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Syndax Pharmaceuticals' Entinostat Plus Erlotinib Improves Survival in Select NSCLC Patients
Date:12/9/2010

WALTHAM, Mass., Dec. 9, 2010 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, announces clinical results from ENCORE 401, a double-blind, placebo-controlled phase 2 trial, in patients with advanced non-small cell lung cancer (NSCLC). The results show that there was a survival advantage in the subset of patients with elevated E-cadherin (a molecular marker of epithelial tumors) receiving entinostat in combination with erlotinib (Tarceva®).

"The data suggest that NSCLC patients with elevated E-cadherin do better when treated with entinostat and erlotinib than erlotinib alone," said principal investigator Robert M. Jotte, M.D., Ph.D., director of thoracic oncology at Rocky Mountain Cancer Center Midtown Division in Denver and Developmental Co-Chair of US Oncology Lung Committee. "In the patients with elevated E-cadherin, the median survival was 9.4 months in those treated with erlotinib plus entinostat compared to 5.4 months in the patients treated with erlotinib plus placebo. Since patients with elevated E-cadherin represent approximately 40 percent of the overall non-small cell lung cancer population, this potentially is an important new treatment option that could improve outcomes for patients with NSCLC."

Results from ENCORE 401 will be presented tomorrow, Friday, December 10, 2010, in an oral presentation at the ASTRO 2010 Chicago Multidisciplinary Symposium in Thoracic Oncology. This symposium is co-sponsored by the American Society for Radiation Oncology (ASTRO), the American Society of Clinical Oncology (ASCO), the International Association for the Study of Lung Cancer (IASLC) and The University of Chicago.

"Using a biomarker to select patients based on the tumor biology can improve patient outcomes versus treating an unselected patient population," said Fred Hirsch, M.D., Ph.D., professor of medicine and pathology at the University of Colorado Health Sciences Center. "Restoring E-cadhe
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SOURCE Syndax Pharmaceuticals, Inc.
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