Navigation Links
Sunesis Pharmaceuticals Announces Presentation of Voreloxin Clinical Data in Patients with Acute Myeloid Leukemia at the 50th Annual Meeting of the American Society of Hematology
Date:12/7/2008

>

Phase 1b/2 Study of Voreloxin in Combination with Cytarabine in Relapsed/Refractory AML

Researchers also presented interim data from an ongoing Phase 1b/2 clinical trial testing voreloxin in combination with cytarabine. The Phase 1b/2 trial is designed to evaluate the safety, pharmacokinetics and anti-leukemic activity of escalating doses of voreloxin when administered on days one and four with a fixed dose of cytarabine given either as a continuous infusion (Schedule A) or as a daily IV bolus (Schedule B) for five days.

To date, 45 patients have been treated in Schedule A and preliminary data is available for 38 patients in the dose escalation portion of the study. Nine of these 38 patients have achieved a CR or CRp in voreloxin dose cohorts ranging from 20 to 90 mg/m(2). Complete remissions have been observed in both relapsed and in treatment refractory AML patients. Schedule A has also been generally well tolerated with an acceptable safety profile in this heavily pretreated population. A maximum tolerated dose (MTD) of 80 mg/m(2) of voreloxin was established for Schedule A, and AML patients in first relapse are now being enrolled at the MTD in the Phase 2 portion of this study.

Single agent cytarabine is the current treatment standard for relapsed AML patients dosed across a range of different dose levels administered by either bolus infusion or 24 hour continuous infusion with typical remission rates of approximately 20 percent. Schedule B was recently opened for enrollment with a starting dose of voreloxin at 70 mg/m(2) on days one and four. The first cohort of patients has been fully enrolled in Schedule B.

"Voreloxin has demonstrated anti-leukemic activity when administered in combination with cytarabine," said Judith E. Karp, M.D., Director, Adult Leukemia Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and an in
'/>"/>

SOURCE Sunesis Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia To Be Presented at ASH
2. Sunesis Pharmaceuticals Presents Clinical Trial Data of Voreloxin in Patients with Acute Myeloid Leukemia and Ovarian Cancer at the Chemotherapy Foundation Symposium
3. SARcode and Sunesis Announce Start of Phase 1 Clinical Trial in Ocular Inflammatory Diseases
4. Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association
5. Sunesis Pharmaceuticals Focuses Resources on Development of Voreloxin (Formerly SNS-595)
6. Sunesis Pharmaceuticals Presents Updated Clinical Data From Ongoing Phase 2 Trial of Voreloxin (Formerly SNS-595) in Ovarian Cancer Patients at the 44th ASCO Annual Meeting
7. Sunesis Pharmaceuticals to Present Interim Clinical Data From Voreloxin (Formerly SNS-595) Ovarian Cancer Trial at 44th ASCO Annual Meeting and Acute Myeloid Leukemia Trials at 13th EHA Congress
8. Sunesis Pharmaceuticals Initiates Phase 2 Clinical Trial of Voreloxin (SNS-595) in Acute Myeloid Leukemia
9. Sunesis Pharmaceuticals Reports Data from Nonclinical Studies of SNS-032 at the Annual Meeting of the American Association for Cancer Research
10. Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research
11. Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... -- The U.S. Department of Health and Human Services (HHS) ... Case Medical Center Seidman Cancer Center totaling $4.7 million ... care for patients with complex cancer. ... unique model developed at UH to enhance care for ... demonstrated need for high health care utilization.  ...
(Date:7/10/2014)... WEST JORDAN, Utah , July 10, 2014 /PRNewswire/ ... imaging solutions, and MiE America , Inc., a ... systems, have entered into a long-term agreement naming BC ... in the US. MiE and BC ... a strategic agreement to establish BC Technical as the ...
(Date:7/10/2014)... 10, 2014 CVS Caremark Corporation (NYSE: ... approved a quarterly dividend of $0.275 (27.5 cents) per share ... August 1, 2014, to holders of record on July 21, ... Caremark is dedicated to helping people on their path to ... the United States . Through the company,s more ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... 2011 In an effort to boost prescription drug ... LLC, to help promote the Didit® – one of ... and confusion of taking prescription medications. (Photo: ... simple device that sticks to any prescription container. Consumers ...
... The U.S. Food and Drug Administration announced today ... of amino-acid products marketed to treat a number of ... Cosmetic Act are met. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ... doing business as CHK Nutrition, and NeuroResearch Clinics Inc., ...
Cached Medicine Technology:Rexam Teams with Didit to Enhance Prescription Drug Compliance 2FDA: Minnesota Companies Agree to Halt Sale of Amino-acid Products with Unapproved Claims 2FDA: Minnesota Companies Agree to Halt Sale of Amino-acid Products with Unapproved Claims 3
(Date:7/14/2014)... Dry eyes, contrary to popular opinion, are not ... have pointed out, today’s technology has practically enabled younger and ... result of using laptops and smartphones to go about ... this phenomenon, it has become imperative for people of today ... from having dry eyes, but prevent it from ever happening ...
(Date:7/14/2014)... Sometimes, thinking “inside the box” can be ... first product release, Joyboxx™ - The world’s only hygienic ... , Inventor and CEO, Deborah Semer began designing a ... solution for their ‘toys’ after she realized no such ... , Semer met 30-year industry veteran Phyllis Heppenstall, the ...
(Date:7/14/2014)... NATURALLY, DANNY SEO, a new magazine from ... a Fall issue that hits newsstands nationwide on July ... healthy, natural and good for you life with a ... travel, home, and entertaining all through Danny’s unique point-of-view ... of gimmicky weight loss tips and fluffy celebrity profiles, ...
(Date:7/14/2014)... July 14, 2014 The Cabin Chiang ... its new Alumni Community website – a ... to help them maintain lifelong recovery wherever they live ... providing clients the tools to help them maintain their ... essential part of any reputable treatment programme. As a ...
(Date:7/14/2014)... new analysis has found that rates of testicular cancer ... Hispanic American men, but not among their non-Hispanic counterparts. ... journal of the American Cancer Society, the findings indicate ... of testicular cancer in Hispanic adolescents and young adults, ... cause of this trend. , Testicular cancer is one ...
Breaking Medicine News(10 mins):Health News:Dry Eye Handbook Review | Taking Care of One’s Vision by Using Natural Methods – Vinamy.com 2Health News:Dry Eye Handbook Review | Taking Care of One’s Vision by Using Natural Methods – Vinamy.com 3Health News:Passionate Playground launches Joyboxx 2Health News:Passionate Playground launches Joyboxx 3Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 2Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 3Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 4Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 5Health News:Harris Publications and Danny Seo Launch NATURALLY, DANNY SEO Magazine 6Health News:The Cabin Chiang Mai Addiction Rehab Launches Industry-leading Aftercare Service 2Health News:The Cabin Chiang Mai Addiction Rehab Launches Industry-leading Aftercare Service 3Health News:Testicular cancer rates are on the rise in young Hispanic Americans 2
... ... ... ... ...
... For some Canadians, any cut such as from dental work ... they are not hemophiliacs, for some an ordinary bruise can ... elbows and ankles are crippled when bleeding seeps into joints. ... for recovery. Now a team led by McMaster ...
... with communications and recovery for people with disabilities following ... a research paper in the International Journal of ... Katrina and Rita, other natural disasters, and even technological ... serious need for disaster and emergency preparedness for people ...
... of Contemporary Spirituality will take place at the University of ... an astounding 32 sessions and dozens of lectures presenting studies ... around the world. "This is a wide phenomenon that touches ... the academic world and its various disciplines have found it ...
... ... ... Maryland Gov. Martin O’Malley proposes cutting $123 million from Medicaid for the 2011 budget, in ... Todd Eberly, assistant professor of political science and coordinator of public policy studies at ...
... with aura, researchers say , THURSDAY, March 4 (HealthDay News) ... the head may offer relief for some migraine sufferers, researchers ... experience "aura," expand on previous research by using a device ... doctor,s office. , It,s unclear, however, how expensive the treatment ...
Cached Medicine News:Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 2Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 3Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 4Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 5Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 6Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 7Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 8Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 9Health News:Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update 10Health News:Genetic cause discovered for rare bleeding disorder 2Health News:Emergency online communities 2Health News:Proposed Medicaid Cuts Threatens Health Care Access for 400,000 Maryland Children 2Health News:Proposed Medicaid Cuts Threatens Health Care Access for 400,000 Maryland Children 3Health News:New Hope for Migraine Patients 2
45 degree. Angled shafts. Tip to angle length: 11.5 mm. Stops in handle designed to prevent "over folding". Manufactured in titanium....
30 degree angled tip with 45 mm tip opening. Stainless....
Straight 25 gauge shaft with angled tip and sliding inner shaft. Shaft holds the proximal loop against the angled tip while handle in the normal state. Squeeze type handle with dull finish....
... Curvilinear design and reduced ... Offers excellent control of IOL ... periphery of the optic. Curved ... tips gently curved. Smooth, flat, ...
Medicine Products: