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Sunesis Pharmaceuticals Announces Presentation of Voreloxin Clinical Data in Patients with Acute Myeloid Leukemia at the 50th Annual Meeting of the American Society of Hematology
Date:12/7/2008

s occurring in more than 10 percent of patients include febrile neutropenia, mucosal inflammation and infections. The 30-day all-cause mortality rate was 17 percent, which compares favorably to standard induction chemotherapy. Infection was the most common cause of early mortality.

Pre-specified complete remission criteria were exceeded in Schedule A. In an effort to improve tolerability while maintaining anti-leukemic activity, an alternative dose regimen is being investigated. Twenty-one patients have been enrolled and treated with 72 mg/m(2) of voreloxin dosed weekly for two weeks (Schedule B). Early data from these patients suggest that Schedule B appears to be better tolerated and anti-leukemic activity has been maintained. To date, of 18 evaluable patients, one achieved a CRp and five are hypoplastic and are awaiting hematologic count recovery. Three additional patients with bone marrow blast reductions are undergoing second induction cycles of treatment. Patients on Schedule B have demonstrated improved tolerability. The 30-day all-cause mortality is currently 6 percent.

"We have made great strides this year in our voreloxin program," said Daniel Swisher, Chief Executive Officer of Sunesis. "In just over six months, more than 50 patients have been enrolled in the REVEAL-1 Phase 2 trial. We believe this underscores the enthusiasm of the clinical investigators for voreloxin and the high unmet medical need for elderly AML patients."

"Voreloxin's anti-leukemic activity in this previously untreated, older adult patient population with AML is promising," said Robert K. Stuart, M.D., Professor of Medicine, Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, and an investigator in the study. "I am encouraged by the complete remissions observed thus far in patients who are unlikely to benefit from standard induction therapy."

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SOURCE Sunesis Pharmaceuticals, Inc.
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