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Sunesis Pharmaceuticals Commences Clinical Trials of SNS-595 and SNS-314
Date:9/12/2007

," said Daniel C. Adelman, M.D., Senior Vice President, Development and Chief Medical Officer at Sunesis.

"We're also excited to be treating patients for the first time with SNS-314, our internally discovered Aurora kinase inhibitor. SNS-314 has shown broad anti-tumor activity across a number of tumor models, and selective and specific activity against Aurora kinases in non-clinical studies," Dr. Adelman continued.

About SNS-595

SNS-595 is currently in Phase 1 and Phase 1b acute leukemia clinical trials and a Phase 2 ovarian cancer clinical trial. SNS-595 is a replication- dependent DNA damaging agent that causes irreversible growth arrest of proliferating cells and rapid apoptosis. In clinical trials conducted to date, SNS-595 has been well tolerated and has shown promising signs of clinical activity in both solid and hematological tumor types. In non- clinical evaluations, SNS-595 demonstrates broad and potent activity in xenograft, syngeneic and drug-resistant models.

About SNS-314

Discovered by Sunesis using the company's discovery platform, SNS-314 is a potent and selective inhibitor of Aurora kinases A, B and C. SNS-314 targets the uncontrolled cellular proliferation associated with cancer by halting cell division at the mitotic phase of the cell cycle. Aurora kinases are key enzymes involved in cancer cell division and have a central role in the abnormal proliferation of tumors.

About Sunesis Pharmaceuticals

Sunesis is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of novel small molecule therapeutics for oncology and other serious diseases. Sunesis has built a broad product candidate portfolio through internal discovery and in-licensing of novel cancer therapeutics. Sunesis is advancing its product candidates through in-house research and development efforts and strategic collaborations with leading pharmaceutical and biopharmaceutical companies. For additional
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SOURCE Sunesis Pharmaceuticals, Inc.
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