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Sunesis Pharmaceuticals Commences Clinical Trials of SNS-595 and SNS-314
Date:9/12/2007

SOUTH SAN FRANCISCO, Calif., Sept. 12 /PRNewswire-FirstCall/ -- Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS) announced today that patient dosing has commenced in clinical trials to evaluate two of the company's anti-cancer product candidates, SNS-595 and SNS-314.

Sunesis' lead product candidate, SNS-595, is being evaluated in combination with cytarabine in a Phase 1b clinical trial of patients with relapsed and/or refractory acute leukemias. This clinical trial is designed to evaluate the safety, tolerability and initial indications of anti-cancer activity of escalating doses of SNS-595 when administered with a fixed dose of cytarabine. Non-clinical studies demonstrated that SNS-595 acts synergistically with cytarabine, the current standard of care in acute leukemias.

SNS-314, an Aurora kinase inhibitor, is being studied in its first clinical trial. The Phase 1 dose-escalating trial of SNS-314 in patients with advanced solid malignancies will examine safety and tolerability, as well as preliminary anti-tumor activity. The open-label trial is being conducted by leading investigators at five U.S. clinical sites. Patients in this trial will receive three once-weekly doses of SNS-314 per four-week cycle. In non-clinical studies, SNS-314 demonstrated robust anti-tumor activity in tumor models of diverse tissue types.

"We are pleased to have these two trials up and running. In addition to the single-agent activity we've observed for SNS-595 in acute leukemia patients, SNS-595 has demonstrated impressive synergy with cytarabine in non-clinical studies. Testing the potential benefits of a combination regimen is a key element of our comprehensive strategy to develop SNS-595 for the treatment of acute leukemia
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SOURCE Sunesis Pharmaceuticals, Inc.
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