Navigation Links
Syndax Pharmaceuticals Announces Entinostat Enhanced Activity of Cancer Immunotherapies in Renal and Prostate Cancer Models
Date:2/9/2012

WALTHAM, Mass., Feb. 9, 2012 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, announced that scientists at Roswell Park Cancer Institute have demonstrated that entinostat, Syndax's novel, oral small molecule inhibitor of class I histone deacetylases, has novel immunomodulatory properties that contribute to the enhanced activity of cancer immunotherapies in models of renal and prostate cancer.  The results were published in PLoS ONE in an article titled, "Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal  and Prostate Cancer Models."

"The results demonstrate a novel immunomodulatory effect of entinostat and provide a rationale for the clinical testing of entinostat to enhance cancer immunotherapy,"  said Roberto Pili, MD, professor of oncology, chief, genitourinary section and co-leader, genitourinary program, department of medicine, Roswell Park Cancer Institute.  "We are interested in testing whether entinostat could improve the benefit seen with immunotherapies in the advanced disease population where oncology treatments are limited."

The results, published in the January 23rd issue of PLOS, show that entinostat inhibits the function of T regulatory cells that are involved in suppressing the anti-tumor activity of immune based therapies. Importantly entinostat maintained the activity of the T effector cell population.

"This exciting pre-clinical data provides new information about entinostat's mechanism of action, expanding the potential for entinostat in new combinations in solid tumors," said Joanna Horobin, MD, president and chief executive officer of Syndax.  "Because of collaborations like this one with the Roswell Park Cancer Institute, we are able to continue to investigate
'/>"/>

SOURCE Syndax Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Syndax Pharmaceuticals Signs Agreement with Ventana Medical Systems, Inc. to Develop Companion Diagnostic Test for Entinostat
2. Survival Benefit With Syndax Pharmaceuticals Entinostat Maintained in Women with Advanced Breast Cancer
3. Multiple Data Presentations on Syndax Pharmaceuticals Entinostat at Upcoming Scientific Conferences
4. Pharmacodynamic Data from Syndax Pharmaceuticals ENCORE 301 Study in Advanced Breast Cancer to be Highlighted at the AACR Molecular Targets and Cancer Therapeutics Conference 2011
5. Syndax Pharmaceuticals to Present at Upcoming Fall Financial Conferences
6. Syndax Pharmaceuticals Announces Entinostat Data from Two Lung Cancer Clinical Trials at Upcoming World Lung Conference
7. Syndax Pharmaceuticals Elects Arlene Morris to Board of Directors
8. Syndax Pharmaceuticals Announces Issuance of US Patent for Entinostat
9. Syndax Pharmaceuticals Announces Entinostat Data at 102nd Annual American Association for Cancer Research Meeting
10. Syndax Announces Start of NCI Sponsored Phase 2 Study of Entinostat in Combination in Triple Negative Breast Cancer
11. Syndax Announces Publication of Entinostat NSCLC Data in Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... Ariz. , July 1, 2015 Prismic ... drugs and FDA-regulated medical foods, today announced the election ... A. Simonetti to its Board of Directors. ... Board members, Peter Moriarty , Chairman and CEO ... Krivulka and Martin Simonetti have accepted ...
(Date:7/1/2015)... , July 1, 2015  Imprimis Pharmaceuticals, ... focused on the development and commercialization of proprietary ... will ring The Nasdaq stock market closing bell ... the growing success of its Go Dropless™ campaign ... million cataract procedures are performed annually in the ...
(Date:7/1/2015)... GAITHERSBURG, Md. , July 1, 2015 ... live biotherapeutics and probiotic treatments, announced today that it ... Canada Natural and Non-prescription Health Products Directorate (NNHPD) to ... Visbiome was developed by Professor Claudio ... subject of extensive clinical investigation. Professor De Simone recently ...
Breaking Medicine Technology:Joseph Krivulka and Martin Simonetti Join Board of Prismic Pharmaceuticals 2Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 2Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 3Imprimis Pharmaceuticals to Ring The Nasdaq Stock Market Closing Bell 4ExeGi Pharma Secures Canadian Approval For Well Studied Probiotic 2ExeGi Pharma Secures Canadian Approval For Well Studied Probiotic 3
... , , , INDIANAPOLIS, Dec. 9 ... leading provider of managed voice, Internet and data networking solutions ... that Indiana Blood Center has selected the company to provide ... 11 locations located throughout Indiana. Indiana Blood Center will also ...
... , , ... HBP; OTCQX: HXBPF) reports that at its Annual General Meeting ... Board of Directors , All seven Board members were ... of: , ,Donald H. Segal, Chairman of the Board and ...
Cached Medicine Technology:Indiana Blood Center Taps tw telecom for Data, Internet and IP Telephony Services 2Helix BioPharma Reports On 2009 Annual General Meeting 2Helix BioPharma Reports On 2009 Annual General Meeting 3
(Date:7/1/2015)... ... ... Camp wasn’t always a steadfast supporter of plastic surgery. But just as her career ... a terrible car accident years ago left her injured and in need of reconstructive ... What if I Do?): Answers to All Your Questions about Plastic Surgery” (published by Archway ...
(Date:7/1/2015)... PA (PRWEB) , ... July 01, 2015 , ... Who ... meaning and purpose in life with a healthy balance between work and life, and ... this in her new book, Positive Health: Flourishing Lives, Wellbeing in Doctors. , With ...
(Date:7/1/2015)... McLean, Va. (PRWEB) , ... July 01, 2015 , ... ... PRF in partnership with PAPRS, welcomed Scott Stossel, editor of The Atlantic, as a ... his personal experience combatting anxiety, and how telling his personal story added power and ...
(Date:7/1/2015)... ... July 01, 2015 , ... The Thule Atmos X4 offers ... tested to ensure it lived up to Thule’s rigorous standards. Due to its Bi-ComponentArmor ... quality Thule owners have come to expect. , The Thule Atmos X4 ...
(Date:7/1/2015)... Wis. (PRWEB) , ... July 01, 2015 , ... ... identification (RFID) safety and security solutions, has partnered with WIU Crossroads School in ... Duress Solution. The unique AEDY (Alternative Education for Disruptive Youth) environment of Crossroads ...
Breaking Medicine News(10 mins):Health News:Francesca Camp’s New Book Unmasks Plastic Surgery Advice 2Health News:Medical Doctor Explains The Healthy Effects of a Positive Outlook in New Book 2Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 2Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 3Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 4Health News:Scott Stossel, Editor of The Atlantic, Addressed Mental Health Professionals on Reducing Prejudice and Discrimination 5Health News:WIU Crossroads School Chooses Help Alert Mobile Staff Duress Pendants from RF Technologies to Safeguard Staff and Students, De-escalate Altercations 2Health News:WIU Crossroads School Chooses Help Alert Mobile Staff Duress Pendants from RF Technologies to Safeguard Staff and Students, De-escalate Altercations 3
... Activity level drops among women at certain times of year, ... changes can interfere with people,s attempts to get regular exercise, ... more in the summer and less in the winter. ... levels were monitored for 18 months. Based on pedometer readings, ...
... grant to impact underserved communities around the world , ... ... uncertain economy, Illinois College of Optometry (ICO) students are ... humanitarian missions through Student Volunteers in Optometric Service to Humanity (SVOSH). ...
... 13 /PRNewswire-FirstCall/ - Hard to Treat Diseases, Inc. (HTDS) ... a health care UK based company that has developed ... European countries, and already has the FDA approval (or ... food grade ingredients that are FDA approved. , HTDS ...
... Feb. 13 American Network, Inc., announced today that ... services for the Deaf and Hard of Hearing communities. ... and a great success as it forays into TRS ... Deaf and Hard of Hearing.PhoneCaption,s service uses innovative, patent-pending ...
... have been indicted in connection with an alleged $10 ... a Miami clinic that purported to specialize in treating ... of the Criminal Division and U.S. Attorney R. Alexander ... del Cueto, M.D., 65, Roberto Rodriguez, M.D., 54, Carlos ...
... With Threats of Closures, LayoffsLOUISVILLE, Ky., Feb. 13 ... than 3,000 health care workers at nine Appalachian ... and southern West Virginia today called on the ... to discuss recent cost-cutting proposals that will adversely ...
Cached Medicine News:Health News:Winter's Cold, Summer's Heat Take a Toll 2Health News:Cash-strapped Optometry Students Give Back in a Big Way 2Health News:Cash-strapped Optometry Students Give Back in a Big Way 3Health News:Cash-strapped Optometry Students Give Back in a Big Way 4Health News:Hard To Treat Diseases (HTDS) Negotiating to Merge with a UK Health Care Company 2Health News:PhoneCaption Provides Free Captioning Services for Deaf and Hard of Hearing 2Health News:Three Miami Physicians and Three Medical Workers Charged With $10 Million Medicare Fraud Scheme 2Health News:Health Care Workers Call on ARH Board Members to Meet, Develop Real Strategy to Deal With Hospitals' Bottom Line 2Health News:Health Care Workers Call on ARH Board Members to Meet, Develop Real Strategy to Deal With Hospitals' Bottom Line 3
... Simplex™ P with Tobramycin ... Bone Cement formula, with the ... By maintaining the original formula, ... performance characteristics of Simplex™ P ...
... Flow Analyzer is a fast, clinically proven ... of low and normal-tension glaucoma., ,The Ocular ... clinically proven measurement that improves detection of ... management of glaucoma, and detection of other ...
... Flexible Dosposable Easy Insertion/Removal ... (CSS) provides absolutely reliable support to ... thereby permitting routine phacoemulsification regardless of ... easy (similar to disposable iris retractors), ...
The collagen intracanicular plugs have a smooth proprietary finish that simplifies insertion of the plug. Collagen plugs are ideal for short term, diagnostic and post-surgical occlusion. Plugs are 2m...
Medicine Products: