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Syndax Pharmaceuticals Announces Publication of Clinical Study Demonstrating that Entinostat Targets Resistance Pathways in Breast Cancer
Date:5/14/2013

east cancer, which has spread to other parts of the body. About 70 percent of women with breast cancer have estrogen receptor-positive (ER+) breast cancer. For most of these patients, blocking estrogen activity with aromatase inhibitors represents an effective treatment. However, some women's cancers may develop a resistance to aromatase inhibitors, leading to further disease progression requiring more toxic, less effective chemotherapies.

Delaying drug resistance and disease progression represents a significant unmet need, which if addressed could prolong survival, while decreasing the substantial health care costs associated with chemotherapy and hospitalization. Prior studies have shown that resistance to aromatase inhibitors develops due to increased activity in growth factor signaling pathways, and decreased levels of estrogen receptor-alpha (ERa). Entinostat effectively decreases growth factor signaling in breast cancer cells where these pathways are active, and increases the estrogen receptor expression in breast cancer cells that might have negligible or undetectable levels of ERa.

Entinostat's proven ability to target multiple mechanisms of resistance establishes it as a promising candidate for preventing and overcoming aromatase inhibitor resistance through epigenetic modulation. In pre-clinical testing entinostat induced tumor regression when combined with an aromatase inhibitor after the development of hormone resistance, supported by a subsequent phase 2 trial ENCORE 303 in metastatic ER+ breast cancer patients progressing on treatment with aromatase inhibitors. Additional research is currently underway, in collaboration with the National Cancer Institute, to evaluate entinostat in triple-negative breast cancer.

About Syndax Pharmaceuticals
Syndax is a late-stage oncology company initiating pivotal programs in solid tumors based on employing epigenetic strategies to overcome the problem of resistance in oncology care. Syndax ho
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SOURCE Syndax Pharmaceuticals, Inc.
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