Sunesis Pharmaceuticals Presents Updated Clinical Data From Ongoing Phase 2 Trial of Voreloxin (Formerly SNS-595) in Ovarian Cancer Patients at the 44th ASCO Annu...( Positive Interim Safety ...),Health

Positive Interim Safety and Efficacy Data Reported

Trial Enrollment Advancing Ahead of Schedule

SOUTH SAN FRANCISCO, Calif., May 31 /PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS) today presented an update of interim data from the company's ongoing Phase 2 clinical trial of its lead product candidate, voreloxin (formerly SNS-595), in platinum-resistant ovarian cancer patients at the 44th American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois.

"Voreloxin is a promising anti-cancer agent demonstrating encouraging signs of single-agent clinical activity in ovarian cancer patients who have failed prior rounds of treatment," said William McGuire, M.D., Medical Director of the Harry and Jeanette Weinberg Cancer Institute at Franklin Square and principal investigator for the Phase 2 clinical trial. "Importantly, treatment with voreloxin has resulted in disease control among approximately half of patients treated and the drug has been very well tolerated. Taken together, these data support a potentially broad therapeutic window for this product candidate and I look forward to seeing the outcomes of treatment with voreloxin at the higher dose levels for patients now enrolling in this study."

To date, voreloxin administered as a single agent at a dose of 48 mg/m(2) once every 21 days has demonstrated clinical activity in platinum-resistant ovarian cancer patients. Thus far, of 62 women evaluable for best response at that dose, one patient had a complete response, five patients had partial responses (one unconfirmed) and forty-five patients achieved stable disease. Forty-eight percent of these 62 patients achieved disease control, defined as stable disea
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