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Syndax Pharmaceuticals Announces Publication of Clinical Study Demonstrating that Entinostat Targets Resistance Pathways in Breast Cancer
Date:5/14/2013

WALTHAM, Mass., May 14, 2013 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a late-stage oncology company focused on developing novel combination epigenetic strategies to treat cancers that have become resistant to standard treatments, announced today the publication in the Journal of Clinical Oncology of positive results of a phase 2 randomized, double-blind, placebo-controlled study of the company's lead drug entinostat.  The study showed that entinostat extended both progression-free survival and overall survival when added to exemestane in postmenopausal women with estrogen receptor-positive (ER+) breast cancer whose cancer had progressed after treatment with a nonsteroidal aromatase inhibitor.  

"These remarkable results show that adding entinostat, a class I histone deacetylase inhibitor (HDAC) to standard antiestrogen therapy may be an effective, well tolerated approach to targeting resistance pathways in breast cancer, particularly in hormone-positive disease," said lead author Denise A. Yardley , M.D., Senior Investigator, Sarah Cannon Research Institute; Associate, Tennessee Oncology, PLLC. "Additionally, for the first time, we identified a potential biomarker in a subset of patients with estrogen receptor positive tumors that was associated with a greater progression-free survival, which may ultimately offer the potential for improved clinical outcomes with entinostat."

The study evaluated entinostat in 130 postmenopausal women with advanced ER+ breast cancer, progressing on a nonsteroidal aromatase inhibitor. Patients were randomly assigned to 25 mg exemestane daily plus 5 mg entinostat once per week (64 patients), or exemestane plus placebo (66 patients). The primary end point was progression-free survival (PFS); blood was also collected in a subset of patients
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SOURCE Syndax Pharmaceuticals, Inc.
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