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SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session
Date:10/25/2007

S110 preclinical data presented by Dr. Peter Jones, Director of USC's

Norris Cancer Center

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced as part of a series of presentations at the 2007 AACR-NCI-EORTC International Conference that S110, the Company's decitabine-derived DNA demethylating agent, shows improved pre-clinical activity due to increased drug delivery and stability (Poster 140). Additionally, Dr. Peter A. Jones, Director of USC's Norris Cancer Center, further discussed S110 in the plenary session on cancer epigenetics.

Poster B140 (Abstract No. 1038)

The Decitabine-derived Demethylating Dinucleotide S110 Shows Improved Activity Due to Increased Drug Delivery and Stability

Data presented in this poster explains how SuperGen scientists improved the stability of S110 over decitabine in human plasma. S110 demonstrated similar or improved activity compared to decitabine in re-expression of p15, p16, and MLH1 genes, which are silenced in cancer through methylation. S110 delivers decitabine with improved preclinical pharmacokinetics, and has a similar impact on HbF in non-human primates. The dinucleotide S110 is highly resistant to cytidine deaminase degradation in pre-clinical studies. This can potentially lead to longer half-life, improved bioavailability, and lower the dose requirement in patients, and therefore reduce toxicity.

Copies of the poster presentations will be available in the pipeline section of SuperGen's Web site: http://www.supergen.com

"SuperGen has achieved a leadership position in the development of epigenetic therapies with decitabine. S110 represents our continued commitment to this important therapeutic area. We look
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SOURCE SuperGen Inc.
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