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Sunesis Pharmaceuticals Initiates Phase 2 Clinical Trial of Voreloxin (SNS-595) in Acute Myeloid Leukemia
Date:5/21/2008

drug nomenclature by working closely with the International Nonproprietary Name Programme of WHO and various national nomenclature groups.

About Voreloxin (SNS-595)

Voreloxin (also known as SNS-595) is a novel naphthyridine analog, structurally related to quinolones, a class of compounds which has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site- selective DNA damage, irreversible G2 arrest and rapid apoptosis. The topoisomerase II-associated DNA intercalation and DNA damage produced by voreloxin show greater selectivity for proliferating cells.

In nonclinical evaluations, voreloxin demonstrates broad and potent activity in tumor biopsies and in xenograft, syngeneic and drug-resistant tumor models. In addition to the REVEAL-1 Phase 2 clinical trial in elderly AML patients, voreloxin is being evaluated in combination with cytarabine in a Phase 1b clinical trial and as a single agent in a Phase 2 clinical trial in platinum-resistant ovarian cancer. In clinical trials conducted to date, voreloxin has been generally well tolerated and has shown objective responses in both solid and hematologic tumor types.

About Acute Myeloid Leukemia

AML is a rapidly progressing cancer of the blood characterized by the uncontrolled proliferation of immature blast cells in the bone marrow. The American Cancer Society estimates that over 13,000 new cases of AML will be diagnosed and approximately 8,800 deaths from AML will occur in the U.S. during 2008. AML is generally a disease of older adults and the median age of a patient with AML is about 67 years. A majority of elderly patients are not considered candidates for standard therapy or decline therapy, resulting in an acute need for new treatment options.

About Sunesis Pharmaceuticals

Sunesis is a clinical-stage biopharmaceutical company focused on the discovery, development and c
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SOURCE Sunesis Pharmaceuticals, Inc.
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