Navigation Links
Surface Logix Achieves Objectives With SLx-2101 in Phase 2a Clinical Trial in Hypertension
Date:1/8/2008

l Sweetnam, Chief Scientific Officer at Surface Logix. "By leveraging our deep understanding of how small molecules interact with a variety of lipids and proteins, we succeeded in creating a drug candidate that is able to access PDE5 in cardiovascular tissue in a physiologically meaningful way. These Phase 2a clinical results of SLx-2101 demonstrate the translation of this property into therapeutic activity in hypertensive patients, a first for a PDE5 inhibitor."

The results from the trial provide further confirmation for the Pharmacomer(TM) Technology Platform designed by Surface Logix scientists to engineer specific PK and tissue distribution properties into a molecule while optimizing potency and selectivity. The design of SLx-2101 and its development program were directed to differentiate SLx-2101 from other PDE5 inhibitors based on the combined features of potency and an extended duration of action.

About the trial:

The Phase 2a study of SLx-2101 was a randomized, double-blind, placebo-controlled crossover trial, and was conducted at two centers in Europe. A total of 60 patients with uncontrolled hypertension, who were concurrently taking up to 3 marketed anti-hypertensive medications, received 5 mg or 10 mg oral doses of SLx-2101 once daily for up to 14 days. In addition to showing the safety and tolerability of the compound in these dosing regimens, blood pressure monitoring using standard measures (office seated & standing, central, home, and ambulatory) demonstrated that SLx-2101 caused clinically significant reductions in blood pressure.

About SLx-2101

SLx-2101 is an oral, potent, selective, fast-onset, long-acting PDE5 inhibitor designed specifically to expand the therapeutic potential of PDE5 inhibition beyond erectile dysfunction into larger cardiovascular markets such as hypertension. Clinical experience with SLx-2101 to date, including in ED, confirms its ability to positively impact endothelial function in a wide ra
'/>"/>

SOURCE Surface Logix, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Surface Logix, Inc. to Present at the Piper Jaffray Health Care Conference
2. Cantel Medical Corp.s Crosstex Subsidiary Addresses School MRSA Concerns With SaniTyze(TM) Brand Hand Sanitizer and Sanitex(R) Surface Disinfecting Line of Products
3. Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism
4. Keeping the Data Center Clean: ATEN Launches Industry-First KVM Switches with Antimicrobial Nanocoating to Protect Products from Bacteria Surviving on Surfaces
5. Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the OARSI 2007 World Congress on Osteoarthritis
6. Pharmasset Announces R7128 Achieves 85% Rapid Virologic Response in a 4-week Combination Study for the Treatment of Chronic Hepatitis C
7. PLC Systems Achieves Successful Early Conclusion of RenalGuard(TM) Pilot Safety Trial
8. Cethromycin Achieves All Endpoints in Second Pivotal Phase III Trial for Treatment of Pneumonia
9. Avastin Achieves Impressive Rate of Curative Surgery in Patients with Advanced Colorectal Cancer
10. Large Blinded Clinical Study Achieves High Accuracy for the Diagnosis of Melanoma Using In Vivo Confocal Microscopy
11. Trius Initiates U.S. Phase I Trial for its Oxazolidinone Antibacterial Drug, TR-701
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... addition of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses ... in the United States . Reimbursement ... studied. Thorough product analyses for more than 73 SMBG ...
(Date:12/22/2014)... Dec. 22, 2014  ConvaTec, a privately-held medical products ... been appointed Interim Chief Executive Officer of the company, ... Ken Berger .  "The Board of Directors of ... ConvaTec over the past three years," said Magnus ... "We are confident that the company is well positioned ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation ... focused on discovering, developing and commercializing innovative therapies ... today issued the following open letter to shareholders ... Dr. Med. Sc. Dear RXi Shareholders, ... number of inaccurate statements posted on certain social ...
Breaking Medicine Technology:US Self-monitoring Blood Glucose Market 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6
... Inc. (NASDAQ: VVUS ) today announced that ... review the company,s new drug application (NDA) for its investigational ... The target date for the FDA to complete its review ... announced results from the pivotal phase 3 trials, patients treated ...
... 2011 Kimberly-Clark Health Care (KCHC) announced today ... on synthetic exam gloves due to unprecedented demand ... butadiene and acrylonitrile.   "Despite aggressive ... along with inflationary pressures have been beyond expectations," ...
Cached Medicine Technology:VIVUS Announces FDA Acceptance of Avanafil New Drug Application for Treatment of Erectile Dysfunction 2VIVUS Announces FDA Acceptance of Avanafil New Drug Application for Treatment of Erectile Dysfunction 3
(Date:12/25/2014)... Among early stage breast cancer patients who undergo chemotherapy ... will eventually develop leukemia as a result of their ... from a review of more than 20,000 breast cancer ... that the risk for developing treatment-related leukemia, though low, ... "The frequency of bone marrow cancers such as leukemia ...
(Date:12/25/2014)... New York, New York (PRWEB) December 25, 2014 ... ) continue to move forward in a number ... Southern District of West Virginia, Bernstein Liebhard LLP reports. ... the Court is scheduled to convene a Joint Status ... 2015, at 10:00 a.m. Parties have been directed to ...
(Date:12/25/2014)... 2014 Residents at Abernethy ... showed their generous spirit by providing holiday gifts ... Parenting Network- Grandparents Raising Grandchildren program. , Following ... the largest Christmas tree on the campus of ... residents of the Abernethy Village Association (AVA). Each ...
(Date:12/24/2014)... Wauwatosa, Wi (PRWEB) December 25, 2014 ... who are unable to afford certain items. During the holiday ... , "We collected over 70 toys," says Dr. Sara Mahalko-Leonhardt, ... myself and staff such joy, knowing that we are able ... any present had it not been for the generosity of ...
(Date:12/24/2014)... Connie Casad, MD, a well-known and ... with 30 years of practice experience in Dallas, Texas, ... benefits of dietary detoxification. The second study is scheduled ... results from test patients who just completed a 21-day ... interest in conducting the study, Dr. Casad said, "About ...
Breaking Medicine News(10 mins):Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3
... , , ... outdoor ground-level ozone, microscopic particle pollution like smoke and smog, ... is sensitive to these airborne contaminants to experience shortness of ... and cause lung irritation(1). According to AIRNow.gov(2), a government-developed index ...
... from Columbia University Medical Center,s Herbert Irving Comprehensive Cancer Center ... make new neurons but that may be hijacked later ... called Huwe1 normally functions to eliminate other unnecessary proteins and ... cancer. These findings, published in the August 18 ...
... biologist, a physicist, and a nanotechnologist walk into a ..." ... the start of a collaboration that has helped to decipher ... cells divide. Errors in cell division can cause mutations that ... the role of chromosome abnormalities in uncontrolled cell replication. ...
... an MP3 device -- just about every man, woman and child on ... of music, of the primal place it holds in the human imagination. ... of the soul -- a frill that has to go when school ... The study shows that musicians -- trained to hear sounds embedded in ...
... good for your health, extreme exercise may be physically ... heroin addicts went into withdrawal after running excessively in ... the hardest had the most severe withdrawal symptoms. ... if excessive exercise is addicting, then maybe, to feel ...
... , , , EDINA, Minn., Aug. ... pain for millions of children and adolescents. As students prepare for school, ... to shed light on backpack safety. , , ... backpack pain and injuries. , , Does the ...
Cached Medicine News:Health News:Bad Air Day Alert: Outdoor Air Pollutants at High Level 2Health News:Bad Air Day Alert: Outdoor Air Pollutants at High Level 3Health News:Gene vital to brain's stem cells implicated in deadly brain cancer 2Health News:Gene vital to brain's stem cells implicated in deadly brain cancer 3Health News:Newly discovered mechanism in cell division has implications for chromosome's role in cancer 2Health News:Newly discovered mechanism in cell division has implications for chromosome's role in cancer 3Health News:Taking up music so you can hear 2Health News:Taking up music so you can hear 3Health News:Excessive exercise can be addicting, new study says 2Health News:It's Backpack Safety Time 2
... FSH Menopause Predictor Test is a ... detection of Follicle Stimulating Hormone (FSH) ... body hormone changes related to the ... menopause. The FHS Menopause Predictor ...
... pylori Rapid Test Strip and Device are ... of antibodies to Helicobacter pylori (H. pylori) ... aid in the diagnosis of H. pylori ... and older. They are intended for health ...
... Biotech Uni-Gold™ H. pylori assay is ... qualitative detection of IgG antibodies to ... human serum, plasma or whole blood ... of H. pylori infection in patients ...
Rapid Infectious Mononucleosis Heterophile Antibody (IgM) Test...
Medicine Products: