Navigation Links
SuperGen's Novel Hypomethylating Agent Highlighted at AACR Plenary Session
Date:10/25/2007

S110 preclinical data presented by Dr. Peter Jones, Director of USC's

Norris Cancer Center

SAN FRANCISCO, Oct. 25 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced as part of a series of presentations at the 2007 AACR-NCI-EORTC International Conference that S110, the Company's decitabine-derived DNA demethylating agent, shows improved pre-clinical activity due to increased drug delivery and stability (Poster 140). Additionally, Dr. Peter A. Jones, Director of USC's Norris Cancer Center, further discussed S110 in the plenary session on cancer epigenetics.

Poster B140 (Abstract No. 1038)

The Decitabine-derived Demethylating Dinucleotide S110 Shows Improved Activity Due to Increased Drug Delivery and Stability

Data presented in this poster explains how SuperGen scientists improved the stability of S110 over decitabine in human plasma. S110 demonstrated similar or improved activity compared to decitabine in re-expression of p15, p16, and MLH1 genes, which are silenced in cancer through methylation. S110 delivers decitabine with improved preclinical pharmacokinetics, and has a similar impact on HbF in non-human primates. The dinucleotide S110 is highly resistant to cytidine deaminase degradation in pre-clinical studies. This can potentially lead to longer half-life, improved bioavailability, and lower the dose requirement in patients, and therefore reduce toxicity.

Copies of the poster presentations will be available in the pipeline section of SuperGen's Web site: http://www.supergen.com

"SuperGen has achieved a leadership position in the development of epigenetic therapies with decitabine. S110 represents our continued commitment to this important therapeutic area. We look
'/>"/>

SOURCE SuperGen Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
2. Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science
3. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
6. Novel Mechanism Insights and Additional Data on CombinatoRx Drug Candidates to Be Presented at Upcoming EULAR Meeting
7. Roxro Pharma’s Novel Intranasal Pain Reliever Effective, Well Tolerated in Phase 3 Study
8. Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
9. Metabasis Therapeutics Presents Results of Preclinical Studies for MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, at the Endocrine Societys Annual Meeting
10. Encouraging Clinical Activity of GSKs Novel Cancer Immunotherapeutic Confirmed in Phase II Study in Patients with Most Common Form of Lung Cancer
11. Clinical Data on ARIADs Novel mTOR Inhibitor, AP23573, To Be Presented at the ASCO Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... 2015 Accelovance, Inc. (Accelovance), a global ... and General Medicine announced the completion of enrollment ... Heron Therapeutics, Inc. for the Phase 3 trial ... candidate SUSTOL® (granisetron injection, extended release) as part ... 1 receptor antagonist fosaprepitant and IV corticosteroid ...
(Date:7/7/2015)... 2015 Research and ... the "Deciphering Global Major Pharmaceutical Companies, New ... offering. It has been publicly recognized ... in a series of challenges in the recent ... significant overcapacities in small molecule product manufacturing; increasingly ...
(Date:7/7/2015)... 2015  PAREXEL International Corporation (NASDAQ: PRXL ) will ... 2015 on Wednesday, August 5 th , 2015 after the ... on PAREXEL,s website at www.PAREXEL.com and on the ... host a conference call and live webcast at 10:00 a.m. ... the results.  To access the webcast, visit PAREXEL,s website at ...
Breaking Medicine Technology:Accelovance Completes Trial Enrollment and Delivery of Clinical Data for Heron Therapeutics' Phase 3 Trial 2Deciphering Global Major Pharmaceutical Companies - New Outsourcing Demands and Strategies 2Deciphering Global Major Pharmaceutical Companies - New Outsourcing Demands and Strategies 3PAREXEL International Announces Date Of Fourth Quarter And Fiscal Year 2015 Earnings Release And Conference Call 2
... Cancer Patients With Improved Potential,to Battle Their ... --,Arrowhead Research Corporation announced today that two ... Calando,Pharmaceuticals Inc., are presenting data at the ... Meeting. The,presentations summarize the latest research findings ...
... ANGELES--(BUSINESS WIRE)--Apr 16, 2007 - Introgen Therapeutics,Inc. (NASDAQ:INGN) ... Los Angeles, California at the Annual Meeting of ... p53 tumor suppressor is one of the most,common ... action is targeted to restoring p53 tumor suppressor,function ...
Cached Medicine Technology:Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting 2Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting 3Arrowhead Subsidiaries Insert & Calando Present Data on,Cyclosert Drug Delivery System at AACR Meeting 4Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference 2Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference 3Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference 4
(Date:7/7/2015)... Dallas, TX (PRWEB) , ... July 07, 2015 , ... Ticket Down is a reputable ... Panama vs. Haiti and the United States vs. Honduras at the Toyota Stadium. ... today, July 7th at Toyota Stadium. The tournament, being held on American soil, will ...
(Date:7/7/2015)... ... ... The United States Centers for Disease Control and Prevention have awarded Fenway ... Coalition $3.78 million for a five-year HIV prevention partnership that will focus on ... the groups at highest risk of HIV infection in the US. Dubbed ...
(Date:7/7/2015)... ... July 07, 2015 , ... Illinois ... board is limited to permit holders. The Medical Cannabis Alliance of Illinois’ (MCAI) ... industry forward and are committed to making sure patients have access to cannabis ...
(Date:7/7/2015)... ... July 07, 2015 , ... Safe Catch is setting revolutionary purity limits for ... Gelson’s Markets, New Leaf Community Markets, Sprouts Farmers Market and Wegmans are some of ... to test every fish for mercury,” said Safe Catch co-founder Sean Wittenberg. “We launched ...
(Date:7/7/2015)... ... 07, 2015 , ... On Saturday, May 16th, 2015, the Manistee, MI chapter ... Country Club. Best Drug Rehabilitation staff members were delighted to join in for this ... International, the parent of the Manistee Kiwanis Club, is a global organization that works ...
Breaking Medicine News(10 mins):Health News:Panama vs Haiti & USA vs Honduras CONCACAF Group A Tickets at Toyota Stadium: Ticket Down Slashes Ticket Prices for Haiti vs Panama & USA vs Honduras in Frisco/Dallas 2Health News:Panama vs Haiti & USA vs Honduras CONCACAF Group A Tickets at Toyota Stadium: Ticket Down Slashes Ticket Prices for Haiti vs Panama & USA vs Honduras in Frisco/Dallas 3Health News:CDC Awards Fenway Health, AIDS Action, Multicultural AIDS Coalition $3.78m For ‘Getting To Zero’ HIV Prevention Partnership 2Health News:CDC Awards Fenway Health, AIDS Action, Multicultural AIDS Coalition $3.78m For ‘Getting To Zero’ HIV Prevention Partnership 3Health News:Cannabis Growers and Dispensaries Form Medical Cannabis Alliance of Illinois 2Health News:Safe Catch Launches Tuna with Lowest Mercury Limit of Any Brand 2Health News:Best Drug Rehabilitation Team Participates in Kiwanis Club Golf Outing Fundraiser 2
... lining of the womb may be damaged by heavy smoking, ... recent research. // ,The study revealed that smoking ... of the uterus difficult. ,The study was published ... rates for IVF using donated eggs for those who either ...
... have for the first time implicated the muscle protein myosin ... ,In a series of lab studies with human ... overproduction of myosin VI in both prostate tumor cells and ... 'silence' myosin VI, they discovered the cells were less able ...
... made from soy could play an important dietary role ... blood pressure, suggests new findings by University of Massachusetts ... Amherst scientists screened extracts from a sampling of dairy ... diabetes and hypertension in check, such as the activity ...
... transplants when they treated animals suffering from eye damages. // ... to that seen in many human eye diseases. They were ... their sight, leading to hopes that it could also benefit ... retinal stem cells were transplanted into the eye of the ...
... on-line consultations as an important additional tool in doctors' ... areas. // ,AMA President, Dr Mukesh Haikerwal, said ... that technology will add to medical encounters in the ... Statement on On-Line and Other Broadband Connected Medical Consultations, ...
... endemic among wild gorillas in Africa and its source of ... //,Statistics have shown that around 40 million people worldwide are ... with simian immunodeficiency virus (SIV) are said to be the ... in humans the source of the third has been unknown, ...
Cached Medicine News:Health News:'Muscle' Protein Drives Prostate Cancer 2Health News:Fruit Yogurt Could Play An Important Role In Diabetes Management 2Health News:Fruit Yogurt Could Play An Important Role In Diabetes Management 3Health News:Fruit Yogurt Could Play An Important Role In Diabetes Management 4Health News:Cell Transplants Can Even Help In Restoring Vision 2Health News:E-Consultations Given Go-Ahead 2Health News:Monkey Virus Identical to HIV Endemic in Gorillas 2
A single tube that performs two rapid tests for E. coli from culture. ColiScreen™ combines both the indole test with the glucuronidase test to increase the specificity....
Legionella provides rapid, accurate results that aid in the presumptive diagnosis of Legionella infection (Legionnaires' Disease)....
... The Trinity Biotech Captia™ ... Assay (ELISA) is intended for ... antibodies (IgG and IgM) to ... in serum from patients with ...
The GoodKnight® 425 Bi-Level® device is suitable for travel and includes features such as automatic altitude compensation, optional cigarette lighter adapter and portable battery pack...
Medicine Products: