Navigation Links
SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session
Date:10/25/2007

S110 preclinical data presented by Dr. Peter Jones, Director of USC's

Norris Cancer Center

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced as part of a series of presentations at the 2007 AACR-NCI-EORTC International Conference that S110, the Company's decitabine-derived DNA demethylating agent, shows improved pre-clinical activity due to increased drug delivery and stability (Poster 140). Additionally, Dr. Peter A. Jones, Director of USC's Norris Cancer Center, further discussed S110 in the plenary session on cancer epigenetics.

Poster B140 (Abstract No. 1038)

The Decitabine-derived Demethylating Dinucleotide S110 Shows Improved Activity Due to Increased Drug Delivery and Stability

Data presented in this poster explains how SuperGen scientists improved the stability of S110 over decitabine in human plasma. S110 demonstrated similar or improved activity compared to decitabine in re-expression of p15, p16, and MLH1 genes, which are silenced in cancer through methylation. S110 delivers decitabine with improved preclinical pharmacokinetics, and has a similar impact on HbF in non-human primates. The dinucleotide S110 is highly resistant to cytidine deaminase degradation in pre-clinical studies. This can potentially lead to longer half-life, improved bioavailability, and lower the dose requirement in patients, and therefore reduce toxicity.

Copies of the poster presentations will be available in the pipeline section of SuperGen's Web site: http://www.supergen.com

"SuperGen has achieved a leadership position in the development of epigenetic therapies with decitabine. S110 represents our continued commitment to this important therapeutic area. We look
'/>"/>

SOURCE SuperGen Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
2. Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science
3. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
6. Novel Mechanism Insights and Additional Data on CombinatoRx Drug Candidates to Be Presented at Upcoming EULAR Meeting
7. Roxro Pharma’s Novel Intranasal Pain Reliever Effective, Well Tolerated in Phase 3 Study
8. Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
9. Metabasis Therapeutics Presents Results of Preclinical Studies for MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, at the Endocrine Societys Annual Meeting
10. Encouraging Clinical Activity of GSKs Novel Cancer Immunotherapeutic Confirmed in Phase II Study in Patients with Most Common Form of Lung Cancer
11. Clinical Data on ARIADs Novel mTOR Inhibitor, AP23573, To Be Presented at the ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... , Oct. 22, 2014 Sanomedics International ... 2014 report by Global Research & Data Services, demand ... year from 2014 through 2018, as demand for more ... is the world,s largest market for thermometers, ... advanced thermometers is Sanomedics International Holdings, Inc. ...
(Date:10/22/2014)... and AUSTIN, Texas , ... PureMHC LLC today announced they have entered into ... antibody-based immunotherapies designed to target cancers. ... peptides displayed on the surfaces of tumor cells ... targets (PTTs), derived from proteins that play a ...
(Date:10/22/2014)... 2014  AcelRx Pharmaceuticals, Inc. (NASDAQ: ... IAP310 study have been published in Regional ... journal with broad, multidisciplinary readership. IAP310 was a ... and efficacy of Zalviso, also referred to as ... treatment of post-operative pain in patients following open ...
Breaking Medicine Technology:Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2Biotech Companies To Co-Discover And Co-Develop Antibodies Targeting Novel Phosphopeptide Tumor Targets 2AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2
... InfoLogix, Inc. (Pink Sheets: IFLG ), ... the healthcare and commercial industries, announced today that it ... Faire and Regional Conference, sponsored by HIMSS South Florida ... Grand Hotel in Davies, FL (situated North of Miami) ...
... Mass., Oct. 25 GENFIT (Alternext: ALGFT; ISIN: FR0004163111), ... and development, focusing on the early diagnosis and preventive ... it has been selected by Windhover as one of ... the cardiovascular/metabolic category. This announcement is part of the ...
Cached Medicine Technology:InfoLogix to Present at South Florida Healthcare Trade Faire & Regional Conference 2GENFIT Selected by Windhover for the 2011 'Top Biopharma Projects To Watch' 2GENFIT Selected by Windhover for the 2011 'Top Biopharma Projects To Watch' 3
(Date:10/22/2014)... 2014 Richard Carlson, Managing Partner of ... with over 25 years experience. Mr. Carlson is ... areas related to EDI, B2B Commerce, RFID and Internet/Intranet ... Advisory Board member for Pharmaceutical Commerce Magazine and a ... Group is a management and technology consulting firm focused ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Two sisters in ... heart damage. Ilina and Medha Krishen use electronic ... sounds of trouble in breathing patterns or heartbeats. ... in Michigan, wanted to find a way to detect ... pollutants. Using an electronic stethoscope, Ilina recorded one breath ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... officials on Monday officially tightened guidelines for health workers treating ... exposure and use of a respirator at all times. ... issue the tougher rules after two Dallas nurses contracted Ebola ... United States, Liberian national Thomas Eric Duncan. Nina Pham is ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is ... repair a damaged mitral valve as the heart continues ... by Abbott Vascular , is designed to treat ... in which the heart’s mitral valve leaflets fail to ... heart’s left ventricle into the left atrium. The heart ...
(Date:10/20/2014)... T.E.N., a technology and information security ... William H. Murray, renowned author and industry visionary, ... Award winner. Presented annually, the ISE® Luminary Leadership ... and industry practitioner for his or her distinguished ... security industry. , Formerly with IBM, Murray is ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4
... Accounting Related to Two Transactions , PHOENIX, Feb. 23 ... in stabilized rice bran (SRB) nutrient research and technology, ... recommendations of the Audit Committee of its Board of ... fiscal year ended December 31, 2007. This includes the ...
... Remember events to be held Feb. 27 - March 1 ... Feb. 23 FamilyLife, the global, donor-supported leader in marriage ... on Feb. 27 - March 1 and again March 20 ... conference aims to strengthen healthy marriages and heal troubled ones ...
... Feb. 23 Milestone Scientific Inc. (OTC Bulletin Board: ... announced that it will be exhibiting at the upcoming ... In light of its highly successful sales of the ... at last year,s CDS conference, coupled with four successive ...
... offers diabetes education, healthy food-sampling and a special performance ... History Month comes to a close, Grammy-nominated singer-songwriter Angie ... C onnected and E mpowered (F.A.C.E.) Diabetes ... Birmingham on February 28 to help empower and inspire ...
... 23 /PRNewswire/ -- DataMentors(R), the industry ... company, today announced the release of its much ... integrates data from multiple platforms. DataFuse is used ... mid-size and "Fortune 500" companies, providing the industry,s ...
... Drinks and Activia Fiber Bring Great Taste and Digestive ... The Dannon Company, Inc., announced today that it ... products to its probiotic portfolio. Both cultured fresh dairy ... Bifidus Regularis(TM), have the same scientifically proven benefits of ...
Cached Medicine News:Health News:NutraCea to Restate Financial Statements for 2007 and 2008 2Health News:NutraCea to Restate Financial Statements for 2007 and 2008 3Health News:NutraCea to Restate Financial Statements for 2007 and 2008 4Health News:NutraCea to Restate Financial Statements for 2007 and 2008 5Health News:FamilyLife Offers Economic Relief and Hope for Baltimore Marriages by Inviting Recently Unemployed Couples to Attend Marriage Conference for Free 2Health News:FamilyLife Offers Economic Relief and Hope for Baltimore Marriages by Inviting Recently Unemployed Couples to Attend Marriage Conference for Free 3Health News:Milestone Scientific to Exhibit at the Chicago Dental Society's 144th Midwinter Meeting 2Health News:Milestone Scientific to Exhibit at the Chicago Dental Society's 144th Midwinter Meeting 3Health News:Milestone Scientific to Exhibit at the Chicago Dental Society's 144th Midwinter Meeting 4Health News:Grammy-nominated Singer Angie Stone Encourages African-Americans in Birmingham to Fearlessly FACE Diabetes 2Health News:Grammy-nominated Singer Angie Stone Encourages African-Americans in Birmingham to Fearlessly FACE Diabetes 3Health News:Grammy-nominated Singer Angie Stone Encourages African-Americans in Birmingham to Fearlessly FACE Diabetes 4Health News:Industry Leading Data Quality and Householding Software Receives New Functionality for Enhanced Performance and Speed 2Health News:Dannon(TM) Expands Probiotic Portfolio with New Activia(TM) Extensions 2Health News:Dannon(TM) Expands Probiotic Portfolio with New Activia(TM) Extensions 3
The Vivid e delivers everything you need in a compact echo system, like complete cardiovascular functionality, a comprehensive cardiac measurement and analysis package, and full shared service capabi...
... is the first thrombectomy catheter to provide ... for the full range of thrombus removal ... new ThromCat™ System flushes, macerates, and extracts ... and incorporates advanced vessel-wall safety features. No ...
The ARK-730A initiates automatic measurement at the optimum measurement point. The ARK-730A maintains fogging throughout multiple measurements, saving total examination time....
... patented telescoping plate design integrates ... plate and vertebral column spacer. ... the need for supplemental fixation ... of bone graft to be ...
Medicine Products: