Navigation Links
Surveyed EU5 Oncologists Plan Increased Uptake of Perjeta for HER2-Positive Breast Cancer, But Expect Reimbursement Hurdles for Perjeta Plus Kadcycla
Date:11/7/2013

BURLINGTON, Mass., Nov. 7, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that surveyed medical oncologists across the EU5 (France, Germany, Italy, Spain and the United Kingdom) currently prescribe Roche/Genentech's targeted agent Herceptin (with or without chemotherapy and/or hormonal therapy) to an average of half or more of their first-line HER2+ advanced breast cancer patients. Considering likely funding or reimbursement restrictions, respondents expect their prescribing of Roche/Genentech's Perjeta—which was approved in March 2013—in combination with Herceptin, will increase substantially from an average of no more than 12 percent of such patients currently to around one-quarter of patients in most countries by the end of 2016.

(Logo: http://photos.prnewswire.com/prnh/20130103/MM36784LOGO)

The new European Physician and Payer Forum report entitled Tightening Healthcare Budgets and Elevated Cost-Effectiveness Expectations: How Will Payers and Prescribers Prioritize Targeted Agents for Breast Cancer in the EU5? also finds that although half or more surveyed oncologists expect that Roche/Genentech's emerging HER2-targeting antibody drug conjugate Kadcyla in combination with Perjeta will likely demonstrate a significant efficacy benefit over single agent Kadcyla or Herceptin with chemotherapy in the advanced HER2+ first-line setting, less than 40 percent of respondents across the EU5 expect premium-priced Kadcyla/Perjeta combination is likely to be reimbursed in their country or region. Collectively, those surveyed anticipate that less than 10 percent of their first-line HER2+ advanced breast cancer patients will receive this combination by the end of 2016, highlighting evolving reimbursement and funding constraints as a major hurdle in achieving optimal uptake for emerging therapies.

The report also emphasizes interviewed EU5 payers' perspectives on the importance of high-cost therapies directly demonstrating a benefit in overall survival over a suitable comparator in order to justify their premium price tag. Interviewed payers stress that for HER2-targeted agents in particular, clinical trial design and efficacy outcomes will be subject to greater scrutiny in health technology assessments as this drug class becomes more crowded, owing to anticipated approvals of novel therapies and the emergence of trastuzumab biosimilars.

"Drug developers need to have effective marketing strategies which demonstrate the main advantages and long-term benefits of treatment with novel targeted therapies to encourage payers and prescribers to look beyond their high cost," said Decision Resources Senior Business Insights Analyst Gemma McConnell. "Increasing competition between current and emerging HER2-targeted therapies and the anticipated entry of less expensive biosimilar trastuzumab amid tightening healthcare budgets make such strategies particularly important in this market segment."

About Decision Resources
Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources Group company.

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.


'/>"/>
SOURCE Decision Resources
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. According to Surveyed Oncologists in the EU5, Zytiga Has Heavily Penetrated Second-Line Treatment of Metastatic Castrate-Resistant Prostate Cancer (mCRPC) and is Displacing Jevtana to Later-Line mCRPC
2. Surveyed U.S. and European Neurologists Agree that a Therapys Effect on Physical Disability is the Most Important Attribute Influencing Prescribing Decisions in Secondary-Progressive Multiple Sclerosis
3. Despite the Recent Availability of Xtandi, Zytiga Continues to Dominate the Second-Line Metastatic Castrate-Resistant Prostate Cancer Setting, According to Surveyed U.S. Oncologists and Urologists
4. Surveyed U.S. Physicians Indicate That Xarelto and Apixaban Will Benefit From the Lack of Use of a Fast-Acting Injectable Anticoagulant in the Treatment and Secondary Prophylaxis of Deep Vein Thrombosis/Pulmonary Embolism
5. Surveyed U.S. Neurologists Would Prescribe Biogen Idecs Tecfidera to 20 Percent of Their Patients with Relapsing-Remitting Multiple Sclerosis (RR-MS)
6. Surveyed U.S. Pulmonologists Expect to Treat Nearly 50 Percent of Their Severe, Refractory Asthma Patients With a Biologic or Biosimilar Version of Xolair By the End of 2018
7. For Treating Clostridium difficile Infections, Surveyed Infectious Disease Specialists Agree That Effect on Recurrence Rate is One of the Drug Attributes that Most Influences Their Prescribing Decisions
8. The Majority of Surveyed Gastroenterologists in the EU5 Identify Remicade as Their Most Preferred Biologic for the Treatment of Ulcerative Colitis
9. For Chronic Obstructive Pulmonary Disease, Surveyed Pulmonologists Indicate That Improved Effect on Quality of Life is One of the Greatest Unmet Needs
10. For Second- and Subsequent-Line Metastatic Castrate-Resistant Prostate Cancer, Surveyed Oncologists Indicate that Improved Symptom Control and Quality of Life is one of the Greatest Unmet Needs
11. Rising Drug Resistance is Driving Early-Line Use of Powerful Antibiotics Such as Carbapenems for Gram-Negative Infections, According to Surveyed EU5 Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... 5, 2016 Research ... "Europe Thalassaemia Market and Competitive Landscape Highlights ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... and Competitive Landscape Highlights - 2016, provides ... epidemiology, Thalassaemia market valuations and forecast, Thalassaemia ...
(Date:5/4/2016)... , May 4, 2016 BiondVax ... CEO, Dr. Ron Babecoff , will be attending the ... City . On Thursday, May 5, Dr. ... conference presented by Joseph Gunner & Co, taking ... BiondVax presentation that Dr. Babecoff will be using is downloadable ...
(Date:5/4/2016)... May 4, 2016 ... the  "Global Multiple Myeloma Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... and Competitive Landscape Highlights 2016, provides comprehensive ... Myeloma epidemiology, Multiple Myeloma market valuations and ...
Breaking Medicine Technology:
(Date:5/6/2016)... ... 2016 , ... Multiple award winning plumbing company in San Diego, ... Maintaining core values of exceptional customer service, quality work at reasonable rates, and giving ... in San Diego plumbing, and other services including heating & air conditioning and restoration ...
(Date:5/6/2016)... , ... May 06, 2016 , ... This Mother’s Day ... women everywhere. The 17th annual National Women’s Health Week takes place May ... Women’s Health are combining forces to empower women to make their health a top ...
(Date:5/5/2016)... ... May 05, 2016 , ... TransWipe Volume 3 is a set of 30 ... a TransWipe preset between two video clips to instantly add a unique transition to ... with customizable color and orientation options. TransWipe Volume 3 is a Final Cut Pro ...
(Date:5/5/2016)... ... May 05, 2016 , ... Textile Exchange is excited ... for public stakeholder review. The stakeholder review is an important opportunity for interested parties ... and delivers value to the wool industry., The RWS is intended to be a ...
(Date:5/5/2016)... Palm Beach, Fla. (PRWEB) , ... May 05, 2016 , ... ... Vision Institute in San Diego, California. The laser eye center will now be called ... recognized surgeons and attentive staff will remain at the full-service facility to ensure that ...
Breaking Medicine News(10 mins):