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Surface Logix Achieves Objectives With SLx-2101 in Phase 2a Clinical Trial in Hypertension
Date:1/8/2008

l Sweetnam, Chief Scientific Officer at Surface Logix. "By leveraging our deep understanding of how small molecules interact with a variety of lipids and proteins, we succeeded in creating a drug candidate that is able to access PDE5 in cardiovascular tissue in a physiologically meaningful way. These Phase 2a clinical results of SLx-2101 demonstrate the translation of this property into therapeutic activity in hypertensive patients, a first for a PDE5 inhibitor."

The results from the trial provide further confirmation for the Pharmacomer(TM) Technology Platform designed by Surface Logix scientists to engineer specific PK and tissue distribution properties into a molecule while optimizing potency and selectivity. The design of SLx-2101 and its development program were directed to differentiate SLx-2101 from other PDE5 inhibitors based on the combined features of potency and an extended duration of action.

About the trial:

The Phase 2a study of SLx-2101 was a randomized, double-blind, placebo-controlled crossover trial, and was conducted at two centers in Europe. A total of 60 patients with uncontrolled hypertension, who were concurrently taking up to 3 marketed anti-hypertensive medications, received 5 mg or 10 mg oral doses of SLx-2101 once daily for up to 14 days. In addition to showing the safety and tolerability of the compound in these dosing regimens, blood pressure monitoring using standard measures (office seated & standing, central, home, and ambulatory) demonstrated that SLx-2101 caused clinically significant reductions in blood pressure.

About SLx-2101

SLx-2101 is an oral, potent, selective, fast-onset, long-acting PDE5 inhibitor designed specifically to expand the therapeutic potential of PDE5 inhibition beyond erectile dysfunction into larger cardiovascular markets such as hypertension. Clinical experience with SLx-2101 to date, including in ED, confirms its ability to positively impact endothelial function in a wide ra
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SOURCE Surface Logix, Inc.
Copyright©2008 PR Newswire.
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