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Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research
Date:4/9/2008

SOUTH SAN FRANCISCO, Calif., April 9, 2008 /PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS) today announced that the company will present data on each of its clinical-stage anticancer compounds at the upcoming Annual Meeting of the American Association for Cancer Research (AACR) being held April 12-16 in San Diego, CA. Sunesis has built a portfolio of product candidates in oncology focused on novel pathways and targets, including inhibition of the cell cycle and survival signaling.

Data from non-clinical studies of SNS-595, SNS-032 and SNS-314 will be presented in five posters and one oral presentation during the AACR Meeting. New insights on the mechanism of action and anticancer activity of SNS-595, Sunesis' lead compound, will be featured on Monday, April 14, 2008. SNS-595 is a novel naphthyridine analog structurally related to quinolones, a class of compounds which has not been used previously for the treatment of cancer. SNS-595 both selectively intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent DNA damage, irreversible G2 arrest and rapid apoptosis. A Phase 2 single agent clinical trial of SNS-595 in ovarian cancer and a Phase 1b combination clinical trial with cytarabine in relapsed/refractory acute myeloid leukemia are both ongoing.

SNS-595 Poster Presentations

Monday, April 14, 2008

-- SNS-595 is a potent anti-tumor agent that has a dual mechanism of

action: DNA intercalation and site-selective topoisomerase II poisoning

Session: Stress Responses

Abstract #1860

8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center

-- Sensitivity to SNS-595 is related to activation of double strand DNA


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SOURCE Sunesis Pharmaceuticals, Inc.
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