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Syndax Pharmaceuticals Announces Entinostat Data from Two Lung Cancer Clinical Trials at Upcoming World Lung Conference
Date:6/27/2011

nts with advanced NSCLC and elevated levels of tumor e-cadherin at the time of initial diagnosis seemed to do better when treated with erlotinib and entinostat than those treated with erlotinib alone," said Fred R. Hirsch, M.D., Ph.D., Professor of Medicine and Pathology, University of Colorado Health Sciences Center.  "Increasingly we are seeing the importance of biomarkers in predicting patient outcomes in lung cancer.  Patients with tumors with elevated e-cadherin levels represent about 40 percent of the population, demonstrating e-cadherin is a potentially relevant clinical biomarker to select patients for treatment with erlotinib plus entinostat."The following poster and oral presentation on the entinostat and erlotinib combination will be presented Wednesday, July 6 at the World Conference on Lung Cancer:Title:

Analysis of cross-over portion of ENCORE-401, a randomized, double-blind, placebo-controlled phase 2 study of erlotinib with and without entinostat, a class 1 isoform selective histone deacetylase inhibitor (HDAC) in patients with advanced non-small cell lung cancerTime:

12:15 PM – 2:15 PMSession info:

P3.220 Room:

Exhibition HallTitle:

Biomarker analysis of a randomized, double-blind, placebo-controlled phase 2 study of erlotinib with and without entinostat, a class 1 isoform selective histone deacetylase inhibitor (HDAC) in patients with advanced non-small cell lung cancer (NSCLC; ENCORE-401)Time:

2:30 PM - 4:00 PM*Session info:

Mini Oral Session, MO15.04 Room:

G104* This presentation also will be the subject of an e-poster on the same day from 12:15 to 2:15.  Entinostat and 5-Azacitidine (Vidaza®) Syndax and the National Cancer Institute (NCI) are using a dual epigenetic therapy approach to treating advanced lung cancer.   It has been shown that epigenetic gene silencing mediated by DNA methylation and histone deaceylation is a key contr
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SOURCE Syndax Pharmaceuticals, Inc.
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