Navigation Links
SuperGen's JAK2 Inhibitor, SGI-1252, Inhibits in Vivo Tumor Cell Proliferation
Date:6/16/2008

DUBLIN, Calif., June 16 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced at the 13th Congress of the European Hematology Association (EHA) in Copenhagen, Denmark, that SGI-1252, its JAK2 kinase inhibitor, prevents tumor cell proliferation in vivo (abstract #741).

In an oral presentation titled "SGI-1252: A Potent Small Molecule JAK2 Inhibitor," Dr. Steven Warner, Manager of Discovery Biology, highlighted how SuperGen scientists used the company's CLIMB(TM) technology to identify SGI-1252 as a possible JAK2 inhibitor. Dr. Warner presented data indicating that SGI-1252 selectively inhibits wildtype and mutant JAK2 activity in cancer cell lines, resulting in inhibition of STAT5 phosphorylation as well as a reduction in Bcl-XL expression. SGI-1252 was also shown to prevent tumor growth in mouse xenograft models. Pharmacokinetic studies indicate that SGI-1252 is orally bioavailable.

"SGI-1252 has shown potent and selective inhibition of JAK2 cellular signaling pathways that are involved in cancer cell proliferation. Moreover, as SGI-1252 does not target JAK3, we expect no negative clinical impact on patients' immune systems," said Dr. James Manuso, SuperGen's President and CEO. "We are optimistic that SGI-1252 may be effective in treating leukemia, lymphoma and myeloproliferative disorders and look forward to advancing this promising candidate into the clinic."

About SuperGen

Based in Dublin, Calif., SuperGen, Inc. is a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors an
'/>"/>

SOURCE SuperGen, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. SuperGens PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models
2. Semafore Pharmaceuticals Reports Positive Interim Results from a Phase I Study of SF1126, a Targeted Pan-PI3K Inhibitor, in Patients with Advanced Solid Tumors
3. Kosans Lead Hsp90 Inhibitor, Tanespimycin, Shows High Level of Activity in Trastuzumab Resistant/Refractory HER2-Positive Breast Cancer in a Phase 2 Trial
4. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
5. BiPar Sciences Announces Clinical Data Presentations on Lead PARP Inhibitor, BSI-201, at 40th American Society of Clinical Oncology Annual Meeting
6. BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer
7. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
8. SuperGens DNA Methyltransferase Inhibitor, S-110, Improves In Vivo Efficacy Profile of Decitabine
9. BiPar Sciences Expands Clinical Program for BSI-201, a Novel DNA Repair Inhibitor, in Brain Cancer
10. Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
11. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... 3, 2015 Un fournisseur ... que sont l,hypertension, le diabète et les troubles ... éducatives gratuites et d,une conférence majeure dédiée à ... ) , Les formations ... Prendre en charge l,hypertension en ligne ...
(Date:7/2/2015)... -- Pharma Major Lupin Limited anunció ... ZAO "Biocom" en Rusia bajo ciertas condiciones de ... en el mercado farmacéutico de Rusia que registró ... uno de los 10 principales mercados farmacéuticos del ... una década, el mercado farmacéutico ruso registró un ...
(Date:7/2/2015)... N.C. , July 2, 2015  New product ... of its leading role in educating thought leaders about ... that can heavily influence how well a new therapy ... new study from research and consulting leader Best Practices, ... leaders need to focus on are early stage thought ...
Breaking Medicine Technology:Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 3Lupin adquiere Biocom en Rusia 2Lupin adquiere Biocom en Rusia 3Medical Affairs Role in Thought Leader Education is Key Success Factor for New Product Launches in the Pharmaceutical Industry 2
... Not for release, publication or distribution, in whole or in ... where to do so would constitute a violation of the relevant laws ... BY ALERE AS HOLDINGS LIMITED ("ALERE AS HOLDINGS" OR ... FOR AXIS-SHIELD PLC ("AXIS-SHIELD" OR THE ...
... MIAMI and ATLANTA, Sept. 26, 2011 ASTRO Booth ... Oncology (ASTRO) 53rd Annual Meeting, October 2-6 in Miami ... solutions designed to simplify the complex processes involved in ... Elekta technology. "Radiotherapy techniques are becoming ...
Cached Medicine Technology:Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 2Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 3Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 4Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 5Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 6Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 7Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 8Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 9Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 10Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 11Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 12Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 13Alere Inc. Statement Amending Acceptance Condition to Axis-Shield Offer 14Elekta to Demonstrate How its Solutions Foster Confidence in Cancer Management at ASTRO Meeting in Miami 2Elekta to Demonstrate How its Solutions Foster Confidence in Cancer Management at ASTRO Meeting in Miami 3
(Date:7/3/2015)... ... July 03, 2015 , ... Smoothies are all the rage right now and ... accessible, quality ingredients. Aurora Natural is proud to introduce a new line of all ... protein, antioxidants, vitamins and minerals! , Aurora is offering a variety of blends and ...
(Date:7/3/2015)... ... 2015 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... reveal biblical truth and expose popular lies regarding proper relationships according to the bible. ... immediately goes into the core of the subject by explaining why certain types of ...
(Date:7/2/2015)... ... 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening of ... located in the Lone Star State. The premium frozen yogurt chain was listed as ... store, which opened July 1 at Duke’s Travel Plaza, is located at:, 30176 Hwy ...
(Date:7/2/2015)... ... 02, 2015 , ... With summer in full swing, Americans are flocking to Canada’s many lakes ... spots for fishing in the world, and it’s easy to understand why. From the Pacific ... fish. , Recreational fishing is a huge industry, and Americans make up the vast ...
(Date:7/2/2015)... PEACHTREE CITY, GA (PRWEB) , ... July 02, 2015 , ... ... introduce their newest innovation in compression socks designed for men. , For style ... compression socks into their daily routine. This is great news for men everywhere because ...
Breaking Medicine News(10 mins):Health News:Aurora Product, Inc. Announces An Original New Line: Smoothie Fixins’ 2Health News:Yisrayl Hawkins Explains What the Bible Really Says about Sex in New Publication This Week 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3
... Consumers need to know what,s ... in their seafood thanks to the Gulf Oil Spill. But in the long term, thoughts will ... putting consumers on notice that their new supplements are unique. , ... (PRWEB) June 14, 2010 -- The BP Gulf Oil Spill may put ...
... the Ecole Polytechnique Fdrale de Lausanne (EPFL) in Switzerland ... bladder become fluorescent and are more easily discoverable under ... the technique already in practice in Europe for ... is commercialized by Photocure and GE Healthcare as the ...
... ... out tasty Mediterranean diet recipes for home use across the world like never before. ... (PRWEB) June 14, 2010 -- ... most healthy) diets in the world. It,s origin is taken from the sixteen or so ...
... ... of premium dietary supplements, announces the release of their new sleep health supplement, ... ... direct-to-consumer provider of premium dietary supplements, announces the release of their new sleep ...
... advantage over uninsured or Medicaid patients, research shows , ... rectal cancer patients are more likely to die within ... due to disparities in treatment and cancer stage at ... reduced through health care reform, the researchers noted in ...
... Alabama at Birmingham (UAB) Comprehensive Cancer Center and UAB ... the U.S. Department of Defense Breast Cancer Research Program ... treatment encourage cancer,s spread to other parts of the ... altered genetic material (DNA) left in the body after ...
Cached Medicine News:Health News:Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements. 2Health News:Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements. 3Health News:Liberty Health shows how the BP Oil Spill may draw attention to the purity of the company's newly released Nutritional Supplements. 4Health News:Early detection of cancer: The FDA approves procedure discovered by EPFL researchers 2Health News:Monthly Release of Mediterranean Diet Weight Loss Recipes 2Health News:Purity Products Releases Ultimate Sleep Plus Melatonin 2Health News:Health Plan May Influence 5-Year Rectal Cancer Survival 2Health News:Are dead cancer cells feeding cancer's spread? 2
... Sur-Catch NT stone retrieval basket raises proven tipless, ... unique paired wire design and multi-sizing basket enable ... of each patient and procedure. Its highly ... with the DURTM-8 Elite Ureteroscope and its ergonomic ...
Simple, Effective Laparoscopic Irrigation Pumps from the Market Leader...
The Irrigation Pump for Bottle Fluids provides a range of flow rates by adjusting the pump pressure....
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
Medicine Products: