Navigation Links
Syndax Pharmaceuticals Announces Publication of Clinical Study Demonstrating that Entinostat Targets Resistance Pathways in Breast Cancer
Date:5/14/2013

for evaluation of protein lysine acetylation as a biomarker of entinostat activity.

Based on intent-to-treat analysis, patients treated with entinostat saw improved median PFS to 4.3 months, versus 2.3 months in patients treated with placebo (hazard ratio 0.73; 95% confidence interval, 0.50 to 1.07; one-sided P = .055; two-sided P = .11). Overall survival was an exploratory endpoint, and median survival improved to 28.1 months in entinostat-treated patients versus 19.8 months in placebo-treated (hazard ratio 0.59; 95% confidence interval, 0.36 to 0.97; P = .036). Fatigue and neutropenia were the most frequent grade 3/4 toxicities; treatment discontinuation because of adverse events was higher in the entinostat group versus the placebo group (11 percent versus 2 percent). Protein lysine hyperacetylation in the entinostat-treated biomarker subset was associated with prolonged progression-free survival.

"Given the need for well tolerated therapies that extend the benefit of hormone therapy in postmenopausal women with breast cancer, our ENCORE 301 study supports the evaluation of entinostat not just in breast cancer, but also in other solid tumors," said Arlene M. Morris , Syndax's chief executive officer.  "We are actively working to move entinostat into a confirmatory pivotal study this fall."

In addition to the breast cancer study publication Syndax just announced a license deal to commercialize a first-in-class lung cancer treatment strategy with entinostat in combination with erlotinib developed by the University of Colorado and based on results published in Journal of Clinical Oncology in 2012.  Click here to see the release. 

