Navigation Links
Sustained Viral Response from Phase 2 Studies of BI 201335, Including Difficult-to-Treat HCV Patient Types
Date:11/8/2011

BI 201335 on the background of 24 weeks of PegIFN/RBV was sufficient to achieve sustained viral response (SVR).  Patients with undetectable viral load prior to week 8 had similar SVR rates, whether they were treated for 12 or 24 weeks with BI 201335 (80 percent and 82 percent, respectively).

The most frequent adverse events (AEs) in SILEN-C3 were mild gastrointestinal disorders, rash, photosensitivity and jaundice due to isolated unconjugated hyperbilirubinemia.

In this open-label Phase 2 trial, 159 treatment-naive GT1 HCV patients were randomized to receive 120 mg BI 201335 once daily for 12 or 24 weeks, each after three days lead-in (LI) with PegIFN/RBV.  In both groups, PegIFN/RBV was given for 24 weeks.  Patients who did not have an eRVR continued PegIFN/RBV to week 48.  eRVR was defined as viral load less than 25 IU/mL at week 4 and undetectable at weeks 8-18.  In the 12 week treatment group, 72 percent of patients had an eRVR and in the 24 week treatment group, 82 percent of patients had an eRVR.

(Abstract #226) Treatment with the 2nd Generation HCV Protease Inhibitor BI 201335 Results in High and Consistent SVR Rates – Results from SILEN-C1 in Treatment-Naive Patients Across Different Baseline Factors

This analysis of SILEN-C1 evaluated SVR according to various baseline characteristics among patients who received BI 201335 240 mg once daily without LI.

The majority of patients with more difficult-to-treat HCV types – specifically GT1a and IL-28B non-CC allele patients – achieved SVR.  Among patients with GT1a HCV (n=32), a type that traditionally is associated with lower treatment response rates compared to GT1b, 82 percent achieved SVR.  Among GT1b HCV patients (n=38), 84 percent achieved SVR.  In addition, SVR was 71 percent for patients with non-CC alleles of the IL-28B gene (n=29).  Patients with CC alleles (n=11) or for whom IL-28B genotyping wa
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
2. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
3. Lotus Pharmaceuticals, Inc. Achieves Significant Milestones in the Development of Isosorbide Mononitrate Sustained Release Tablets
4. FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment
5. CERVARIX(R) Shown to Provide Longest Duration of Sustained Neutralizing Antibodies to Date
6. After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008
7. Schering-Plough Announces Phase III Data for Sustained Follicle Stimulant
8. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
9. FDA Updates Label for AVANDIA(R) to Include Clinical Findings Demonstrating Sustained Glycemic Control for Up to Five Years
10. Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients
11. Spherics, Inc. Offers Extended Release Formulation for Sustained and Stable Levodopa Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... -- Within just two years after reaching a milestone ... 3,000 employees worldwide. This increase is reflecting a ... delivery market and SHL,s effective commitment, productivity and ... design and manufacturing of auto injectors and pen ... a lean supply chain, strong partnerships, and more. ...
(Date:9/1/2015)... , Aug. 31, 2015 Research ... addition of the "Introduction to Veterinary Pharmacovigilance ... their offering. This course has ... good introduction to those concerned with Veterinary Pharmacovigilance. ... personnel who reqire a better understanding of veterinay ...
(Date:9/1/2015)... 2015 - The ... egistry data presented at ESC Congress ... the evolution of manag ing AF in ... -   The first-ever two-year outcomes from the Global Anticoagulant ... expose that all-cause death was the most frequent major event in more than ...
Breaking Medicine Technology:SHL Group Reaches Major Milestone of 3000 Employees 2Introduction to Veterinary Pharmacovigilance Seminar (London, UK - September 23-24) 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9
... 2012  Before purchasing electronic health records software ... management features, supported architectures and the ONC-ATCB certification ... consists of health information compiled from multiple health-oriented ... contains a patient,s medical information from one organization, ...
... Inc. (NYSE: PRX ) announced today that it will ... 2012 at 9:00 AM EST to review results for the fourth ... results on February 28, 2012 before the market opens. ... website at www.parpharm.com . Dial-in Information ...
Cached Medicine Technology:Let FindTheBest Help You Choose The Best Electronic Health Record Software 2
(Date:9/1/2015)... , ... September 01, 2015 , ... ... members of the American Society for Dermatologic Surgery, according to a new survey ... ASDS Consumer Survey on Cosmetic Dermatologic Procedures – which reflects views on cosmetic ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... Extension Vending Machine,” is still strongly maintaining her firm’s success in the hair ... tools. In her upcoming city-to-city tour, Ellis will be providing “Look and learn” ...
(Date:9/1/2015)... ... September 01, 2015 , ... The Jerry Segal Classic to benefit the patients ... Valley Country Club in Lafayette Hill, PA. Over the past 26 years, the Classic, ... programs and services designed to support patients and their families during their time at ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... announced the release of version 5.2 of the FirstSpirit Content Management System with ... initiative. With the new version of FirstSpirit, companies will be well on their ...
(Date:9/1/2015)... , ... September 01, 2015 , ... The FSH ... incurable disease, facioscapulohumeral muscular dystrophy (FSHD), will be the beneficiary of a collection of ... mission – to raise awareness of the FSH Society and further FSHD research. ...
Breaking Medicine News(10 mins):Health News:Survey: Consumers Prefer ASDS Members 2Health News:Survey: Consumers Prefer ASDS Members 3Health News:Beauty Entrepreneur creates hair extension smart machine and mobile app inspired by UBER technology 2Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 3Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 3
... The National Institutes of Health,s National Cancer Institute ... York (CCNY) and Memorial Sloan-Kettering Cancer Center (MSKCC) ... partnership in cancer research, education, and outreach. The ... program, an initiative created to develop partnerships between ...
... and teens, ages 6 to 17, who are coping with the death of ... The Bay,s 2nd annual grief support camp weekend, Camp Erin™ Oakland/Bay Area, which ... ... North Bay, San Francisco, and East Bay children and teens, ages 6 to ...
... Physicians at Northwestern Memorial Hospital successfully ... the first in the Midwest and the third in ... known as NOTESnatural orifice translumenal endoscopic surgeryis gaining in ... medical profession as laying the groundwork for truly "incisionless" ...
... Researchers at the University of Pennsylvania School of Medicine ... and gained insight into cardiovascular development, all thanks to ... Professor of Medicine, graduate student Benjamin Kleaveland, and colleagues ... that a human vascular condition called Cerebral Cavernous ...
... risk factor is metabolic syndrome has distinct forms and structures ... March issue of Hepatology , a journal published by ... for the Study of Liver Diseases (AASLD). The article is ... , Cancer of the liver, also known as hepatocellular carcinoma, ...
... Both Students and Professionals Seeking CertificationNEW YORK, ... global provider of information resources for the ... ( http://www.accessanesthesiology.com ), the first online resource ... and perioperative medicine. This innovative learning website ...
Cached Medicine News:Health News:NIH awards $15.9 million to CCNY and Memorial Sloan-Kettering to create partnership 2Health News:Apply for Free, Youth Grief Support Camp Hosted by Hospice By The Bay in August 2Health News:Apply for Free, Youth Grief Support Camp Hosted by Hospice By The Bay in August 3Health News:Gallbladder removal through vagina offers minimally invasive alternative 2Health News:Gallbladder removal through vagina offers minimally invasive alternative 3Health News: Big-hearted fish reveals genetics of cardiovascular condition 2Health News: Big-hearted fish reveals genetics of cardiovascular condition 3Health News:Liver tumors associated with metabolic syndrome differ from other tumors 2Health News:New Online, Media-Rich Educational and Clinical Resource in Anesthesiology Launched by McGraw-Hill Professional 2Health News:New Online, Media-Rich Educational and Clinical Resource in Anesthesiology Launched by McGraw-Hill Professional 3
Anterior Interbody fusion with proven clinical performance. Large hole design. Request info fda status for sale....
... images are transmitted through sorted ... picture and transmit it to ... flexoscopes are designed for rough, ... repaired at low cost if ...
The flexible endoscope was mainly developed for the pure neuroendoscopy. Due to the working channel it is ideal suitable for therapeutic indications e.g. subdural hematomas, cysts or intraventricular...
The original Zeppelin High-Speed Motordrill System has been developed to rapidly cut bone, plastic and metal with utmost precision. 120-150 psi - 90.000 rpm - 90g - autoclavable at <134 C....
Medicine Products: