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Syndax Pharmaceuticals' Entinostat Plus Erlotinib Improves Survival in Select NSCLC Patients
Date:12/9/2010

ell Lung Cancer Patients With Differential Sensitivity To Histone Deacetylase Inhibitor (hdaci) / Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (egfr-tki) Treatment" was accepted as a late-breaker and will be given as an oral presentation at a scientific session at 2:15 p.m. on Friday, December 10, 2010.

For more Information regarding the presentation please visit http://www.thoracicsymposium.org/.

About Non-Small Cell Lung Cancer (NSCLC) Non-small cell lung cancer, a disease in which malignant cells form in the tissues of the lungs, is the most common type of lung cancer. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Each year there are more than 200,000 cases of newly diagnosed advanced NSCLC. About 60% of patients present with advanced NSCLC, meaning it has spread beyond the lung, when they are seen by a doctor. The five-year survival rate is less than 10 percent for patients with advanced NSCLC.

About Entinostat Entinostat is an orally bioavailable, highly selective, class I histone deacetylase (HDAC) inhibitor with a long half-life that allows for weekly or every-other-week dosing. In addition to ENCORE 401, entinostat is being studied in numerous phase 2 clinical trials including a trial in advanced breast cancer patients in combination with aromatase inhibitors and in a Hodgkin's lymphoma trial as a single agent. Under a Cooperative Research and Development Agreement (CRADA) with the NCI, Entinostat also is being studied in multiple types of solid tumors and hematologic cancers.

Research has shown that HDACs are involved in the expression of various genes that regulate cell growth, differentiation and apoptosis. Such genes are frequently silenced in cancer cells through the over-expression of enzymes including HDACs. HDACs are therefore recognized as promising targets for cancer treatmen
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SOURCE Syndax Pharmaceuticals, Inc.
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