About Entinostat for Breast Cancer
Each year, approximately 207,000 women in the United States have breast cancer; 20,000 of these women have metastatic br
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
2. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
3. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
4. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
5. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
6. Icahn Issues Statement Regarding Amylin Pharmaceuticals
7. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
8. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
9. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
10. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
11. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)... Tenn. , Dec. 22, 2014   TRU-D ... automated, no-touch UV disinfection robot, announced today that the ... Schedule contract through November 2019.   This ... rapidly engage all levels of government purchasers, including Department ... as well as Homeland Security contacts purchasing solutions for ...
(Date:12/22/2014)... Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... treatment and management of epilepsy, today announced it will participate ... on Wednesday, January 14, 2015, in San Francisco ... and Chief Executive Officer, will speak at 11:00 AM Pacific ... accessed by clicking on the Investor Relations link on the ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... Reportlinker.com announces that a new ... its catalogue: United ... to 2017- Glucose Monitoring and Insulin ... United States Diabetes ...
... ReportsnReports adds new market research ... , to its store. This report examines Argentina, ... their attractiveness as pharmaceutical markets and outsourcing destinations. ... are examined. The report presents results of a ...
Cached Medicine Technology:United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 2United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 3United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 4United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 5United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 6United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 7United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 8United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 9United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 10United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 11United States Diabetes Care Devices Market Outlook to 2017- Glucose Monitoring and Insulin Delivery 12Latin America Emerging Pharmaceutical Markets - Argentina, Chile, Colombia, Peru, and Venezuela 2Latin America Emerging Pharmaceutical Markets - Argentina, Chile, Colombia, Peru, and Venezuela 3
(Date:12/26/2014)... It is said that nothing makes a lady ... famous wedding dress supplier, shows its new selection of ... promotion. , UWDress.com’s navy cocktail gowns are the cornerstones ... high fashion styles. Simple dresses in bright neon colors can ... are specially designed for those who want to shine among ...
(Date:12/26/2014)... Plugin and template developers from Pixel Film Studios ... Cut Pro X. , “TransPack Volume 5 gives users the ... an industry professional look” Said Christina Austin, CEO of Pixel ... 5, a new level of professionalism will become the standard.” ... Final Cut Pro X transitions featuring organic animations. Choose from ...
(Date:12/26/2014)... 2014 DW-InductionHeating.com (DaWei Induction Heating Co.) ... and developing, producing and marketing of a series of ... announces their new series of induction brazing equipments ... company, induction brazing refers to the joining ... material and heat. The manager says that there are ...
(Date:12/25/2014)... 26, 2014 The click ... beauty, strength and durability. Today, the business announces ... is valid until Jan. 30, 2015. , Click ... traditional hardwood. BambooFlooringChina.com is a well-known brand in ... worldwide to find a reliable bamboo flooring supplier. ...
(Date:12/25/2014)... December 26, 2014 “Every three months the ... changes. A-line sweetheart evening dress will be one of the ... manager of Yunx.co.uk says. Today, the company releases 26 A-line ... up to 80% off. , “We are trying our ... style with our latest designs. Along with affordable prices, we ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2
... Rosengart Offers Lifesaving Tips in the Fight ... Against Heart ... from,the Center for Disease Control indicates that deaths resulting from,coronary heart ... obesity, high blood pressure and high cholesterol remain on,the rise. Vitals.com, ...
... This release is also available in German . ... couples who are childless against their will. The microscopic procedure ... injection). This was discovered by scientists at the University of ... a study of 124 women. Up to now, the desire ...
... multi-institutional study comparing the accuracy of positron emission tomography ... lung nodules found that PET was far more reliable ... , CT and PET have been widely used to ... said James W. Fletcher, professor of radiology at Indiana ...
... the Bill & Melinda Gates Foundation to ... expand services in 11 new countries, OAK BROOK, Ill., ... organizations, today,announced it has received a $24.2 million grant from ... International,s,subsidiary, the Micro Insurance Agency, greatly expand its insurance,products to ...
... sponsored by CVS/pharmacy, provides free roadside assistance ... in 9 major markets -, WOONSOCKET, ... the road with a flat tire, a dead battery, or other vehicular,emergency, you ... the last 30 years, the CVS Samaritan Van program has,provided that help and ...
... depression and are more likely to remain depressed than older ... Medicine researchers in the February Archives of General Psychiatry. ... likely to die while depressed than older men, indicating that ... with the higher likelihood of women becoming depressed and remaining ...
Cached Medicine News:Health News:Vitals.com 'Goes Red' for American Heart Month 2Health News:Vitals.com 'Goes Red' for American Heart Month 3Health News:Significantly higher success rates with artificial insemination 2Health News:PET outperforms CT in characterization of lung nodules 2Health News:Opportunity International's Micro Insurance Agency to Develop and Provide Life, Health and Crop Insurance for 21 Million Poor People 2Health News:Opportunity International's Micro Insurance Agency to Develop and Provide Life, Health and Crop Insurance for 21 Million Poor People 3Health News:Opportunity International's Micro Insurance Agency to Develop and Provide Life, Health and Crop Insurance for 21 Million Poor People 4Health News:Opportunity International's Micro Insurance Agency to Develop and Provide Life, Health and Crop Insurance for 21 Million Poor People 5Health News:CVS Samaritan Van Program Celebrates 30 Years of Helping Motorists on the Nation's Highways 2Health News:CVS Samaritan Van Program Celebrates 30 Years of Helping Motorists on the Nation's Highways 3Health News:CVS Samaritan Van Program Celebrates 30 Years of Helping Motorists on the Nation's Highways 4Health News:Older women more susceptible to depression than older men 2
... offers a set of features for handling ... design that allows staff to customize the ... Using Medical Billing's electronic encounter forms, charges ... of care when used with Practice Partner ...
... In a paperless environment, providers can code the ... directly in their PDA while away from office, ... those opting to use an Encounter Form/Superbill, data ... screens. Insurance and patient payments are posted ...
The CH 2000 Cardiac Diagnostic system is a fully featured stress testing system that can include Microvolt T-Wave Alternans (MTWA) testing capability as an add-on feature. , ,Interfaces with Tra...
The HearTwave system is the original stand-alone Microvolt T-Wave Alternans (MTWA) testing platform....
Medicine Products: