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Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association
Date:6/16/2008

Data from Phase 1 Single Agent and Phase 1b Combination Clinical Trials

Demonstrate Voreloxin's Anti-Leukemic Activity

SOUTH SAN FRANCISCO, Calif., June 16 /PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS) presented data Saturday from two clinical trials of the company's lead drug candidate, voreloxin (formerly SNS-595), including updated results of a Phase 1 trial of voreloxin when used as a single agent in relapsed or refractory patients with acute myeloid leukemia (AML) and preliminary data from a Phase 1b trial of voreloxin in combination with cytarabine in patients with relapsed/refractory AML.

"Voreloxin has demonstrated anti-leukemic activity as a single agent and is showing encouraging early response data when administered in combination with cytarabine. Importantly, it has also been generally well tolerated, even among patients older than 60 and patients with AML with poor risk features," said Judith E. Karp, M.D., Director, Adult Leukemia Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and an investigator for the Phase 1 and Phase 1b clinical trials of voreloxin in AML. "Voreloxin appears to be a promising new drug for the treatment of AML and I look forward to the results of continued clinical investigation."

Analysis of Safety and Response Data for Older AML Patients Supports Phase 2 REVEAL-1 Trial

Researchers presented an analysis of comparative safety, pharmacokinetic and response data from Sunesis' Phase 1 dose-escalating trial of single-agent voreloxin comparing results from older patients (age >/= 60) with those from younger patients (age < 60). Overall, voreloxin demonstrates a similar safety profile in both older and you
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SOURCE Sunesis Pharmaceuticals, Inc.
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3. Sunesis Pharmaceuticals to Present Interim Clinical Data From Voreloxin (Formerly SNS-595) Ovarian Cancer Trial at 44th ASCO Annual Meeting and Acute Myeloid Leukemia Trials at 13th EHA Congress
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