Navigation Links
Survival Data in FDA Approval for ERBITUX(R) (Cetuximab) Supports use as a Single Agent in Patients with Advanced Colorectal Cancer
Date:10/2/2007

he only approved biologic therapy to demonstrate improved overall survival as a single agent in patients with metastatic colorectal cancer," said Martin Birkhofer, M.D., Vice President, Oncology Global Medical Affairs, Bristol-Myers Squibb. "We continue to be encouraged by the benefits of ERBITUX in metastatic colorectal cancer, and are actively exploring its potential in other tumor types."

About Colorectal Cancer

In the U.S., approximately 154,000 people will be diagnosed with cancer of the colon or rectum this year. More than half of these patients have metastatic disease, or cancer that has spread to other organs, at the time of diagnosis. EGFR is expressed in 60-80 percent of colorectal cancer tumors. Colorectal cancer is the third most common cancer in both men and women, excluding skin cancer.

About ERBITUX(R) (Cetuximab)

ERBITUX is a monoclonal antibody (IgG1 Mab) designed to inhibit the function of a molecular structure expressed on the surface of normal and tumor cells called the epidermal growth factor receptor (EGFR, HER1, c-ErbB-1). In vitro assays and in vivo animal studies have shown that binding of ERBITUX to the EGFR blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human tumor types. While the mechanism of ERBITUX's anti- tumor effect(s) in vivo is unknown, all of these processes may contribute to the overall therapeutic effect of ERBITUX. EGFR is part of a signaling pathway that is linked to the growth and development of many human cancers, including those of the head and neck, colon and rectum.

ERBITUX, as a single agent, is indicated for the treatment of EGFR- expressing, metastatic colorectal carcinoma (mCRC) after failure of both irinotecan-and oxalip
'/>"/>

SOURCE Bristol-Myers Squibb Company; ImClone Systems Incorporated
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Velcade (bortezomib) for Injection Based Induction Therapy Delivered High Post-Transplant Complete Remission Rate, a Critical Marker for Increased Overall Survival
2. The European Myeloma Platform Reports New Survival data for Revlimid Presented at the International Myeloma Workshop in Greece
3. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
4. Velcade (bortezomib) for Injection Based Therapies Achieved Survival Rates as High as 100 Percent in Newly Diagnosed Multiple Myeloma Patients
5. Velcade (bortezomib) for Injection Survival Data in Front-Line Multiple Myeloma Patients to be Featured at 11th International Myeloma Workshop
6. First single breast cancer study to show significant survival benefit for women switching from tamoxifen to Arimidex
7. Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Gerons Human Embryonic Stem Cell-Based Therapeutic for Heart Failure
8. Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen
9. Ivivis PEMF Technology Significantly Improves Neuron Survival in Parkinsons Disease Model, Study Finds
10. Synta Presents Results for STA-4783 in Metastatic Melanoma Showing Improvement in Overall Survival
11. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... 27, 2015 Concord Medical Services Holdings ... CCM ), a leading specialty hospital management solution ... radiotherapy and diagnostic imaging centers in ... a purchase agreement under which Concord Medical Services ... the Company, agreed to acquire the Fortis Surgical ...
(Date:3/26/2015)... , March 26, 2015  The Burzynski Research ... study independently conducted by the Department of Surgery ... Japan have been published. The study, ... hepatic arterial infusion as post-operative adjuvant therapy with ... of the liver. A total ...
(Date:3/26/2015)... March 26, 2015 Huntington Memorial Hospital is ... perform transcatheter aortic valve replacement (TAVR), a minimally invasive ... revolutionary new way to replace an aortic valve without ... lung machine. The procedure is performed by ... Azhil ( Alex) Durairaj , MD, interventional cardiologist and ...
Breaking Medicine Technology:Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2
... Mylan Inc. (Nasdaq: MYL ) today ... approval from the U.S. Food and Drug Administration (FDA) ... Acid Injection, 100 mg/mL, packaged in 1,000 mg/10 mL ... Pharmacia & Upjohn,s Cyklokapron® Injection, which is indicated for ...
... Dec. 1, 2011 /PRNewswire-iReach/ -- Global ... Pipeline Analysis, Competitive Landscape and Market Forecasts to ... (Photo:   http://photos.prnewswire.com/prnh/20111201/CG15956 ) ... deliver insulin in a precisely controlled manner at ...
Cached Medicine Technology:GiiResearch.com: Insulin Pumps - Availability of Reimbursement and Favorable Clinical Trial Data to Drive Market Growth 2GiiResearch.com: Insulin Pumps - Availability of Reimbursement and Favorable Clinical Trial Data to Drive Market Growth 3
(Date:3/28/2015)... 28, 2015 Pitching speed, player’s height, and ... shoulder and elbow injuries, according to new research released today ... ) Specialty Day. , “Our findings indicate that a 10 ... in likelihood of a history of injury, a 10 mile ... increase likelihood of a history of injury, and playing for ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Delaying rotator ... be necessary, according to research presented today at the ... Specialty Day. , “Our study compared results for 170 ... underwent an additional glenohumeral joint capsule release procedure to ... Murrell MD, PhD, lead author from St. George Hospital ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Andrew Hawley of ... 1960's Who psychedelic concert posters. The Who and the Doors ... on August 2, 1968. According to Hawley, “The Who toured ... concert halls and college campuses. Perhaps the most famous Who ... Jim Morrison and the Doors on August 2, 1968 at ...
(Date:3/28/2015)... La Mirada, CA (PRWEB) March 28, 2015 ... with ear, nose and throat disorders, are ... Tinnitus is a common issue which is characterized by ... ears. Affecting 1 in 5 people, tinnitus is a ... or disorder and while it is non-fatal, tinnitus can ...
(Date:3/28/2015)... March 28, 2015 ARDX will sponsor the ... 12pm -3pm at the Chesapeake Conference Center in Chesapeake, Virginia. ... an empowering event for women in the Hampton Roads region. ... Stories of Women’s Lives. Women grow stronger through sharing ... other. This year the WWC™ theme is T-talk where ...
Breaking Medicine News(10 mins):Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:Avid Collector from Vintage Rock Posters, Inc. Announces His Search For Original 1960's Who Psychedelic Concert Posters. 2Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2
... Union asks board member to seek restatement of Beth ... Staples director Martin Trust,should apply the same Sarbanes-Oxley standards ... role on the board of Beth Israel Deaconess,Medical Center ... East. Trust is the CEO of Samtex and a ...
... Advisory Board Company,(Nasdaq: ABCO ) announced today ... Michael T. Kirshbaum, Chief Financial Officer and Robert,Musslewhite, ... upcoming investor conferences., Mr. Williams will present ... at,the UBS 18th Annual Global Healthcare Services Conference, ...
... in Long-Term Care: A Board of Directors Dashboard, ... Office of Inspector General (OIG) for the Department of ... Association (HCCA),present the challenges and opportunities for the boards ... of Care Dashboard." A,Quality of Care Dashboard is a ...
... Fla., Feb. 6 Mangrove Employer Services, a,leading ... Payroll, Benefits Administration and Self Service solutions,announces the ... Mangrove Employer Services teamed up with an ... in electronic benefits,payment services, in 2007 to provide ...
... NAPA, Calif., Feb. 6 Senetek PLC (OTC,Bulletin ... the development,of technologies that target the science of ... on Pyratine-6(TM) at the 66th Annual Meeting,of the ... In his presentation to the Academy, Dr. ...
... after , , WEDNESDAY, Feb. 6 (HealthDay News) -- An advanced ... harbingers of Alzheimer,s disease, can develop in just 24 hours. ... Hyman, leader of the group reporting the finding in the ... develop, damage is evident in nearby nerve cells almost immediately, ...
Cached Medicine News:Health News:Staples Board Member Should Use Sarbanes-Oxley Disclosure Rules in Non-Profit Role, Asserts 1199 SEIU 2Health News:The Advisory Board Company to Present at Upcoming Conferences 2Health News:OIG and HCCA Issue Government-Industry Roundtable Report 2Health News:Mangrove Announces Health Savings Account (HSA) and Health Reimbursement Account (HRA) Product Launches 2Health News:Dr. Neil Sadick Presents on Pyratine-6(TM) at the Annual Meeting of the American Academy of Dermatology 2Health News:Alzheimer's Plaques Can Form in One Day 2
...
Knot tier...
... The Blitz Suture Retriever is for arthroscopic and ... of design eliminates complicated procedural steps. It ... of suture material and in conjunction with,anchors or ... A small, curved needle tip permits the placement ...
... Blitz Suture Retriever is for arthroscopic and open ... design eliminates complicated procedural steps. It may ... suture material and in conjunction with,anchors or screws ... small, curved needle tip permits the placement of ...
Medicine Products: