Navigation Links
SuperGen's DNA Methyltransferase Inhibitor, S-110, Improves In Vivo Efficacy Profile of Decitabine
Date:4/14/2008

Restored sensitivity to cisplatin observed in ovarian carcinoma xenografts

DUBLIN, Calif., April 14 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today announced as part of a series of presentations at the 2008 AACR Annual Meeting that S-110, its DNA methyltransferase inhibitor, improves in vivo efficacy of decitabine (Abstract No. 2613).

Entitled, "Decitabine administered as a Dinucleotide prodrug increases its in vivo efficacy due to enhanced drug delivery and stability," the poster highlights data indicating that S-110 showed robust anti-tumor activity in prostate and cisplatin-resistant ovarian carcinoma xenograft models. Additionally, S-110 restored sensitivity to cisplatin in the ovarian cancer model. Importantly, reduced toxicity was observed along with an increased half-life compared to decitabine.

"S-110's increased half-life, reduced toxicity and improvement of efficacy when compared to decitabine in its currently marketed formulations make it an attractive, next-generation hypomethylator for the treatment of hematoligic malignancies," said Dr. James Manuso, SuperGen's President and CEO. "As we develop S-110 further, we will continue to explore its potential to enhance solid tumors' sensitivity to standard chemotherapy agents, including cisplatin. We look forward to advancing this promising candidate to clinical trials later this year or early next year."

Copies of the 2008 AACR Annual Meeting poster presentations will be available in the pipeline section of SuperGen's Web site http://www.superg
'/>"/>

SOURCE SuperGen Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. BiPar Sciences Expands Clinical Program for BSI-201, a Novel DNA Repair Inhibitor, in Brain Cancer
2. Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
3. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
4. PTC Therapeutics Presents Encouraging Phase 1 Results of its Novel VEGF Inhibitor, PTC299, at 30th Annual San Antonio Breast Cancer Symposium
5. Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
6. Roches Investigational Polymerase Inhibitor, Combined with PEGASYS(R) and COPEGUS(TM), Shows Potent Antiviral Activity in Treatment of Chronic Hepatitis C at Four Weeks
7. Preclinical Data on Lead MEK Inhibitor, RDEA119, to be Presented at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
8. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
9. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
10. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
11. Ranolazine Shortens QT Interval and Improves Cardiac Relaxation in Study of Patients With Genetic Sodium Channel Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 By now, if you haven,t heard about ... this planet. The awareness campaign has brought this devastating disease ... raise over $88.5 Million (and counting) for ALS. Every day, ... are starting to as well. One such company, ... , who actually works with ALS sufferers and helps to ...
(Date:8/27/2014)...  Hill-Rom Holdings, Inc. (NYSE: HRC ) ... the Morgan Stanley Global Healthcare Conference on September 8, ... invited to listen to the live discussion via the ... directly at http://cc.talkpoint.com/morg007/090814a_ac/?entity=26_7CLOGQP .  A recorded replay of ... of the live event and accessible at the links ...
(Date:8/27/2014)... Mass. , Aug. 27, 2014 North American ... a prestigious R&D 100 Award for the new OSRAM ITOS ... and LED-based white light module for microscopy, endoscopy and surgical ... lamps with significantly higher efficacy and lamp life. ... as one of the most innovative new technologies of the ...
Breaking Medicine Technology:Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3
... April 12, 2011 Reportlinker.com announces that a new ... Europe Nephrology and Urology Devices Market Outlook ... Europe Nephrology and Urology Devices Market Outlook to ... new report, "Europe Nephrology and Urology Devices Market Outlook ...
... 12, 2011 Reportlinker.com announces that a ... its catalogue: Continuous Glucose ... Opportunity Assessment and Market Forecasts to 2016 ... Continuous Glucose Monitoring (CGM) Systems - ...
Cached Medicine Technology:Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 2Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 3Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 4Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 5Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 6Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 7Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 8Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 9Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 10Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 11Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 12Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 13Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 14Reportlinker Adds Europe Nephrology and Urology Devices Market Outlook to 2017 15Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 4Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 5Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 6Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 7Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 8Reportlinker Adds Continuous Glucose Monitoring (CGM) Systems - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 9
(Date:8/27/2014)... CA (PRWEB) August 27, 2014 Ticket ... vs. Chile tickets at Levi’s Stadium in Santa Clara. ... in Santa Clara, California just opened in July and will ... when Mexico takes on Chile. These are two of the ... the 2014 World Cup and will look to continue their ...
(Date:8/27/2014)... 2014 Sound Telecom, a leading telecommunications ... cloud-based business communication systems, has unveiled an article titled ... Secure Text Messaging .” The piece examines the world ... do to remain compliant with HIPAA and HITECH requirements. ... and C.O.O. at Sound Telecom, opens with evidence that ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Parker Waichman ... the rights of victims injured by defective medical devices, ... place for discovery procedures, specifically Collection and Preservation of ... Bard’s transvaginal mesh devices. (MDL No. 2187, In Re: ... the United States District Court, Southern District or West ...
(Date:8/27/2014)... a glass of wine at a time may keep you from ... 74 college students and staff to pour red and white wines ... wine in them. The participants were told to pour an amount ... about how much to pour -- such as limiting it to ... less wine than those without set guidelines. "About 70 percent ...
(Date:8/27/2014)... August 27, 2014 Power morcellator lawsuits ... courts on behalf of women who allegedly experienced the ... Liebhard LLP reports. According to court documents, one of ... in the U.S. District Court, Northern District of New ... the use of a power morcellator manufactured Karl Storz ...
Breaking Medicine News(10 mins):Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3Health News:Sound Telecom Releases Article on Secure Messaging with Huge Implications for the Healthcare Industry 2Health News:Sound Telecom Releases Article on Secure Messaging with Huge Implications for the Healthcare Industry 3Health News:New Discovery Rules Have Been Put in Place by the Court Overseeing C.R. Bard Transvaginal Mesh Litigation, Parker Waichman LLP Comments 2Health News:New Discovery Rules Have Been Put in Place by the Court Overseeing C.R. Bard Transvaginal Mesh Litigation, Parker Waichman LLP Comments 3Health News:New Discovery Rules Have Been Put in Place by the Court Overseeing C.R. Bard Transvaginal Mesh Litigation, Parker Waichman LLP Comments 4Health News:'Half a Glass' Rule May Curb Overdrinking 2Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 4
... also bring severe injury , , SUNDAY, June 29 (HealthDay ... of all ages should take precautions to ward off ... any kind of physical activity outside. , ... be successfully treated if such conditions are properly recognized ...
... behaviour is largely shaped by genetics and random ... largest study of twins. , Writing in the ... researchers from Queen Mary,s School of Biological and ... that genetics and environmental factors (which are specific ...
... this process does not provide our veterans with the ... serve those who so dutifully served us., JAMAICA, ... Gregory W. Meeks (D-NY) of the Sixth Congressional,District, announced ... B.,Peake to suspend the Capital Asset Realignment for Enhanced ...
... B-Sure Incontinence and Personal Care product line by ... managing mild anal incontinence and for everyday personal ... provide rectal, vaginal, and perineal cleanliness while relieving ... products help decrease anxiety while improving quality of ...
... Relations Firm Brings Unique Expertise to the Beltway , ... ... Relations, Inc., a full-service PR firm exclusively serving healthcare, technology and ... office, bringing its unique media relations approach and public policy expertise ...
... Health care facilities,in the U.S. are entering ... (HAI). Could there be hidden areas of,infection that ... program,from the production company Mission Critical attempts to ... of Infection,",( http://www.missioncriticaltv.com/index-8-1.html ) documents how an acute,care ...
Cached Medicine News:Health News:Activity-Linked Heat Illness Needs Prompt Attention 2Health News:Activity-Linked Heat Illness Needs Prompt Attention 3Health News:Homosexual behavior due to genetics and environmental factors 2Health News:Congressman Gregory W. Meeks to Ask for Suspension of CARES Process at the St. Albans Veteran Campus 2Health News:Birchwood Laboratories Expands B-SURE™ Incontinence and Personal Care Product Line™; Three New Products Added Including B-SURE Fresh 'n Go™, B-SURE Bottom Balm™ and B-SURE Traveler™ 2Health News:Ricochet Public Relations Opens Washington, D.C. Office 2Health News:Ricochet Public Relations Opens Washington, D.C. Office 3Health News:Hidden Areas of Infection in U.S. Hospitals 2Health News:Hidden Areas of Infection in U.S. Hospitals 3
Inoculum Broth...
Inoculum Broth with Calcium Chloride and Phytone....
... ready-to-use solutions ideal for a wide range ... prepared with 18 megOhm water, filtered using ... sterile bottles., Reliable - Manufactured according ... lot-to-lot consistency. , High Quality - ...
12% Tryptone, 24% Yeast Extract, 4.0% Glycerol. Supplied with 1 liter of 10x phosphate buffer (0190-1L)....
Medicine Products: