Navigation Links
Sustained Viral Response from Phase 2 Studies of BI 201335, Including Difficult-to-Treat HCV Patient Types
Date:11/8/2011

s missing (n=31) achieved 100 percent and 86 percent SVR, respectively.  IL-28B is a gene that is an important predictor of the likelihood of response to HCV treatment.  Patients with non-CC alleles of IL-28B are less likely to achieve SVR with PegIFN/RBV treatment.  A previously presented analysis of SILEN-C1 showed there was no benefit of PegIFN/RBV LI dosing.

SILEN-C1 is a double-blind, randomized, placebo-controlled trial that randomized 429 treatment-naive GT1 HCV patients (1:1:2:2) to receive either placebo or BI 201335 120 mg with three days LI of PegIFN/RBV, BI 201335 240 mg once daily with three days LI or BI 201335 240 mg once daily without LI.  In each treatment group, BI 201335 was given for 24 weeks together with PegIFN/RBV for 24 or 48 weeks.  SVR results from all SILEN-C1 study groups were previously presented at the 46th Annual Meeting of the European Association for the Study of the Liver (EASL) in April 2011.

In SILEN-C1, the most frequent dose-dependent AEs in BI 201335 treatment groups were gastrointestinal disorders, rash, photosensitivity and jaundice resulting from isolated unconjugated hyperbilirubinemia.

About Hepatitis C Virus

HCV is an infectious disease of the liver and is a leading cause of chronic liver disease, transplant and failure that affects as many as 175 million people globally, with three to four million new infections occurring each year.  In the United States, an estimated 4.1 million Americans have been infected with HCV, of whom approximately 3.2 million have chronic HCV infection.  Chronic HCV infection is the cause of an estimated 8,000 to 10,000 deaths annually in the United States.  The majority – about 75 to 85 percent – of HCV cases will develop into chronic infection.  It is estimated 20 percent of patients with chronic HCV will develop cirrhosis within 20 years of infection.  The mortality rate after cirrhosi
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
2. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
3. Lotus Pharmaceuticals, Inc. Achieves Significant Milestones in the Development of Isosorbide Mononitrate Sustained Release Tablets
4. FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment
5. CERVARIX(R) Shown to Provide Longest Duration of Sustained Neutralizing Antibodies to Date
6. After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008
7. Schering-Plough Announces Phase III Data for Sustained Follicle Stimulant
8. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
9. FDA Updates Label for AVANDIA(R) to Include Clinical Findings Demonstrating Sustained Glycemic Control for Up to Five Years
10. Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients
11. Spherics, Inc. Offers Extended Release Formulation for Sustained and Stable Levodopa Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 26, 2015  CCS Medical ("CCS"), one of ... for patients with chronic conditions, has named ... Officer, effective March 23.  Mr. Carson joins CCS ... he was President of Operations. ... Executive Vice President of Operations at NationsHealth, (n/k/a ...
(Date:3/26/2015)... PLEASANTON, Calif. , March 26, 2015  Desert ... the Nation five times , is the first ... System in its emergency department to help clinicians prevent ... in Victorville, Calif. , is a ... and bariatric patients.  Using the Leaf Patient Monitor in ...
(Date:3/26/2015)... 26, 2015 Even the Score today marked ... and Drug Administration,s landmark approval of Viagra with the ... Congress calling on the Agency to begin restoring gender ... treatment for women,s most common sexual dysfunction. ... options for sexual dysfunction – while women have zero ...
Breaking Medicine Technology:CCS Medical Team Hires Industry Operator Rodney Carson as CEO 2Desert Valley Medical Center First to Use Leaf Healthcare Patient Wearable Technology in its ED as Part of Hospital-wide Deployment 2Desert Valley Medical Center First to Use Leaf Healthcare Patient Wearable Technology in its ED as Part of Hospital-wide Deployment 3Even The Score Marks 17th Viagra Anniversary with Release of New Letter from Members of Congress to FDA Calling for Equity in Sexual Health 2Even The Score Marks 17th Viagra Anniversary with Release of New Letter from Members of Congress to FDA Calling for Equity in Sexual Health 3Even The Score Marks 17th Viagra Anniversary with Release of New Letter from Members of Congress to FDA Calling for Equity in Sexual Health 4
... Center has joined managed technology cooperative Hosted Technology Exchange ... paired with major cost savings. Membership in ... in short and long-term operating and capital expenses and ... the coming years. "We have joined ...
... Reportlinker.com announces that a new market ... Global Sterilization Equipment ... http://www.reportlinker.com/p0703229/Global-Sterilization-Equipment-and-Supplies-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Machine_T This report ... and Supplies in US$ Million by the ...
Cached Medicine Technology:Hosted Technology Exchange Welcomes Akron General 2Global Sterilization Equipment and Supplies Industry 2Global Sterilization Equipment and Supplies Industry 3Global Sterilization Equipment and Supplies Industry 4Global Sterilization Equipment and Supplies Industry 5Global Sterilization Equipment and Supplies Industry 6Global Sterilization Equipment and Supplies Industry 7Global Sterilization Equipment and Supplies Industry 8Global Sterilization Equipment and Supplies Industry 9Global Sterilization Equipment and Supplies Industry 10Global Sterilization Equipment and Supplies Industry 11Global Sterilization Equipment and Supplies Industry 12Global Sterilization Equipment and Supplies Industry 13Global Sterilization Equipment and Supplies Industry 14Global Sterilization Equipment and Supplies Industry 15Global Sterilization Equipment and Supplies Industry 16Global Sterilization Equipment and Supplies Industry 17Global Sterilization Equipment and Supplies Industry 18Global Sterilization Equipment and Supplies Industry 19Global Sterilization Equipment and Supplies Industry 20Global Sterilization Equipment and Supplies Industry 21Global Sterilization Equipment and Supplies Industry 22Global Sterilization Equipment and Supplies Industry 23Global Sterilization Equipment and Supplies Industry 24Global Sterilization Equipment and Supplies Industry 25
(Date:3/26/2015)... Behavioral Research Group, LLC , a ... of BathroomMap® , a new bathroom finder app ... restrooms for travelers, especially those with medical conditions. Contrary ... facilitate a paid, social or crowdsourced model, but rather ... establishments that have clean, available restrooms in any given ...
(Date:3/26/2015)... Visiting Nurse Association of Northern ... gala fundraiser, Lighting the Way, Brightening the Day, on ... Madison Hotel in Morristown, NJ. , Guests will ... musician Rio Clemente, delightful cuisine, an extensive silent auction ... Additionally, two prestigious awards will be presented to this ...
(Date:3/26/2015)... ANNAPOLIS, Md. (PRWEB) March 26, 2015 ... more than $11.3 billion in 2014, according to ... Revista. , The Annapolis-based healthcare real estate (HRE) ... new board members and two new Gold-Level Partners: ... Estate Investment Services. , MOB transactions still going ...
(Date:3/26/2015)... 26, 2015 The Life Support ... to Hyperbaric Medicine” course, which is accredited by ... and the National Board of Diving & Hyperbaric ... course 4 times a year at several of ... tri-state region; registration is available on-line at: ...
(Date:3/26/2015)... Philadelphia, PA (PRWEB) March 26, 2015 ... to identifying brain aneurysms and preventing often fatal ... non-profit organization dedicated to raising awareness of brain ... , The issue has captured national attention with ... Colagrossi , 49, who died last Friday after ...
Breaking Medicine News(10 mins):Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 2Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 3Health News:Morristown VNA Fundraiser to Honor Distinguished Community Members 2Health News:Medical Real Estate Sales Topped $11.3 Billion in 2014 2Health News:Medical Real Estate Sales Topped $11.3 Billion in 2014 3Health News:Medical Real Estate Sales Topped $11.3 Billion in 2014 4Health News:The Life Support Technologies Group (LST) Conducted its 30th Accredited “Introduction to Hyperbaric Medicine” Course for Health Care Professionals 2Health News:The Life Support Technologies Group (LST) Conducted its 30th Accredited “Introduction to Hyperbaric Medicine” Course for Health Care Professionals 3Health News:The Life Support Technologies Group (LST) Conducted its 30th Accredited “Introduction to Hyperbaric Medicine” Course for Health Care Professionals 4Health News:Research and Funding Are Keys to Raising Awareness and Ultimately Preventing Fatal Brain Aneurysm Ruptures 2Health News:Research and Funding Are Keys to Raising Awareness and Ultimately Preventing Fatal Brain Aneurysm Ruptures 3
... , FRESH MEADOWS, N.Y., Aug. 4 ... providing conversion services and software to publishers, information aggregators, industry, ... forefront supporting the life sciences community in complying with the ... SPL is an XML standard used by the FDA ...
... , ... Alaska takes top spot for 2nd year ... Fitness and Sports today recognized Alaska, Washington, D.C., Guam, Maryland and Wyoming as winners ... in the nation based on state population, once again placed first in this year,s ...
... led to dramatic decrease in tumors , TUESDAY, Aug. ... the risk of developing breast cancer better than full-time ... Cancer Prevention Research . , Three sets of mice ... diets: unlimited eating, intermittently cutting calories by 25 percent, ...
... R.I., and WALTHAM, Mass., Aug. 4 ... Medical Innovations (NYSE: IMA ), through its Alere ... enhance the companies, ability to deliver more timely, highly coordinated ... will improve participants, health care outcomes while helping payers and ...
... , NEW YORK, Aug. 4 /PRNewswire-FirstCall / ... today that the Company and Alfa Wassermann S.p.A. have settled ... for Sulonex (sulodexide). Under the terms of the settlement agreement, ... already been received by Keryx and $750,000 is to be ...
... , INDIANAPOLIS, Aug. 4 Arcadia Resources, ... of innovative consumer health care services under the Arcadia HealthCare(SM) ... care provider Comfort Keepers((R) )to provide DailyMed(TM) for Comfort Keepers ... said the program with Comfort Keepers will launch this month ...
Cached Medicine News:Health News:Data Conversion Laboratory Supports Newest SPL Requirements For Life Sciences Industry 2Health News:President's Council Announces Top 5 Winners of 2009 National President's Challenge 2Health News:Periodic Dieting May Cut Breast Cancer Risk 2Health News:CVS Caremark and Inverness Medical Innovations Launch Strategic Alliance to Provide Enhanced Health Management Services to Clients 2Health News:CVS Caremark and Inverness Medical Innovations Launch Strategic Alliance to Provide Enhanced Health Management Services to Clients 3Health News:CVS Caremark and Inverness Medical Innovations Launch Strategic Alliance to Provide Enhanced Health Management Services to Clients 4Health News:Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann 2Health News:Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann 3Health News:Arcadia HealthCare's DailyMed(TM) Signs Deal with Comfort Keepers(R), A Leading Provider of In-Home Care 2Health News:Arcadia HealthCare's DailyMed(TM) Signs Deal with Comfort Keepers(R), A Leading Provider of In-Home Care 3Health News:Arcadia HealthCare's DailyMed(TM) Signs Deal with Comfort Keepers(R), A Leading Provider of In-Home Care 4Health News:Arcadia HealthCare's DailyMed(TM) Signs Deal with Comfort Keepers(R), A Leading Provider of In-Home Care 5
... System consists of a sterile Hemostatic ... Compression System.,Both devices work together to ... achieves topical hemostasis by facilitating clotting ... Femoral Compression System provides external compression ...
... WaveScan WaveFront System is an ophthalmic diagnostic ... wavefront aberrations of the human eye using ... be used to determine regular (sphero-cylindrical) refractive ... or blurry vision in the human eye. ...
... LADARWave® device gives you ... measure and display the ... individual eye. This capability ... a better understanding of ...
... eye drops quickly remove redness ... other pollutants and provide protection ... and the sun. This unique ... LIQUIFILM®, to soothe, cool and ...
Medicine Products: