Navigation Links
Syndax Pharmaceuticals Announces Publication of Clinical Study Demonstrating that Entinostat Targets Resistance Pathways in Breast Cancer
Date:5/14/2013

WALTHAM, Mass., May 14, 2013 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a late-stage oncology company focused on developing novel combination epigenetic strategies to treat cancers that have become resistant to standard treatments, announced today the publication in the Journal of Clinical Oncology of positive results of a phase 2 randomized, double-blind, placebo-controlled study of the company's lead drug entinostat.  The study showed that entinostat extended both progression-free survival and overall survival when added to exemestane in postmenopausal women with estrogen receptor-positive (ER+) breast cancer whose cancer had progressed after treatment with a nonsteroidal aromatase inhibitor.  

"These remarkable results show that adding entinostat, a class I histone deacetylase inhibitor (HDAC) to standard antiestrogen therapy may be an effective, well tolerated approach to targeting resistance pathways in breast cancer, particularly in hormone-positive disease," said lead author Denise A. Yardley , M.D., Senior Investigator, Sarah Cannon Research Institute; Associate, Tennessee Oncology, PLLC. "Additionally, for the first time, we identified a potential biomarker in a subset of patients with estrogen receptor positive tumors that was associated with a greater progression-free survival, which may ultimately offer the potential for improved clinical outcomes with entinostat."

The study evaluated entinostat in 130 postmenopausal women with advanced ER+ breast cancer, progressing on a nonsteroidal aromatase inhibitor. Patients were randomly assigned to 25 mg exemestane daily plus 5 mg entinostat once per week (64 patients), or exemestane plus placebo (66 patients). The primary end point was progression-free survival (PFS); blood was also collected in a subset of patients
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
2. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
3. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
4. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
5. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
6. Icahn Issues Statement Regarding Amylin Pharmaceuticals
7. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
8. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
9. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
10. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
11. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hcb7bz/pharmaceutical ) ... America (London, UK - November 16-18, 2015)" conference to their offering. ... America including Columbia, Peru , ... , Uruguay , Paraguay , ... America , Chile This seminar ...
(Date:9/2/2015)... , Sept. 2, 2015 Research ... addition of the "Medical Device Studies: Clinical ... conference to their offering. This ... are involved in gathering clinical evidence required for ... is required for all medical devices and the ...
(Date:9/2/2015)... DUBLIN , Sept. 2, 2015 ... the addition of Jain PharmaBiotech,s new report ... Technologies, Markets and Companies" to their offering. ... cell biology of the BBB have opened new ... the CNS. Several carrier or transport systems, enzymes, ...
Breaking Medicine Technology:Pharmaceutical Regulatory Affairs in Latin America Seminar - London, UK - November 16-18, 2015 2Medical Device Studies: Clinical Evidence Course - London, UK - November 10-11, 2015 2Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies Report 2015-2024 2Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies Report 2015-2024 3
... , CHICAGO, Oct. 12 Ethicon Endo-Surgery today announced ... delivers system wide compression in a novel way through ... be fully operated with one hand. The one-handed design ... Endopath® products with the addition of a wider jaw ...
... , MAARSSEN, Netherlands, Oct. 12 Held in the ... South America and P-MEC South America pharma ingredients and production ... , At just over 4,900, visitor numbers for the 150+ ... of the 2008 launch event in Rio, with a major ...
Cached Medicine Technology:Ethicon Endo-Surgery Launches New Echelon Flex(TM) Endopath(R) Stapler That Delivers Echelon(TM) Compression, Now With Natural Articulation 2Ethicon Endo-Surgery Launches New Echelon Flex(TM) Endopath(R) Stapler That Delivers Echelon(TM) Compression, Now With Natural Articulation 3Sao Paulo Hosts Strong Second Year for South American Pharma Events 2
(Date:9/3/2015)... ... September 03, 2015 , ... According to an Oncology Nurse Advisor ... may help patients with oropharyngeal cancer (oral cancer) to be successfully diagnosed and treated ... caused by HPV infections, which have a high rate of success in treatment and ...
(Date:9/3/2015)... ... September 03, 2015 , ... Atlantic ... virtual conference, “Proven Pharmacy Benefit Strategies for a Rapidly Changing Marketplace.” In this ... Scripts and Milliman, will discuss how plan sponsors are adopting bold, innovative strategies ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... efficacy endpoint data collection, cloud analytics and workflow solutions today announced the ... Lisbon, Portugal, September 22-24, 2015. The esteemed faculty of worldwide pharmaceutical and ...
(Date:9/3/2015)... ... 03, 2015 , ... A scar is an unavoidable result of incision or injury to the ... ability to heal itself. The appearance of a scar is dependent on many factors – ... skin pigmentation. ”Many scars fade to near invisibility on their own over a period of ...
(Date:9/3/2015)... ... September 03, 2015 , ... Mum n Me is pleased to announce the ... extra-large size that gives maximum protection from sun exposure, wind, bugs, and germs. The ... deliver non-slip assurance by keeping the cover securely in place. The new car seat ...
Breaking Medicine News(10 mins):Health News:LA Periodontists Discuss Study on Post-Treatment Oral Rinses Used to Test Recurrence of Oral Cancers 2Health News:LA Periodontists Discuss Study on Post-Treatment Oral Rinses Used to Test Recurrence of Oral Cancers 3Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 2Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 3Health News:Do I Have To Live With That Scar? 2Health News:Do I Have To Live With That Scar? 3Health News:Do I Have To Live With That Scar? 4Health News:Mum n Me Announces New Baby Car Seat Cover 2
... swings while walking could be an early sign of ... may help physicians apply treatments to slow further brain ... available. Parkinson,s disease is an age-related disorder involving ... by impaired movement and slow speech. "The ...
... ... communications technologies before, during and after crises , ... Washington, DC and London, UK (Vocus) December 10, ... publication today, Human Rights Day, on the use of communications technologies in humanitarian crises. ...
... 10 Centene Corporation (NYSE: CNC ) today ... at approximately 6:00 AM (Eastern Time) on Friday, January 8, ... AM (Eastern Time) to discuss the details of its guidance. ... N. Scheffel, Executive Vice President, Chief Financial Officer and Treasurer, ...
... , , , PARK CITY, Utah, Dec. 10 ... the fiscal 2009 fourth quarter and year ended September 30, 2009. ... million compared to $40.9 million for the same quarter of fiscal ... was $3.2 million, or $0.29 diluted earnings per share, compared to ...
... ... of a brand new loyalty scheme for Private Podiatrist Customers – Arthurs Club . ... (PRWEB) December 10, 2009 -- Algeos is ... Arthurs Club ., , , , ,Algeos has developed this ‘new to the UK’ loyalty ...
... of medications prescribed during a hospital visit, 44% of patients ... 96% were unable to recall the name of at least ... These findings are published today in the Journal of ... patient safety issue, with one review finding some degree of ...
Cached Medicine News:Health News:Irregular arm swing may point to Parkinson's disease 2Health News:New Report Examines the Role of Communications Technologies in Humanitarian Crises, 2Health News:New Report Examines the Role of Communications Technologies in Humanitarian Crises, 3Health News:New Report Examines the Role of Communications Technologies in Humanitarian Crises, 4Health News:Centene Corporation to Provide 2010 Financial Guidance On January 8, 2010 2Health News:Centene Corporation to Provide 2010 Financial Guidance On January 8, 2010 3Health News:Nutraceutical Reports Fiscal 2009 Year End Results 2Health News:Nutraceutical Reports Fiscal 2009 Year End Results 3Health News:Nutraceutical Reports Fiscal 2009 Year End Results 4Health News:Nutraceutical Reports Fiscal 2009 Year End Results 5Health News:Nutraceutical Reports Fiscal 2009 Year End Results 6Health News:Nutraceutical Reports Fiscal 2009 Year End Results 7Health News:Nutraceutical Reports Fiscal 2009 Year End Results 8Health News:Study highlights lack of patient knowledge regarding hospital medications 2
... to do the exams you want: ,Four probe ... the easiest water path probe in the industry, ... exactly what you need to. From full ... chamber, the P60 provides the clarity of images ...
... will find the samaritan AED easy ... medical and rescue professionals) will appreciate ... manual override, and the ECG monitoring ... AED is an exceptionally well-engineered, lightweight ...
... extraordinary combination of features make the ... multi-specialty clinical environment. The versatility and ... hardware allows you to perform a ... high-quality results., ,The ideal choice for ...
Assay for Anti-HTLV-I and Anti-HTLV-II...
Medicine Products: