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Syndax Pharmaceuticals Announces Entinostat Data from Two Lung Cancer Clinical Trials at Upcoming World Lung Conference
Date:6/27/2011

WALTHAM, Mass., June 27, 2011 /PRNewswire/ -- Syndax Pharmaceuticals, Inc., a clinical-stage epigenetics oncology company, today announced that data from two entinostat clinical trials both based on tumor reprogramming will be presented at the International Association for the Study of Lung Cancer's (IASLC) 14th World Conference on Lung Cancer meeting (www.2011worldlungcancer.org) July 3 to 7 in Amsterdam, The Netherlands.  

"The data presentations from both lung cancer programs at the World Conference on Lung Cancer demonstrate the clinical progress we are making with entinostat as we advance toward phase three,"  said Joanna Horobin, president and chief executive officer of Syndax.  "The results add to the growing body of evidence that entinostat can maintain and restore sensitivity to standard of care treatments in distinct subpopulations of patients.  Having completed placebo-controlled phase 2 clinical trials in both lung and breast cancer, we are actively planning the final stage of development."

Entinostat and Erlotinib (Tarceva®)Targeted therapies such as epidermal growth factor receptor inhibitors (EGFRi) have greatly improved the treatment of those non small cell lung cancer (NSCLC) patients that harbor the appropriate targets. However, other patients experience less benefit due in part to epigenetic changes in the tumor which reduce the sensitivity to EGFRi such as erlotinib.  Entinostat has been shown to delay the emergence of erlotinib resistance by maintaining a sensitive tumor phenotype.(1)  In other preclinical studies entinostat was shown to synergize with certain EGFRi's to enhance gene re-expression and inhibit cancer cell growth.(2)  ENCORE-401, a double-blind, placebo-controlled phase 2 trial of erlotinib with and without entinostat in patients with advanced  NSCLC was conducted to confirm the preclinical findings.

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SOURCE Syndax Pharmaceuticals, Inc.
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