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Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism
Date:10/5/2007

the promising results seen to date, we strongly believe that SLx-4090 could play a significant role in the marketplace by providing clinicians another route to manage lipid disorders for patients who do not adequately respond to currently available treatment options."

Surface Logix is also exploring the use of SLx-4090 in other metabolic disorders, including obesity and diabetes.

SLx-4090 Phase 1 Repeat-Dose Study Design

The SLx-4090 Phase 1 repeat-dose study is a randomized, double-blind, placebo-controlled, dose escalating/dose decreasing study in 10 cohorts of 12 healthy male volunteers each. A variety of dosing regimens were included in the study. For subjects receiving SLx-4090, doses ranged from 25 mg to 200 mg, and dosing frequency in active and placebo arms ranged from once daily to three times daily. Treatment periods ranged from 5 to 14 days.

About SLx-4090 in Dyslipidemia

SLx-4090 is a novel microsomal triglyceride transfer protein (MTP) inhibitor being developed for the treatment of dyslipidemia (abnormal levels of lipids in the bloodstream). Surface Logix designed SLx-4090 using its proprietary small molecule Pharmacomer(TM) technology to act specifically in the gastrointestinal (GI) tract to prevent the transport of fats through the intestinal wall. This unique feature of intestinal selectivity allows potent activity against fat uptake while avoiding toxicity at other sites of MTP expression in the body including the liver, heart, testis, ovary, and eye.

Dyslipidemia currently affects approximately 10% of the global population, with 25% of these patients having elevated triglyceride levels. In addition, there is an increasing prevalence and medical need for lipid-modifying drugs in obese patients and patients with type 2 diabetes, as a high proportion of type 2 diabetic patients have abnormal concentrations of lipoproteins. In the U.S., Japan and Europe, it is estimated that there are more than 240 million people wit
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SOURCE Surface Logix, Inc.
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