Navigation Links
Syndax Pharmaceuticals' Entinostat Shows Clinical Promise in Patients with Advanced Hormone Refractory Breast Cancer
Date:6/4/2010

WALTHAM, Mass., June 4 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, reported final results from the Phase 2, open-label ENCORE 303 trial in post-menopausal women with advanced, estrogen receptor (ER) positive breast cancer who were progressing on aromatase inhibitor (AI) therapy. Safety and efficacy results from the trial will be presented in a poster at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago, IL tomorrow, Saturday, June 5, 2010.

"These findings are significant given that the patients enrolled were heavily hormonally pre-treated and relatively hormone resistant," said Joanna Horobin, president and chief executive officer of Syndax. "Resistance to AI therapy is multi-factorial and involves up-regulation of growth factor signaling pathways and down-regulation of estrogen receptor expression which may result from epigenetic modifications to the DNA and associated proteins. The disease stabilization achieved with the addition of entinostat supports our hypothesis that entinostat has the ability to normalize gene expression, thereby restoring sensitivity to targeted agents. We are optimistic that our ongoing ENCORE 301 study, a double-blind, randomized, placebo-controlled phase 2 study of entinostat in combination with the aromatase inhibitor exemestane, will provide further evidence supporting the clinical benefit and tolerability of entinostat in combination with aromatase inhibitors."

