycles of study treatment. Of the 26 evaluable patients in the ENCORE 303 stu
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Jiangbo Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Global Market
2. Cumberland Pharmaceuticals to Present at the Wells Fargo Healthcare Conference in Boston on June 23, 2010
3. Alexza Pharmaceuticals to Present at Jefferies 2010 Global Life Sciences Conference
4. Hospira Announces Further Extension of Tender Offer for Shares of Javelin Pharmaceuticals
5. Oramed Pharmaceuticals Forms Joint Venture - Launches Entera Bio Ltd.
6. Jazz Pharmaceuticals to Present at the Jefferies 2010 Global Life Sciences Conference
7. Amylin Pharmaceuticals Appoints Christian Weyer, MD Senior Vice President, Research and Development
8. Shire Receives LIALDA(R) Paragraph IV Notice Letter From Zydus Pharmaceuticals
9. China Yongxin Pharmaceuticals Announces 1-for-12 Reverse Stock Split
10. ISTA Pharmaceuticals to Present at the Jefferies 2010 Global Life Sciences Conference
11. Isis Pharmaceuticals to Present a General Corporate Update at Its 2010 Annual Meeting of Stockholders and Open House
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Oct. 22, 2014  AcelRx Pharmaceuticals, Inc. (NASDAQ: ... from the  IAP310 study have been published in ... a peer-reviewed journal with broad, multidisciplinary readership. IAP310 ... the safety and efficacy of Zalviso, also referred ... for the treatment of post-operative pain in patients ...
(Date:10/20/2014)... Oct. 20, 2014  PneumRx, Inc. ( www.pneumrx.com ), ... announced completion of enrollment in their RENEW Study, nearly ... is the FDA-approved IDE pivotal trial for the PneumRx ... It was anticipated that the study, which began ... take until the end of 2014 to enroll 315 ...
(Date:10/20/2014)... Oct. 20, 2014  ResMed (NYSE: ... ResMed Data Exchange program, a comprehensive suite of ... (HME) and other health care providers. ... to critical patient information. It integrates valuable sleep ... U-Sleep™ patient management platforms with customers, in-house or ...
Breaking Medicine Technology:AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2PneumRx Completes RENEW Pivotal Trial Enrollment 2PneumRx Completes RENEW Pivotal Trial Enrollment 3ResMed Launches ResMed Data Exchange 2
... Reportlinker.com announces that a new market ... Growth Hormone Deficiency Global ... http://www.reportlinker.com/p0567405/Growth-Hormone-Deficiency-Global-Clinical-Trials-Review-Q2-2011.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Discovery_and_Development Growth ... 2011 Summary ...
... 2011 ImpactRx, the pioneer in ... behavior, offers pharmaceutical brand managers unique insight into ... proprietary database, ImpactData™, annually captures more than 250,000 ... physicians, treatment behavior in response to these requests ...
Cached Medicine Technology:Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 2Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 3Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 4Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 5Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 6Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 7Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 8Growth Hormone Deficiency Global Clinical Trials Review, Q2, 2011 9ImpactRx Measures How Patient Brand Requests Drive Physician Treatment Decisions 2
(Date:10/22/2014)... Kentucky (PRWEB) October 22, 2014 Shriners ... agreement that will change the current location of Shriners ... to South Limestone across from the University of Kentucky ... a state-of-the-art ambulatory care center, owned and operated by ... the orthopaedic needs of children and their families well ...
(Date:10/22/2014)... Los Angeles, California (PRWEB) October 22, 2014 ... Recovery 2.0: Move Beyond Addiction and Upgrade Your Life (Paperback; ... the field of Yoga & Recovery. This book is ... and thrive in a life of recovery. , Recovery ... of the 12 Steps; Recovery 2.0 is a guide for ...
(Date:10/22/2014)... Pass, OR (PRWEB) October 22, 2014 ... Southern California’s fresh water supply runs dangerously low, Southern ... change. Southern Oregon’s rivers, despite the lowest mountain snow ... even in late summer and early autumn.* That was ... authors of the new book “Hiking Southern Oregon,” during ...
(Date:10/22/2014)... Healthcare professionals who are looking ... at home or on-the-go via laptops, tablets or ... new, premium Seminar-on-Demand CE courses. The new courses ... 2,000 hours of CE course offerings, allowing ... With such a diverse library, there’s something for ...
(Date:10/22/2014)... 2014 Although there are only 24 hours in ... people who have trouble finding time within their busy schedules for ... long periods of time to get in shape. Here are five ... the go. , Change Up Your Commute , Consider riding ... add some exercise into your daily routine. If you must use ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2
... is witness to an International Aids Candlelight Memorial which is ... very much a domestic problem and disassociating from it is ... estimated that nearly 2700 New Zealanders are suffering HIV. The ... people who had died of AIDS. But this time, it ...
... among women. Statistics reveals that about 290,000 women die worldwide ... were keen on finding a cure// or methods to prevent ... vaccine with the potential to cut down worldwide deaths occurring ... is mainly caused by a virus called Human Papillomavirus (HPV). ...
... rising problem of childhood obesity health officials will weigh primary ... if there is a danger that the kids are obese. ... decided to overrule the Children's Commissioner and their own child ... would affect the children's mental health. ,Caroline Flint, ...
... of engineers, accountants, lawyers joined the protesting medical students ... march started// at Maulana Azad Medical College and ended ... surprisingly peaceful rally with no sloganeering. The participants also ... disturb the normal traffic. “We do not want to ...
... artist Sudarsan Patnaik used the sands of tsunami-hit Pondicherry beach ... // . ,'Mother and Child' - spreading the ... A. Anbarasu. He unveiled the sculpture with two polio ... Polio campaign that ends on Sunday. ,Thousands of ...
... In a first ever study conducted, researchers highlight that ... a way that the facial nerve is not injured//. ... is also present, attempts to describe where and how ... bony, covering. This can provide surgeons with adequate knowledge, ...
Cached Medicine News:Health News:Study Offers Hope In Prevention Of Facial Paralysis 2
... Finntip Filters are ... other amplification methods, or ... aerosol contamination might occur. ... pipetting DNA/RNA solutions, infectious ...
1000 L, Racked, Pre-sterilized, 100 tips/rack Recommended for 500 and 1000 L pipettes....
... are ideal for PCR and ... any work where aerosol contamination ... for pipetting DNA/RNA solutions, infectious ... For applications requiring absolute sterility, ...
... Filters are ideal for PCR ... for any work where aerosol ... designed for pipetting DNA/RNA solutions, ... other. For applications requiring absolute ...
Medicine Products: