Navigation Links
Swedish in Seattle to Study Connections Between Preeclampsia and Migraine
Date:9/29/2008

- $2.9 million research grant awarded by NIH; Findings could benefit pregnant women worldwide

SEATTLE, Sept. 29 /PRNewswire-USNewswire/ -- The National Institute of Child Health and Human Development division of the National Institutes of Health (NIH) has awarded Michelle A. Williams, Sc.D., a $2.9 million grant for a five-year research project to examine possible linkages between the serious pregnancy complication known as preeclampsia and migraine.

Dr. Williams is a co-founder and co-director of Swedish's Center for Perinatal Studies and one of the world's leading authorities on preeclampsia and other pregnancy concerns. She is also a professor of Epidemiology at the University of Washington.

The research project, titled "A Prospective Cohort Study of Migraines, Platelet Activation and Preeclampsia," will be conducted by Dr. Williams and her co-investigator Sheena Aurora, M.D., a migraine specialist with the Swedish Pain and Headache Center. Together they will work with experts at the Puget Sound Blood Center.

The goal of the research is to evaluate whether, and to what extent, a maternal pre-gestational history of migraines and migraine symptoms during early pregnancy are associated with the risk of preeclampsia.

Preeclampsia is a vascular disorder characterized by high blood pressure and the presence of protein in the urine starting around mid-pregnancy. It occurs in up to 8 percent of all pregnancies and, in addition to other hypertensive disorders, is the leading global cause of maternal and infant illness and death.

Migraine is a common chronic-episodic disorder characterized by severe, debilitating headaches. It is often accompanied by nausea and sensitivity to activity and/or external stimuli. Between 14 percent to 25 percent of women suffer from some form of migraine, which is more common during childbearing years.

"There have been a few reports in the medical literature of connections between preeclampsia and migraine," said Dr. Williams. "If we can confirm a definitive link and identify women at higher risk of preeclampsia early enough, then we can monitor them and intervene when necessary."

Starting this fall, Swedish will enroll approximately 2,000 women who are in their first trimester of pregnancy from obstetrics clinics affiliated with the medical center. As part of the study protocol, women who screen positive for migraine or indicate they have experienced it will have a follow-up interview with Dr. Aurora to confirm the diagnosis, and then be interviewed about their medical history. Enrolled women will be followed through to delivery and information will be collected during in-person interviews using study questionnaires.

"We'll collect blood samples during routine prenatal exams, in part, to evaluate the role of platelet aggregation and activation in preeclampsia," said Dr. Williams. "We're trying to go way beyond asking women to self-report and look at specific bio-markers in the blood."

Platelets, a key element of blood clotting, are only activated when needed. For unclear reasons, higher clotting levels have been reported in migraine sufferers and women with preeclampsia. "That suggests a connection, but we need to test that hypothesis thoroughly," Dr. Williams noted. "Only then can we develop conclusions that have medical value and can be acted on."

The research will also evaluate what prescription drugs study subjects take for migraines to determine if there are any clear connections between specific drugs and pregnancy outcomes.

"There is important public health significance to this research," said Tanya Sorensen, M.D., co-director of Swedish's Center for Perinatal Studies. "Migraine is treatable and understanding it better may help clinicians reduce the significant problems associated with preeclampsia."

Earlier this year, Dr. Williams was awarded a $495,554 grant from the March of Dimes Foundation to fund a three-year research project to identify pre-conceptional risk factors and biological markers of preeclampsia and preterm delivery in China.

About Swedish

Swedish is the largest, most comprehensive nonprofit health provider in the Greater Seattle area. It is comprised of three hospital campuses - First Hill, Cherry Hill and Ballard - a freestanding emergency department and specialty center in Issaquah, Home Care Services, and the Swedish Physician Division - a network of about 40 primary-care and specialty clinics located throughout King County. In addition to general medical and surgical care, Swedish is known as a regional referral center, providing specialized treatment in areas such as cardiovascular care, cancer care, neuroscience, orthopedics, high-risk obstetrics, pediatrics, organ transplantation and clinical research. For more information, visit http://www.swedish.org


'/>"/>
SOURCE Swedish Medical Center
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Seattles Swedish Cancer Institute First in U.S. to Treat Cancer Patient with Elekta VMAT
2. Karolinska Institute to Test Vicals Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
3. Karolinska Institutet to Test Vicals Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
4. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
5. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
6. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
7. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
8. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
9. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
10. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
11. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... MINNEAPOLIS , April 20, 2017  Cogentix ... company focused on providing the Urology, Uro/Gyn and ... reported that Ash Keswani has joined the Company ... In this newly created position, Mr. Keswani will ... and CEO. "Our organization is delighted ...
(Date:4/20/2017)... 2017  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... that it will be participating in the Deutsche Bank ... Hotel in Boston, Massachusetts on ... 11:20 a.m. Eastern Time. A live webcast ... Investor Relations website at http://investor.zimmerbiomet.com .  The webcast ...
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
Breaking Medicine Technology:
(Date:4/28/2017)... California (PRWEB) , ... April 28, 2017 , ... ... T8 Direct Replace tubes . These lamps offer an instant energy-saving solution for ... need to rewire fixtures or disconnect ballasts. These 50,000 hour rated lamps utilize ...
(Date:4/28/2017)... ... 28, 2017 , ... From April 30 to May 3, ... will host industry leaders for the annual spring Convention & Expo, called Momentum ... adapt to the issues currently affecting urgent care and on-demand healthcare. , “Momentum ...
(Date:4/28/2017)... ... 2017 , ... Researchers at Moffitt Cancer Center ... Data Hub in a sample of participants enrolled in an ongoing cancer quality-of-life ... solutions for the global scientific community. The company’s new CentrePoint Data Hub is ...
(Date:4/28/2017)... ... April 28, 2017 , ... Rob Lowe is a popular actor that has ... presence to an educational purpose as the host of the “Informed” series. The program ... a recent episode, the series focuses on thyroid cancer. , Although thyroid cancer is ...
(Date:4/27/2017)... ... 27, 2017 , ... Healthcare companies are trying to meet talent shortages and ... healthcare executive resume. , “If you’re a healthcare executive open to new opportunities this ... it’s as ready as you are for a new job search. I’ve heard from ...
Breaking Medicine News(10 mins):