The primary endpoint of the study was Clinical Benefit Rate (CBR), defined as the proportion of patients who experience a complete or partial response or stable disease (SD) during the first six cycles of study treatment. Of the 26 evaluable patients in the ENCORE 303 stu
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Jiangbo Pharmaceuticals, Inc. Receives Approval to List on the NASDAQ Global Market
2. Cumberland Pharmaceuticals to Present at the Wells Fargo Healthcare Conference in Boston on June 23, 2010
3. Alexza Pharmaceuticals to Present at Jefferies 2010 Global Life Sciences Conference
4. Hospira Announces Further Extension of Tender Offer for Shares of Javelin Pharmaceuticals
5. Oramed Pharmaceuticals Forms Joint Venture - Launches Entera Bio Ltd.
6. Jazz Pharmaceuticals to Present at the Jefferies 2010 Global Life Sciences Conference
7. Amylin Pharmaceuticals Appoints Christian Weyer, MD Senior Vice President, Research and Development
8. Shire Receives LIALDA(R) Paragraph IV Notice Letter From Zydus Pharmaceuticals
9. China Yongxin Pharmaceuticals Announces 1-for-12 Reverse Stock Split
10. ISTA Pharmaceuticals to Present at the Jefferies 2010 Global Life Sciences Conference
11. Isis Pharmaceuticals to Present a General Corporate Update at Its 2010 Annual Meeting of Stockholders and Open House
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... 1, 2015  Legendary actor and director Danny ... PBAFacts campaign designed to educate and encourage patients with ... Pseudobulbar Affect (PBA) and to speak with their physician. ... has the ability to cry and laugh on cue ... experienced by people living with PBA episodes. ...
(Date:5/1/2015)... , May 1, 2015 Semler Scientific, Inc. ... company that develops, manufactures and markets products that assist ... today reported financial results for the first quarter ended ... quarter of 2015, Semler reported continued progress with year ... quarter revenue growth of 14%," said Doug Murphy-Chutorian ...
(Date:5/1/2015)... Cambrex Corporation (NYSE: CBM ) reports results for the ... , Sales increased 18% compared to the first ... driven by Innovator products and Controlled Substances. , EBITDA ... quarter of 2014. , GAAP Diluted EPS from continuing ... year and Adjusted Diluted EPS was $0.29 compared to $0.07 ...
Breaking Medicine Technology:Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 2Danny Glover Joins PBA Facts Campaign, to Educate and Build Awareness of Pseudobulbar Affect (PBA), a Little Known but Widespread Neurologic Condition 3Semler Reports First Quarter 2015 Financial Results 2Semler Reports First Quarter 2015 Financial Results 3Semler Reports First Quarter 2015 Financial Results 4Semler Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 2Cambrex Reports First Quarter 2015 Financial Results 3Cambrex Reports First Quarter 2015 Financial Results 4Cambrex Reports First Quarter 2015 Financial Results 5Cambrex Reports First Quarter 2015 Financial Results 6Cambrex Reports First Quarter 2015 Financial Results 7Cambrex Reports First Quarter 2015 Financial Results 8Cambrex Reports First Quarter 2015 Financial Results 9Cambrex Reports First Quarter 2015 Financial Results 10Cambrex Reports First Quarter 2015 Financial Results 11
(Date:5/2/2015)... (PRWEB) May 03, 2015 As one ... of the prestigious Safety and Health Achievement and Recognition ... honored to be chosen by the Illinois Department of ... has achieved and maintained SHARP certification by the Occupational ... 2006, as Essentra has continued to meet or exceed ...
(Date:5/2/2015)... 2015 Vancouver fencing company, QS Fencing, has ... advice to prospective clients related to their questions on railings ... railings around their decks and patios. While that seems like ... up once the person rolls up their sleeve to start ... railing in finding a gate that matches it. , Instead ...
(Date:5/2/2015)... Viejo, CA (PRWEB) May 02, 2015 ProText ... exclusively for use in Final Cut Pro X. ProText ... for use in Final Cut Pro X . ... single keyframe with Pixel Film Studios' ProText Kinetic 2. , ... Start by staggering two ProText Kinetic presets in the ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 We are ... The Delray Recovery Center as one of the Top ... known in the addiction treatment field for their ethics ... to innovate and to continue their educational efforts. The ... workplace environment, never forgetting their purpose – to help ...
(Date:5/2/2015)... 2015 On Tuesday April 7th, the ... gathered to celebrate improvements in patient care. In 2014 ... (RVHP), had zero acquired ventilator associated infections, zero central ... ELCH was also recently named a Top Performer by ... ELCH credited the teamwork of staff from all departments ...
Breaking Medicine News(10 mins):Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2
... ... FAB-HOMES ™, a green home design studio based in Vancouver, Canada, is ... market. Fab-homes™ showcases a selection of modern, European dwellings planned along the ... 90% less energy for heating, cooling and building operation than a standard ...
... Dedicated ... ... mHealth Alliance today announced that it and the GSM Association will deliver a day-long ... the 2010 GSMA Mobile World Congress. A series of high-level presentations and seminar ...
... , The American Red Cross ... PHILADELPHIA , Feb. 11 Wednesday,s blizzard-like conditions ... Penn-Jersey Region.  The American Red Cross expected to see 1,300 ... drives were cancelled. , (Logo:   http://www.newscom.com/cgi-bin/prnh/20081216/DC52619LOGO  ) ...
... , ... make a $10 donation , WASHINGTON , ... phone users have made $10 donations to the American Red Cross ... 90999, raising a record-shattering $32 million in mobile giving for the ...
... MIAMI , Feb. 11 When the last school ... be putting down their pencils and papers in favor of video ... a price. That,s because children may be picking up something a ... the waistline. With a summertime stash of Explorer,s Bounty,s Gallop-A-Loozas line ...
... ... health care costs and improved health , ... Washington and San Francisco, CA (Vocus) February 11, 2010 -- The Integrated ... Lafarge North America Inc. with the IBI/NBCH Healthy Workforce Productivity Award at their ...
Cached Medicine News:Health News:FAB-HOMES™ Presents First Passive House Collection 2Health News:FAB-HOMES™ Presents First Passive House Collection 3Health News:mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress 2Health News:mHealth Alliance Works in Partnership with GSMA to Expand Discussion of Mobile Health at 2010 Mobile World Congress 3Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 2Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 3Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 2Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 3Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 4Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 5Health News:Red Cross Raises More Than $32 Million Via Mobile Giving Program 6Health News:Explorer's Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity 2Health News:Lafarge North America Recognized by IBI and NBCH for Health & Productivity Leadership 2Health News:Lafarge North America Recognized by IBI and NBCH for Health & Productivity Leadership 3
... Home Defibrillatorthe latest in essential safety ... deployed, Philips is the worldwide market ... and in airports, workplaces, communities, and ... is the first and only home ...
... Cadwell's custom bars have a large ... machined contacts (spaced 3 centimeters center-to-center) ... of repeated cleaning. Polarity indicators are ... snap-on handle fits our bar electrode ...
... custom bars have a large body ... contacts (spaced 3 centimeters center-to-center) to ... repeated cleaning. Polarity indicators are molded ... handle fits our bar electrode styles. ...
... The STAAR Collamer ICL and the ... lenses. Made of Collamer, STAARs proprietary collagen ... in the ciliary sulcus. This unique material ... provides excellent biocompatibility and superior optical capability. ...
Medicine Products: