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Sunesis Pharmaceuticals Reports Preliminary SNS-595 Activity in Ovarian Cancer Clinical Trial at AACR-NCI-EORTC International Conference
Date:10/23/2007

Criteria to Advance SNS-595 to Next Stage of Phase 2 Trial Achieved

SOUTH SAN FRANCISCO, Calif., Oct. 23 /PRNewswire-FirstCall/ -- /ADVANCE FOR RELEASE AT 3:30 P.M. EDT, TODAY/ -- Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS), a clinical-stage biopharmaceutical company developing novel anticancer therapeutics, today announced positive preliminary results from the first stage of the company's ongoing Phase 2 clinical trial of its lead product candidate, SNS-595, in platinum-resistant ovarian cancer patients.

Administered as a single agent, SNS-595 demonstrated anti-tumor activity, with 88 percent (15 of 17) of evaluable patients having best responses of stable disease or better, including two partial responses (PRs). Based on these results, SNS-595 has achieved the pre-specified criterion (two or more responses) for proceeding to Stage 2 of this trial.

Patients received SNS-595 once every three weeks by IV infusion for up to eight cycles. SNS-595 was generally well tolerated at the current dosing level among nineteen patients with sufficient follow-up to yield safety data. Incidence of febrile neutropenia was 11 percent (2 of 19) among these patients. In addition, five percent (1 of 19) of these patients experienced grade 3/4 nausea and 11 percent (2 of 19) of these patients experienced grade 3/4 fatigue.

"SNS-595 appears to be a promising novel agent for platinum resistant ovarian cancer," said Ursula Matulonis, M.D., Director of Medical Gynecologic Oncology at the Dana-Farber Cancer Institute. "This patient population remains underserved, and the initial stable disease and responses achieved thus far are encouraging. I look forward to seeing the continued progress of SNS-595 in this indication
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SOURCE Sunesis Pharmaceuticals, Inc.
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