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SuperGen Comments on Preliminary Efficacy Update on EORTC Phase 3 Trial of Dacogen(R) Versus Supportive Care in Patients With Myelodysplastic Syndromes
Date:7/1/2008

Reiterates 2008 Annual Financial Guidance

DUBLIN, Calif., July 1 /PRNewswire-FirstCall/ -- SuperGen Inc. (Nasdaq: SUPG), a pharmaceutical company dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, today commented on the preliminary efficacy data from a trial, initiated in 2002, comparing Dacogen(R) (decitabine) for Injection to best supportive care (BSC) in elderly patients with myelodysplastic syndromes (MDS). The data did not demonstrate a statistically significant advantage of Dacogen treatment on median survival compared to BSC, the primary endpoint of the study. However, response rates were similar to those observed in other clinical trials of Dacogen in patients with MDS. The trial, conducted by the European Organisation for Research and Treatment of Cancer (EORTC), administered Dacogen on a three-day dosing schedule in which the number of treatment cycles was limited. MDS is a potentially life-threatening group of bone marrow diseases that limit the production of functional blood cells.

Subsequent to database lock and the completion of data analysis, comprehensive results of the study, including secondary efficacy endpoints and safety data, will be presented by EORTC at an upcoming scientific forum.

2008 Annual Financial Guidance Update

The Company reiterates its 2008 annual financial guidance provided during the 2008 first quarter financial conference call on April 28, 2008. As indicated in the 2008 first quarter financial conference call, the Company expects to report royalty revenue for 2008 in a range from $32 million to $35 million. Also, the Company continues to estimate a loss from operations for 2008 in a range from $17 million to $19 million.

The Company's financial position at March 31, 2008 included approximately $91 million in unrestricted cash, cash equivalents and marketable securities and no debt.

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