Navigation Links
SuperGen's PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models
Date:6/13/2008

DUBLIN, Calif., June 13 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced at the 13th Congress of the European Hematology Association (EHA) in Copenhagen, Denmark, that its lead, oral PIM kinase inhibitor, SGI-1776, causes tumor regression in acute myologenous leukemia (AML) xenograft models (abstract #744).

In a poster presentation entitled "A potent small molecule PIM kinase inhibitor with in vivo oral availability and activity in cell lines from hematological malignancies," Dr. Gregory Berk, SuperGen's Chief Medical Officer, detailed how scientists used SuperGen's CLIMB(TM) technology to build a model that allowed for the creation of small molecule PIM kinase inhibitors. SGI-1776 was identified as an orally available, potent and selective inhibitor of the PIM kinases. SGI-1776 induces cell cycle arrest, dose dependent apoptosis and a reduction in phospho-BAD levels in leukemia and lymphoma cell lines. Phospho-BAD is a direct substrate for PIM, and may serve as a useful in vivo biomarker for future clinical trials. Most notably, SGI-1776 induced significant tumor regression in MOLM-13 and MV-4-11 (AML) xenograft models.

"Our PIM kinase inhibitor, SGI-1776, has the potential to be an effective treatment for AML and other malignancies that over-express PIM kinase," said Dr. James Manuso, SuperGen's President and Chief Executive Officer. "The data also provide support for the use of our CLIMB(TM) technology to identify and rapidly advance candidates into the clinic. We plan to initiate Phase 1 clinical trials with SGI-1776 in solid tumors and leukemias
'/>"/>

SOURCE SuperGen Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Telik Announces Presentation of Preclinical Data on Dual Inhibitors of Aurora Kinases and VEGFR2
2. Telik Announces Preclinical Data Demonstrating Anti-Cancer Activity of Dual Inhibitors of Aurora Kinase and VEGFR2
3. Semafores PI3 Kinase Inhibitor SF1126 is Active Against Tumor and Tumor Cells and Synergizes with Standard Chemotherapy Agents
4. SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor
5. EntreMed to Highlight ENMD-2076 Kinase Inhibitor at 2008 AACR Annual Meeting
6. Semafores PI3 Kinase Inhibitor SF1126 is a Vascular Targeted Conjugate in Phase I Clinical Trials in Solid Tumors and Multiple Myeloma
7. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
8. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
9. Latest Cell Publication Describes the Novel Kinase Regulators Using OriGenes Functional Kinome Collection
10. Poniard Pharmaceuticals Licenses Kinase Inhibitors From The Scripps Research Institute
11. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Jan. 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ... therapies for operable and inoperable solid tumor cancers, announced today ... 7 th Annual Phacilitate Immunotherapy Forum in ... Phacilitate will take place on January 26 at 10:30 a.m. ...
(Date:1/23/2015)... 2015 More than a third of reproductive-aged women enrolled ... private insurance, filled a prescription for an opioid pain medication ... week,s Morbidity and Mortality Weekly Report (MMWR). ... moderate to severe pain.  They are also found in some ...
(Date:1/23/2015)... , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ... directors of Advaxis, Inc. ("Advaxis" or the "Company") (NASDAQ: ... breached its fiduciary duties to shareholders. On ... investing website reporting that Advaxis had misrepresented the clinical ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... 29, 2011 The Female Health Company (Nasdaq: ... conference call to discuss its operating results for the third ... 5, 2011 at 11:00 a.m. Eastern Time (EDT).  The Company ... Shareholders and other interested parties may participate ...
... AMGN ) reported total revenue increased 4 percent ... $3,804 million in the second quarter of 2010.  Total product ... to $3,893 million versus $3,613 million in the second quarter ... quarter of 2011 included a decline in other revenue due ...
Cached Medicine Technology:The Female Health Company to Host Third Quarter Conference Call on Friday, August 5, 2011 2Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 2Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 3Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 4Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 5Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 6Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 7Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 8Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 9Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 10Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 11Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 12Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 13Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 14Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 15Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 16Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 17Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 18Amgen’s Second Quarter 2011 Revenue Increased 4 Percent to $4.0 Billion 19
(Date:1/22/2015)... Lynchburg, Va. (PRWEB) January 22, 2015 Liberty ... Health Counseling (M.A.) program from the Council for ... The program, part of Liberty’s Center for Counseling & ... Hawkins, founding dean of the university’s new School of Behavioral ...
(Date:1/22/2015)... The City of West Hollywood hosted a news conference on ... anniversary of the Supreme Court decision Roe v. Wade, which legalized ... the Roe vs. Wade decision and the fight to protect a ... City of West Hollywood Councilmember Abbe Land. “We need to continue ...
(Date:1/22/2015)... 22, 2015 Gabe’s Chemo Duck Program is pleased ... first app ever created for kids with cancer. The Chemo Duck ... devices, is filled with enjoyable games to help children of all ... free app helps to keep kids entertained, educated and at ease ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who ... are thrilled to have it lead the wedding dress industry ... of prom dresses for the global market. , “The CEO ... and he focuses on continuing the goal of operational excellence ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2
... LAKE FOREST, Ill. and MINNEAPOLIS , ... Fitness Corporation (NYSE AMEX: FIT ) today announced that ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act in ...   http://www.newscom.com/cgi-bin/prnh/20090122/CG61641LOGO ) , On January 21, 2010 , ...
... WASHINGTON , Feb. 5 In response ... today, the American Veterinary Medical Association (AVMA) is reaffirming its ... help maintain and improve the health of U.S. livestock. , ... creating a new strategy for animal disease traceability. This comes ...
... ... San Francisco,s famed PIER 39 docks, was successfully rescued, rehabilitated and released back to the ... assembled at Rodeo Beach in the Marin Headlands, Sausalito, CA to watch as "Abagnale" made ... ...
... focus of new laws, online testing and Super Bowl plug ... improve treatment of concussions in youth sports are making headway ... in scholastic sports will get big play Sunday at Super ... can help athletic trainers and doctors determine when it,s safe ...
... LOS ANGELES , Feb. 5 Food 4 ... to support children,s hospitals in the communities its stores serve in ... Chicago area. In addition, the supermarket chain,s Foods Co ... California . , Customers and team members can support their ...
... Finding may further understanding of common diseases, researchers say , ... map of areas of the human genome that control which ... a finding that may advance understanding of the genetic ... the human genome is uncharted territory -- entire stretches of ...
Cached Medicine News:Health News:Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period 2Health News:Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period 3Health News:Trustmark and HealthFitness Announce Early Termination of Hart-Scott-Rodino Waiting Period 4Health News:AVMA Calls for Stronger Animal Disease Traceability System 2Health News:Entangled in Fishing Line then Rescued by The Marine Mammal Center - a Sea Lion Goes Back to the Ocean 2Health News:Entangled in Fishing Line then Rescued by The Marine Mammal Center - a Sea Lion Goes Back to the Ocean 3Health News:Entangled in Fishing Line then Rescued by The Marine Mammal Center - a Sea Lion Goes Back to the Ocean 4Health News:Concussion Awareness for Young Athletes Gets Big Play 2Health News:Food 4 Less Charitable Campaign to Benefit Children's Hospitals 2
The D.O.R.C. Silicone Oil is an ultra purified silicone oil which leads a maximum interfacial tension and minimizes interactions between tissues, cells and endo-tamponades media. (Sterile, 10 ml.)...
Eftiar® offers the vitreoretinal surgeon a temporary tamponade for efficient re-attachment of the retina, release of subretinal fluid, dissection of fibro-vascular proliferation and controlling r...
ROB-NEL Catheters (100% Latex-Free)...
Silver Foley Catheter 2-way...
Medicine Products: