Navigation Links
SuperGen's JAK2 Inhibitor, SGI-1252, Inhibits in Vivo Tumor Cell Proliferation
Date:6/16/2008

DUBLIN, Calif., June 16 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced at the 13th Congress of the European Hematology Association (EHA) in Copenhagen, Denmark, that SGI-1252, its JAK2 kinase inhibitor, prevents tumor cell proliferation in vivo (abstract #741).

In an oral presentation titled "SGI-1252: A Potent Small Molecule JAK2 Inhibitor," Dr. Steven Warner, Manager of Discovery Biology, highlighted how SuperGen scientists used the company's CLIMB(TM) technology to identify SGI-1252 as a possible JAK2 inhibitor. Dr. Warner presented data indicating that SGI-1252 selectively inhibits wildtype and mutant JAK2 activity in cancer cell lines, resulting in inhibition of STAT5 phosphorylation as well as a reduction in Bcl-XL expression. SGI-1252 was also shown to prevent tumor growth in mouse xenograft models. Pharmacokinetic studies indicate that SGI-1252 is orally bioavailable.

"SGI-1252 has shown potent and selective inhibition of JAK2 cellular signaling pathways that are involved in cancer cell proliferation. Moreover, as SGI-1252 does not target JAK3, we expect no negative clinical impact on patients' immune systems," said Dr. James Manuso, SuperGen's President and CEO. "We are optimistic that SGI-1252 may be effective in treating leukemia, lymphoma and myeloproliferative disorders and look forward to advancing this promising candidate into the clinic."

About SuperGen

Based in Dublin, Calif., SuperGen, Inc. is a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors an
'/>"/>

SOURCE SuperGen, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. SuperGens PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models
2. Semafore Pharmaceuticals Reports Positive Interim Results from a Phase I Study of SF1126, a Targeted Pan-PI3K Inhibitor, in Patients with Advanced Solid Tumors
3. Kosans Lead Hsp90 Inhibitor, Tanespimycin, Shows High Level of Activity in Trastuzumab Resistant/Refractory HER2-Positive Breast Cancer in a Phase 2 Trial
4. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
5. BiPar Sciences Announces Clinical Data Presentations on Lead PARP Inhibitor, BSI-201, at 40th American Society of Clinical Oncology Annual Meeting
6. BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer
7. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
8. SuperGens DNA Methyltransferase Inhibitor, S-110, Improves In Vivo Efficacy Profile of Decitabine
9. BiPar Sciences Expands Clinical Program for BSI-201, a Novel DNA Repair Inhibitor, in Brain Cancer
10. Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
11. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... , July 30, 2015 ... research report with market overview, trends, DRO ... porter analysis, recent developments, competitive scenario and ... Industry Insight: Biosensors Market Development and Demand ... http://photos.prnewswire.com/prnh/20150727/756778 ) Explore more ...
(Date:7/30/2015)... , July 30, 2015 Vermillion, ... on gynecologic disease, announced today it will ... after the market close on Thursday, August ... call and webcast at 4:30pm Eastern.Conference Call ... at 4:30pm Eastern/1:30pm Pacific  Domestic: ...
(Date:7/30/2015)... What can be expected from the ... grow at the fastest rates? Visiongain ,s brand ... data, trends, opportunities and prospects there. Our ... graphs. Discover the most lucrative areas in the industry ... you assess forecasted sales at overall world market and ...
Breaking Medicine Technology:Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 5Ophthalmic Devices Market Forecast 2015-2025 - Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 6
... 2011 The University of California, Los Angeles (UCLA) ... soon become the third oncology research center in the ... a privately held medical device company. ViewRay,s new research ... patented combination of radiotherapy delivery and simultaneous magnetic resonance ...
... Nearly three quarters of the medical ... from developed markets, but the next wave of growth is ... unique needs of the India market, according to preliminary findings ... which were presented today at AdvaMed 2011, the annual MedTech ...
Cached Medicine Technology:UCLA Health System - Jonsson Comprehensive Cancer Center to Acquire ViewRay Radiation Therapy Research System 2Made in India, for India, is Next Wave of Growth for Region's Medical Technology Sector 2Made in India, for India, is Next Wave of Growth for Region's Medical Technology Sector 3
(Date:7/30/2015)... ... July 30, 2015 , ... Google recently announced that it will be ... As discussed in a June 8, 2015 article published by Nasdaq , the ... been caused by its computer-driven cars, which such industry players as Tesla CEO Elon ...
(Date:7/30/2015)... ... July 30, 2015 , ... " DevExpress ” ... a look at small, medium, and large businesses making an impact in their ... business review and shared with viewers how DevExpress has provided software development tools ...
(Date:7/30/2015)... ... , ... 24/7 Care At Home, a high-quality provider of comprehensive home health ... Centers for Medicare and Medicaid (CMS) have awarded its agency the highest star rating ... Home’s agency is one of three top Orange County agencies to earn the 5-Star ...
(Date:7/30/2015)... ... July 30, 2015 , ... The need for accessibility is never greater than ... to patients as well as visiting friends and family during these critical moments, hospitals ... The stations - powered by ChargeItSpot , a Philadelphia-based startup that recently secured ...
(Date:7/30/2015)... ... July 30, 2015 , ... OncLive®’s extensive ... UCLA’s Jonsson Comprehensive Cancer Center (JCCC) mutually agreed to collaborate on projects ... editorial and marketing groups will help spread the news about the center’s leading-edge ...
Breaking Medicine News(10 mins):Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 2Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 3Health News:Software to Develop High-Performance Data-Driven Apps was Featured on NewsWatch Television 2Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2Health News:Hospitals Add Phone Charging Stations as an Amenity for Patients and Visitors 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 4
... Financial Flexibility - , , LAVAL, QC, June 25 ... ) today announced it has amended its debt facility agreement ... ). , Based on regulatory approval and recent launch of ... has been able to establish more favourable repayment terms. Under ...
... , Social commentator and vegan Ben Shaberman collects humorous ... , BALTIMORE, June 25 Apprentice House announces publication ... which guides readers through the world of being vegan, ... world of carnivores. Whether explaining how vegetarian guys ...
... , Product innovation designed to meet growing consumer demand for ... new line of High Fiber soups from Progresso(R), available in ... for taste, nutritional value and variety among ready-to-serve soups. , ... ingredient to positively impact health, 9 in 10 Americans are ...
... Can Help Americans Improve their Diets, Health and Energy , , NEW YORK, ... Friedrich today announced they are teaming up to help Americans make fitness and healthy ... and exercise, the partners will debut their " EB to ... etter + E at ...
... ... published in the British Journal of Nutrition (a Cambridge University Journal), clearly shows that ... , ... 2009 -- In a revolutionary healthcare finding, a peer-reviewed clinical study published in the ...
... , ... effort to more accurately reflect the service their Recruiters provide and the relationships they ... of their Recruiters to Career Consultants. , ... Omaha, NE (PRWEB) June 25, 2009 -- In an effort ...
Cached Medicine News:Health News:Labopharm amends debt facility agreement with Hercules 2Health News:Labopharm amends debt facility agreement with Hercules 3Health News:The Vegan Monologues Asks the Burning Question: Is That a Carrot in Your Pocket? 2Health News:Progresso(R) to Launch New High Fiber Soup Line in Fall 2009 2Health News:Eggland's Best and Award-Winning Fitness Trainer Cathe Friedrich Launch National Health and Fitness Program 2Health News:Eggland's Best and Award-Winning Fitness Trainer Cathe Friedrich Launch National Health and Fitness Program 3Health News:Eggland's Best and Award-Winning Fitness Trainer Cathe Friedrich Launch National Health and Fitness Program 4Health News:New Study Shows that Prebiotics, as Used by Jackson GI Medical, Increases Lifespan by 33% 2Health News:Traveling Healthcare Staffing Company, Medical Solutions, Announces a Ttitle change for its Recruiters to Career Consultants 2Health News:Traveling Healthcare Staffing Company, Medical Solutions, Announces a Ttitle change for its Recruiters to Career Consultants 3
Designed for instrumentation under magnification. Both lens and speculum can be swivelled. Open construction to allow access and examination under magnification and illumination....
Pocket-sized instrument with direct illumination. Avaliable in black, green or blue....
Pocket-sized instrument, powered by two AA-sized alkaline batteries. Built-in throat illuminator, rectangular viewing lens for instrumentation under magnification....
Provides 30% more illumination, high light output for true tissue. Wide-angle viewing lens, sealed system for pneumatic otoscopy....
Medicine Products: